{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:41:48Z","timestamp":1755225708791,"version":"3.43.0"},"reference-count":78,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Institut National du Cancer","award":["SPAV1-23-009-2023-209"],"award-info":[{"award-number":["SPAV1-23-009-2023-209"]}]},{"name":"Belgian Fund for Scientific Research"},{"DOI":"10.13039\/501100020049","name":"Brugmann Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec012\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>This exploratory study investigates approach\/avoidance tendencies in male patients with Alcohol Use Disorder (AUD) through a gait initiation task combined with posturography.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec013\">\n<jats:title>Method<\/jats:title>\n<jats:p>Seventy-four male participants (N\u2009=\u200974), including 47 AUD patients undergoing detoxification and 27 healthy controls, were exposed to alcohol-related, erotic, and neutral visual stimuli. Reaction times (RTs) and postural micromovements preceding gait initiation (forward\/backward steps) were recorded to assess their predictive value for relapse (n\u2009=\u200913) or abstinence (n\u2009=\u200934) within two weeks post-detoxification.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec014\">\n<jats:title>Results<\/jats:title>\n<jats:p>A mixed ANOVA (2x2x3) revealed significant group differences in RTs to alcohol-related stimuli (Stimuli\u2009\u00d7\u2009Group interaction: p\u2009=\u2009.029), with relapsers showing slower responses to alcohol cues than abstainers for forward as well as backward steps. Additionally, postural micromovements before gait initiation (measured through the standard deviation of the center of pressure\u2019s position) showed a significant Stimuli\u2009\u00d7\u2009Group interaction (p\u2009=\u20090.05), with relapsers displaying increased micromovements when exposed to alcohol-related stimuli (p\u2009=\u2009.044).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec015\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>These findings suggest that relapsers exhibited distinct motor responses to alcohol-related stimuli, characterized by delayed RTs and increased postural instability. These early indicators of relapse risk highlight the potential of posturography as a clinical tool in alcohol detoxification programs.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0327765","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T17:21:24Z","timestamp":1755105684000},"page":"e0327765","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigating approach\/avoidance tendencies in male AUD patients through a gait initiation task: An exploratory posturography study"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7331-5906","authenticated-orcid":true,"given":"Salvatore","family":"Campanella","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6393-7739","authenticated-orcid":true,"given":"Macha","family":"Dubuson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maylis","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3425-3255","authenticated-orcid":true,"given":"Harold","family":"Mouras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Leonard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Noel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Lelard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"issue":"50","key":"pone.0327765.ref001","article-title":"Association between alcoholic interventions and abstinence rates for alcohol use disorders: A meta-analysis","volume":"97","author":"J Gao","year":"2018","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"pone.0327765.ref002","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13033-022-00527-w","article-title":"HIV related stigma associated with social support, alcohol use disorders, depression, anxiety, and suicidal ideation among people living with HIV: a systematic review and meta-analysis","volume":"16","author":"B Armoon","year":"2022","journal-title":"Int J Ment Health Syst"},{"issue":"17","key":"pone.0327765.ref003","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1001\/jama.2023.19761","article-title":"Pharmacotherapy for alcohol use disorder: a systematic review and meta-analysis","volume":"330","author":"M McPheeters","year":"2023","journal-title":"JAMA"},{"key":"pone.0327765.ref004","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s11920-011-0224-0","article-title":"New findings on biological factors predicting addiction relapse vulnerability","volume":"13","author":"R Sinha","year":"2011","journal-title":"Current psychiatry reports"},{"key":"pone.0327765.ref005","doi-asserted-by":"crossref","first-page":"877","DOI":"10.3389\/fpsyt.2019.00877","article-title":"A roadmap for integrating neuroscience into addiction treatment: a consensus of the neuroscience interest group of the international society of addiction medicine","volume":"10","author":"A Verdejo-Garcia","year":"2019","journal-title":"Front Psychiatry"},{"key":"pone.0327765.ref006","doi-asserted-by":"crossref","first-page":"107128","DOI":"10.1016\/j.addbeh.2021.107128","article-title":"Modeling alcohol use disorder as a set of interconnected symptoms - Assessing differences between clinical and population samples and across external factors","volume":"125","author":"KBS Huth","year":"2022","journal-title":"Addict Behav"},{"issue":"2","key":"pone.0327765.ref007","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1530-0277.2011.01620.x","article-title":"To approach or avoid alcohol? 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