{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T13:03:38Z","timestamp":1770987818446,"version":"3.50.1"},"reference-count":79,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26750307"],"award-info":[{"award-number":["26750307"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K10637"],"award-info":[{"award-number":["23K10637"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Grant from Advanced Research Initiative for Human High Performance (ARIHHP), University of Tsukuba."}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>Acute moderate-intensity exercise (AME) after learning has been reported to exogenously boost consolidation of hippocampus-dependent memory, resulting in improved long-term persistence. However, the neuronal mechanism remains poorly understood. Short-term, hippocampus-dependent memory produced by weak encoding can be transformed into long-term memory through an immediate, strong behavioral event, which causes overlapping activation of the hippocampus. Hippocampal <jats:italic>de novo<\/jats:italic> protein synthesis is essential for achieving memory consolidation in this way. As AME activates the hippocampus, enhanced memory consolidation through post-learning AME may also be mediated by protein synthesis in the hippocampus. To test this hypothesis, this study first attempted to establish a rat model for enhancing memory consolidation via post-learning AME with the object location (OL) test, a hippocampus-dependent spatial memory task. This study used adult male Sprague-Dawley rats, and the AME load was based on the running speed corresponding to the rats\u2019 lactate threshold (20 m\/min) for 20\u2009min. We then examined the effects of the protein synthesis inhibitor anisomycin (ANI), injected into the dorsal hippocampus, on AME-induced OL memory consolidation. In the OL test, the OL memory encoded with 5\u2009min of learning was retained for at least 1\u2009hr but was lost after 24\u2009hr. With a single bout of AME immediately after the 5\u2009min of OL learning, the memory persisted for 24\u2009hr, indicating AME-induced memory consolidation. The AME-induced OL memory consolidation did not occur when ANI was injected into the dorsal hippocampus immediately or 4\u2009hr after OL learning. These findings support the hypothesis that post-learning AME-induced memory consolidation depends on new-protein synthesis in the dorsal hippocampus and highlight the value of AME after learning as a strategy for enhancing memory consolidation. This is a potential base model for future research examining the mechanism behind boosting memory consolidation with exercise.<\/jats:p>","DOI":"10.1371\/journal.pone.0328128","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T17:24:11Z","timestamp":1752859451000},"page":"e0328128","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Memory persistence enhancement by post-learning moderate exercise requires de novo protein synthesis in the dorsal 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