{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T03:47:14Z","timestamp":1781754434730,"version":"3.54.5"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["JP19K17758"],"award-info":[{"award-number":["JP19K17758"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004017","name":"Japanese Association of Dialysis Physicians","doi-asserted-by":"publisher","award":["JADP grant number 2023-1"],"award-info":[{"award-number":["JADP grant number 2023-1"]}],"id":[{"id":"10.13039\/501100004017","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Grant-in-Aid for Progressive Renal Disease Research from the Ministry of Health, Labour, and Welfare of Japan"},{"DOI":"10.13039\/100012832","name":"Okinaka Memorial Institute for Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012832","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease and Polycystic liver disease (PLD) is the most common extrarenal manifestation of ADPKD. Various non-inherited factors have been reported to affect total kidney volume (TKV) in ADPKD. However, the non-inherited factors affecting liver volume (LV) in ADPKD are unknown.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>We aimed to identify the factors affecting LV and TKV in ADPKD; and to analyze the relationship between changes in these parameters and arterial stiffness, assessed using brachial-ankle pulse wave velocity (baPWV).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>We enrolled 165 patients (66 men and 99 women; mean age 47.3\u2009\u00b1\u20096.9 years). Univariable analysis revealed that sex, mean baPWV, \u0394baPWV, tolvaptan use, hyperlipidemia, hyperuricemia, Hb concentration, eGFR, proteinuria, and height-adjusted TKV (htTKV) were significantly associated with height-adjusted LV (htLV) at baseline. Multivariate analysis showed that sex, BMI, \u0394baPWV, and tolvaptan use were significantly associated with htLV at baseline. The baseline htLV correlated with \u0394baPWV (<jats:italic>r<\/jats:italic>\u2009=\u20090.32, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Univariable linear mixed model analysis revealed that sex, mean baPWV, \u0394baPWV, tolvaptan use, hyperuricemia, Hb concentration, eGFR, and proteinuria significantly affected the change in htLV. Multivariate linear mixed model analysis revealed that sex, BMI, and tolvaptan use significantly affected the change in htLV. The change in the htLV ratio was larger in patients with a higher \u0394baPWV (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Whereas, \u0394baPWV was not a significant factor for the baseline htTKV and the changes in htTKV in univariable and multivariable analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>We have shown that \u0394baPWV is a predictor of baseline htLV, and the chronological changes in htLV in patients with ADPKD.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0328133","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T17:38:41Z","timestamp":1753119521000},"page":"e0328133","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Brachial-ankle pulse wave velocity predicts liver volume in patients with autosomal dominant polycystic kidney 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