{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T17:00:47Z","timestamp":1788886847895,"version":"build-2803163510"},"reference-count":77,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec026\">\n<jats:title>Background<\/jats:title>\n<jats:p>Bread, a staple food, is at risk of contamination from heavy metals that pose significant health hazards. This study aimed to assess the levels of heavy metals, including Cu, Zn, Fe, Al, Co, As, Hg, Cr, Ni, Pb, Cd, and V, in bread samples collected from bakeries in Mashhad, Iran, and to evaluate the associated health and carcinogenic risks.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec027\">\n<jats:title>Methods<\/jats:title>\n<jats:p>In this study, the urban area was divided into five regions using simple random sampling. A total of 270 samples, including flour, dough, and bread, were collected from bakeries between June and December 2020. After preparing the samples and applying an acid digestion method, the concentration of heavy metals were determined using an inductively coupled plasma optical emission spectrometer.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec028\">\n<jats:title>Results<\/jats:title>\n<jats:p>Levels of Al, As, Cr, and Fe exceeded WHO and FAO thresholds in all regions. The health risk assessment indicated that non-carcinogenic risks from arsenic and the mean hazard index for bread consumption exceeded 1 in both adults and children, suggesting potential health risks. Moreover, carcinogenic risk indices for both age groups surpassed the acceptable limit (CR\u2009&gt;\u20091\u2009\u00d7\u200910<jats:sup>\u22124<\/jats:sup>) across all regions, indicating potential carcinogenic effects.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec029\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The findings reveal significant health and carcinogenic risks linked to bread consumption in Mashhad. Continuous monitoring of heavy metal levels in wheat and related food products is recommended to protect public health.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0327652","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T17:36:41Z","timestamp":1753292201000},"page":"e0327652","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Human health risk assessment of arsenic and potentially toxic elements exposure in bread and wheat flour in Northeast Iran"],"prefix":"10.1371","volume":"20","author":[{"given":"Fateme","family":"Asadi Touranlou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajjad","family":"Ghasemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Gholian 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Cotruvo","year":"1988","journal-title":"Regul Toxicol Pharmacol"},{"issue":"1","key":"pone.0327652.ref006","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12199-019-0812-x","article-title":"Health risk assessments of arsenic and toxic heavy metal exposure in drinking water in northeast Iran","volume":"24","author":"H Alidadi","year":"2019","journal-title":"Environ Health Prev Med"},{"issue":"4","key":"pone.0327652.ref007","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1111\/1541-4337.12559","article-title":"Occurrence, sources, and pathways of chemical contaminants in infant formulas","volume":"19","author":"BF de Mendon\u00e7a Pereira","year":"2020","journal-title":"Compr Rev Food Sci Food Saf"},{"key":"pone.0327652.ref008","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jhazmat.2011.07.058","article-title":"Heavy metal and trace element concentrations in wheat grains: assessment of potential non-carcinogenic health hazard through their 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W","year":"1995"},{"key":"pone.0327652.ref022","doi-asserted-by":"crossref","first-page":"198","DOI":"10.6000\/1927-5129.2017.13.34","article-title":"Determination of heavy metals in the different samples of table salt","volume":"13","author":"R Muhammad","year":"2017","journal-title":"J Basic Appl Sci"},{"issue":"7","key":"pone.0327652.ref023","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.fct.2007.01.007","article-title":"Arsenic in seaweed--forms, concentration and dietary exposure","volume":"45","author":"M Rose","year":"2007","journal-title":"Food Chem Toxicol"},{"key":"pone.0327652.ref024","doi-asserted-by":"crossref","first-page":"8458057","DOI":"10.1155\/2017\/8458057","article-title":"Safety evaluation of potential toxic metals exposure from street foods consumed in mid-west Nigeria","volume":"2017","author":"OC Ekhator","year":"2017","journal-title":"J Environ Public 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Hashemi","year":"2019","journal-title":"Biol Trace Elem Res"},{"issue":"1","key":"pone.0327652.ref031","article-title":"Effect of baking methods types on residues of heavy metals in the different breads produced with wheat flour in Iran: a case study of Mashhad","volume":"12","author":"S Ghasemi","year":"2022","journal-title":"J Chem Health Risks"},{"key":"pone.0327652.ref032","first-page":"1","article-title":"Health risk assessment of exposure to heavy metals in wheat flour from Iran markets: application of Monte Carlo simulation approach","author":"F Asadi Touranlou","year":"2024","journal-title":"Biol Trace Element Res"},{"key":"pone.0327652.ref033","volume-title":"Method 3050B acid digestion of sediments, sludges, and soils 1.0 scope and application","author":"AM Arsenic","year":"1996"},{"issue":"56","key":"pone.0327652.ref034","doi-asserted-by":"crossref","first-page":"32839","DOI":"10.1039\/C9RA05587H","article-title":"A rapid on-site analysis method for the simultaneous extraction and determination of Pb2+ and Cd2+ in cereals","volume":"9","author":"M-H Zhou","year":"2019","journal-title":"RSC Adv"},{"key":"pone.0327652.ref035","volume-title":"Risk assessment guidance for superfund. Volume I: human health evaluation manual (Part E, supplemental guidance for dermal risk assessment). 540\/R\/99","author":"EPA A","year":"2004"},{"key":"pone.0327652.ref036","volume-title":"Dermal exposure assessment: a summary of EPA approaches","author":"Epa U","year":"2007"},{"key":"pone.0327652.ref037","volume-title":"Exposure factors handbook 2011 edition (final)","author":"EPA U","year":"2011"},{"key":"pone.0327652.ref038","volume-title":"Basic information about the integrated risk information system","author":"EPA U","year":"2018"},{"key":"pone.0327652.ref039","volume-title":"Integrated Risk Information System. Bisphenol A","author":"USEPA","year":"2016"},{"key":"pone.0327652.ref040","author":"EPA U. Guidelines for carcinogen risk assessment","year":"2005"},{"issue":"4","key":"pone.0327652.ref041","doi-asserted-by":"crossref","DOI":"10.17795\/jhealthscope-18175","article-title":"A Comparative evaluation of heavy metals in the different breads in Iran: a case study of rasht city","volume":"3","author":"D Naghipour","year":"2014","journal-title":"Health Scope"},{"key":"pone.0327652.ref042","author":"EPA U. Exposure factors handbook 2011 edition (final report)","year":"2011"},{"issue":"31","key":"pone.0327652.ref043","doi-asserted-by":"crossref","first-page":"30928","DOI":"10.1007\/s11356-018-3030-y","article-title":"The concentration of heavy metals in noodle samples from Iran\u2019s market: probabilistic health risk assessment","volume":"25","author":"B Tajdar-Oranj","year":"2018","journal-title":"Environ Sci Pollut Res Int"},{"issue":"17","key":"pone.0327652.ref044","doi-asserted-by":"crossref","first-page":"25892","DOI":"10.1007\/s11356-024-32795-z","article-title":"Health risk assessments of heavy metals and trace elements exposure in the breast milk of lactating mothers in the Northeastern Iran","volume":"31","author":"S Rahati","year":"2024","journal-title":"Environ Sci Pollut Res Int"},{"issue":"1","key":"pone.0327652.ref045","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s10653-020-00675-3","article-title":"Health risk and temporal trend of dietary potentially toxic elements exposure in the residents of the Shenzhen metropolis, China, between 2005 and 2017: a risk assessment based on probabilistic estimation","volume":"43","author":"Y Wang","year":"2021","journal-title":"Environ Geochem Health"},{"issue":"9","key":"pone.0327652.ref046","doi-asserted-by":"crossref","first-page":"4334","DOI":"10.1007\/s12011-022-03538-3","article-title":"Deterministic and probabilistic health risk assessment of toxic metals in the daily diets of residents in industrial regions of Northern Ningxia, China","volume":"201","author":"Y Wang","year":"2023","journal-title":"Biol Trace Elem Res"},{"key":"pone.0327652.ref047","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.foodchem.2018.10.090","article-title":"Human health risk assessment for some toxic metals in widely consumed rice brands (domestic and imported) in Tehran, Iran: uncertainty and sensitivity analysis","volume":"277","author":"K Sharafi","year":"2019","journal-title":"Food Chem"},{"key":"pone.0327652.ref048","first-page":"1","article-title":"Potentially toxic element (PTE) levels in maize, soil, and irrigation water and health risks through maize consumption in northern Ningxia, China","volume":"20","author":"P Liu","year":"2020","journal-title":"BMC Public Health"},{"issue":"10","key":"pone.0327652.ref049","first-page":"88","article-title":"The levels of trace metals contaminants in wheat grains, flours and breads in Iraq","volume":"6","author":"I Jawad","year":"2012","journal-title":"Aust J Basic Appl Sci"},{"key":"pone.0327652.ref050","unstructured":"Shiralipour R, Jahangiri A, Baaghdezfooli M. Determination of iron, zinc and copper in fortified wheat flour consumed in Ahvaz. 2017."},{"issue":"2","key":"pone.0327652.ref051","doi-asserted-by":"crossref","first-page":"17","DOI":"10.11648\/j.ajac.20130102.11","article-title":"Levels of selected heavy metals in wheat flour on the ghanaian market: a determination by atomic absorption spectrometry","volume":"1","author":"ED Doe","year":"2013","journal-title":"Am J Appl Chem"},{"issue":"3","key":"pone.0327652.ref052","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0089715","article-title":"Dietary exposure to aluminium and health risk assessment in the residents of Shenzhen, China","volume":"9","author":"M Yang","year":"2014","journal-title":"PLoS One"},{"key":"pone.0327652.ref053","first-page":"1","article-title":"Safety of aluminium from dietary intake scientific opinion of the panel on food additives, flavourings, processing aids and food contact materials (AFC)","volume":"754","author":"F Aguilar","year":"2008","journal-title":"EFSA J"},{"key":"pone.0327652.ref054","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.foodchem.2018.10.069","article-title":"A review of arsenic in crops, vegetables, animals and food products","volume":"276","author":"MK Upadhyay","year":"2019","journal-title":"Food Chem"},{"issue":"311","key":"pone.0327652.ref055","first-page":"67","article-title":"Health assessment of arsenic and zinc in rice cultivated in Fars Province (case study: Firoozabad Fields)","volume":"3","author":"M Cheraghi","year":"2013","journal-title":"Food Hyg"},{"key":"pone.0327652.ref056","unstructured":"Tourchi M, Seyedain AS, Azizinezhad R, Nematollahi F. Assessing the Effect of Baking Methods on the Levels of Heavy Metals in Iranian Traditional Breads. 2017."},{"key":"pone.0327652.ref057","doi-asserted-by":"crossref","unstructured":"Arabamirabadi A, Moogui R, Sadjadi N, Jozi S, Ramezani M. Investigating the amount of toxic metals (arsenic, cadmium and lead) in wheat and wheat flour in Golestan and Mazandaran provinces. 2020.","DOI":"10.52547\/fsct.17.101.131"},{"issue":"4","key":"pone.0327652.ref058","first-page":"301","article-title":"Trace metal contaminants in Iranian flat breads","volume":"1","author":"GRJ Khaniki","year":"2005","journal-title":"J Agric Soc Sci"},{"issue":"4","key":"pone.0327652.ref059","first-page":"36","article-title":"A survey on lead and cadmium content in bread produced in yazd","volume":"14","author":"B Hajimohammadi","year":"2015","journal-title":"Tolooebehdasht"},{"issue":"4","key":"pone.0327652.ref060","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1080\/10807039.2018.1456898","article-title":"Cadmium and lead in rice grains and wheat breads in Isfahan (Iran) and human health risk assessment","volume":"25","author":"F Ghoreishy","year":"2018","journal-title":"Hum Ecol Risk Assess: An Int J"},{"issue":"5","key":"pone.0327652.ref061","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3923\/pjn.2009.585.587","article-title":"A Comparative evaluation of heavy metals in commercial wheat flours sold in Calabar-Nigeria","volume":"8","author":"E Christophe","year":"2009","journal-title":"Pak J Nutr"},{"issue":"1","key":"pone.0327652.ref062","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.2903\/j.efsa.2012.2551","article-title":"Cadmium dietary exposure in the European population","volume":"10","year":"2012","journal-title":"EFSA J"},{"issue":"85","key":"pone.0327652.ref063","first-page":"29","article-title":"Contamination of cereal products with lead and cadmium as a factor of a health risk for people in Podlaskie Voivodship","volume":"63","author":"J Fi\u0142on","year":"2013","journal-title":"Vet Med Zoot"},{"key":"pone.0327652.ref064","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.toxrep.2014.05.007","article-title":"Bromate and trace metal levels in bread loaves from outlets within Ile-Ife Metropolis, Southwestern Nigeria","volume":"1","author":"JAO Oyekunle","year":"2014","journal-title":"Toxicol Rep"},{"issue":"10","key":"pone.0327652.ref065","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s10661-015-4884-9","article-title":"Human health risk assessment of heavy metals in the irrigated area of Jinghui, Shaanxi, China, in terms of wheat flour consumption","volume":"187","author":"L Lei","year":"2015","journal-title":"Environ Monit Assess"},{"issue":"2","key":"pone.0327652.ref066","first-page":"232","article-title":"Potassium bromate and heavy metal content of selected bread samples produced in Zaria, Nigeria","volume":"2","author":"A Magomya","year":"2013","journal-title":"Int J Sci Technol"},{"issue":"2","key":"pone.0327652.ref067","doi-asserted-by":"crossref","first-page":"77","DOI":"10.29252\/jfqhc.5.2.8","article-title":"Quality assessment of wheat bread baked in Bahir Dar City, Ethiopia","volume":"5","author":"M Eshetu","year":"2018","journal-title":"J Food Qual Hazards Control"},{"issue":"2","key":"pone.0327652.ref068","first-page":"506","article-title":"Metals in wheat flour; comparative study and safety control","volume":"28","author":"RL Tejera","year":"2013","journal-title":"Nutr Hosp"},{"issue":"2","key":"pone.0327652.ref069","doi-asserted-by":"crossref","DOI":"10.1007\/s12517-018-4190-2","article-title":"The influence of soil pollution by heavy metals on the land suitability for irrigated wheat farming in Zanjan region, northwest Iran","volume":"12","author":"Y Safari","year":"2019","journal-title":"Arab J Geosci"},{"issue":"4","key":"pone.0327652.ref070","first-page":"2093","article-title":"potential health risk assessment of different heavy metals in wheat products","volume":"18","author":"K Ghanati","year":"2019","journal-title":"Iran J Pharm Res"},{"issue":"4","key":"pone.0327652.ref071","article-title":"Measurement of the toxic trace elements in commercial wheat flours: potential health risk via dietary intake","volume":"12","author":"SMA Noori","year":"2022","journal-title":"J Chem Health Risks"},{"key":"pone.0327652.ref072","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.toxrep.2023.02.015","article-title":"Determination of metal(oids) in different traditional flat breads distributed in Isfahan city, Iran: Health risk assessment study by latin hypercube sampling","volume":"10","author":"SM Khodaei","year":"2023","journal-title":"Toxicol Rep"},{"key":"pone.0327652.ref073","doi-asserted-by":"crossref","DOI":"10.1017\/jns.2022.70","article-title":"Levels of selected essential and non-essential metals in wheat (Triticum aestivum) flour in Ethiopia","volume":"11","author":"WD Alemu","year":"2022","journal-title":"J Nutr Sci"},{"issue":"3","key":"pone.0327652.ref074","first-page":"269","article-title":"Health risk assessment and dietary exposure of polycyclic aromatic hydrocarbons (PAHs), lead and cadmium from bread consumed in Nigeria","volume":"68","author":"NA Udowelle","year":"2017","journal-title":"Rocz Panstw Zakl Hig"},{"key":"pone.0327652.ref075","doi-asserted-by":"crossref","first-page":"219840","DOI":"10.1155\/2013\/219840","article-title":"Chelation: harnessing and enhancing heavy metal detoxification--a review","volume":"2013","author":"ME Sears","year":"2013","journal-title":"ScientificWorldJournal"},{"issue":"19","key":"pone.0327652.ref076","doi-asserted-by":"crossref","first-page":"8085","DOI":"10.1080\/03067319.2023.2192872","article-title":"Investigation of heavy metal release from variety cookware into food during cooking process","volume":"104","author":"E Shamloo","year":"2024","journal-title":"Int J Environ Anal Chem"},{"issue":"1","key":"pone.0327652.ref077","doi-asserted-by":"crossref","first-page":"49","DOI":"10.17350\/HJSE19030000290","article-title":"Monitoring of lead and some heavy metals in wheat flour of Corum Province, Turkey: an air quality comparison","volume":"10","author":"E \u00d6lmez","year":"2023","journal-title":"Hittite J Sci Eng"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0327652","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T17:36:53Z","timestamp":1753292213000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0327652"}},"subtitle":[],"editor":[{"given":"Karthikeyan","family":"Venkatachalam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,7,23]]},"references-count":77,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0327652","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,23]]}}}