{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T02:57:37Z","timestamp":1783133857598,"version":"3.54.6"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Purpose<\/jats:title>\n<jats:p>To characterize patients with choroidal or ciliary body (CB) melanoma in order to identify factors associated with time until metastasis and further perform a detailed characterization of the factors identified.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>A mixed model approach was used to identify parameters and patient characteristics associated with time until metastatic event. Consequently, the identified parameters were characterized.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>In 383 patients with primary choroidal and CB melanoma, tumor thickness and patient age at diagnosis are associated with time until metastatic event. Mean patient age was 61\u2009\u00b1\u200913 years, mean choroidal and CB melanoma thickness was 5.1\u2009\u00b1\u20091.9 mm. Other factors investigated comprising sex, primary tumor width, length, volume, shape, and type of therapy are not associated with time until metastatic event in this patient collective.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>In conclusion, this study expands the current knowledge on factors associated with metastasis due to primary choroidal or CB melanoma. So far primary choroidal or CB melanoma thickness has been shown to be a risk indicator for metastatic events. Now, we could show that primary choroidal or CB melanoma thickness is also correlated with time until metastatic event. The association can be expressed as: the thicker the primary tumor, the earlier the potential metastatic event. Age may be considered an indirect effect in the model calculated.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0328360","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T17:21:31Z","timestamp":1755624091000},"page":"e0328360","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Factors associated with time until metastatic spread in patients with primary uveal melanoma: A retrospective analysis"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2046-7081","authenticated-orcid":true,"given":"Reinhard","family":"Told","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Reumueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1548-3629","authenticated-orcid":true,"given":"Judith","family":"Kreminger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Sacu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Dunavoelgyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"issue":"1","key":"pone.0328360.ref001","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ohc.2004.09.001","article-title":"Management of advanced retinoblastoma","volume":"18","author":"SG Honavar","year":"2005","journal-title":"Ophthalmol Clin North Am"},{"issue":"5","key":"pone.0328360.ref002","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.ctrv.2012.01.002","article-title":"Uveal melanoma","volume":"38","author":"F Spagnolo","year":"2012","journal-title":"Cancer Treat Rev"},{"issue":"4","key":"pone.0328360.ref003","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1586\/14737140.6.4.493","article-title":"Treatment of primary intraocular melanoma","volume":"6","author":"B Damato","year":"2006","journal-title":"Expert Rev Anticancer Ther"},{"issue":"7","key":"pone.0328360.ref004","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1097\/IAE.0b013e31824d09a8","article-title":"Clinical spectrum and prognosis of uveal melanoma based on age at presentation in 8,033 cases","volume":"32","author":"CL Shields","year":"2012","journal-title":"Retina"},{"issue":"8","key":"pone.0328360.ref005","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1001\/archophthalmol.2009.208","article-title":"Metastasis of uveal melanoma millimeter-by-millimeter in 8033 consecutive eyes","volume":"127","author":"CL Shields","year":"2009","journal-title":"Arch Ophthalmol"},{"issue":"2","key":"pone.0328360.ref006","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1001\/archopht.1992.01080140101036","article-title":"A review of mortality from choroidal melanoma. 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A meta-analysis of 5-year mortality rates following enucleation, 1966 through 1988","volume":"110","author":"M Diener-West","year":"1992","journal-title":"Arch Ophthalmol"},{"issue":"7","key":"pone.0328360.ref007","first-page":"1230","article-title":"Ocular melanoma: an overview of the current status","volume":"6","author":"P Jovanovic","year":"2013","journal-title":"Int J Clin Exp Pathol"},{"issue":"8","key":"pone.0328360.ref008","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/eye.2015.51","article-title":"Prognosis of uveal melanoma based on race in 8100 patients: The 2015 Doyne Lecture","volume":"29","author":"CL Shields","year":"2015","journal-title":"Eye (Lond)"},{"issue":"4","key":"pone.0328360.ref009","first-page":"612","article-title":"Population-based incidence of uveal melanoma in various races and ethnic groups","volume":"140","author":"D-N Hu","year":"2005","journal-title":"Am J Ophthalmol"},{"issue":"8","key":"pone.0328360.ref010","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1080\/02713683.2017.1297997","article-title":"Uveal melanoma risk factors: a systematic review of meta-analyses","volume":"42","author":"T Nayman","year":"2017","journal-title":"Curr Eye Res"},{"issue":"1","key":"pone.0328360.ref011","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1001\/archopht.124.1.54","article-title":"The association between host susceptibility factors and uveal melanoma: a meta-analysis","volume":"124","author":"E Weis","year":"2006","journal-title":"Arch Ophthalmol"},{"issue":"9","key":"pone.0328360.ref012","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1001\/archopht.1990.01070110084030","article-title":"Accuracy of diagnosis of choroidal melanomas in the Collaborative Ocular Melanoma Study. 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Kujala","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"pone.0328360.ref019","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1016\/j.ophtha.2008.01.032","article-title":"Artificial neural networks estimating survival probability after treatment of choroidal melanoma","volume":"115","author":"B Damato","year":"2008","journal-title":"Ophthalmology"},{"issue":"3","key":"pone.0328360.ref020","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1136\/bjo-2022-322750","article-title":"Impact of tumour volume and treatment delay on the outcome after linear accelerator-based fractionated stereotactic radiosurgery of uveal melanoma","volume":"108","author":"S Sreenivasa","year":"2024","journal-title":"Br J Ophthalmol"},{"issue":"12","key":"pone.0328360.ref021","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1001\/jamaophthalmol.2018.3881","article-title":"Visual outcome and millimeter incremental risk of metastasis in 1780 patients with small choroidal melanoma managed by plaque radiotherapy","volume":"136","author":"CL Shields","year":"2018","journal-title":"JAMA Ophthalmol"},{"issue":"6","key":"pone.0328360.ref022","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.3892\/ijo.2020.5140","article-title":"Update on uveal melanoma: translational research from biology to clinical practice (Review)","volume":"57","author":"MA Ortega","year":"2020","journal-title":"Int J Oncol"},{"key":"pone.0328360.ref023","doi-asserted-by":"crossref","first-page":"100800","DOI":"10.1016\/j.preteyeres.2019.100800","article-title":"Uveal melanoma: towards a molecular understanding","volume":"75","author":"KN Smit","year":"2020","journal-title":"Prog Retin Eye Res"},{"issue":"8","key":"pone.0328360.ref024","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1101\/gad.296962.117","article-title":"Focus on cutaneous and uveal melanoma specificities","volume":"31","author":"C Pandiani","year":"2017","journal-title":"Genes Dev"},{"issue":"5","key":"pone.0328360.ref025","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/ceo.14214","article-title":"Current management of uveal melanoma: a review","volume":"51","author":"H Bai","year":"2023","journal-title":"Clin Exp Ophthalmol"},{"issue":"3","key":"pone.0328360.ref026","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/CMR.0000000000000519","article-title":"20-year assessment of metastatic latency and subsequent time to death after proton therapy for uveal melanomas","volume":"30","author":"D Bellocq","year":"2020","journal-title":"Melanoma Res"},{"issue":"7","key":"pone.0328360.ref027","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1001\/archopht.1985.01050070050028","article-title":"Comparison of uveal melanoma growth rates with mitotic index and mortality","volume":"103","author":"JD Gass","year":"1985","journal-title":"Arch Ophthalmol"},{"issue":"1","key":"pone.0328360.ref028","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ijrobp.2010.04.035","article-title":"Local tumor control, visual acuity, and survival after hypofractionated stereotactic photon radiotherapy of choroidal melanoma in 212 patients treated between 1997 and 2007","volume":"81","author":"R Dunavoelgyi","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"pone.0328360.ref029","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0167-8140(01)00413-3","article-title":"A linac-based stereotactic irradiation technique of uveal melanoma","volume":"61","author":"K Dieckmann","year":"2001","journal-title":"Radiother Oncol"},{"issue":"12","key":"pone.0328360.ref030","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1118\/1.1824195","article-title":"Automatic real-time surveillance of eye position and gating for stereotactic radiotherapy of uveal melanoma","volume":"31","author":"B Petersch","year":"2004","journal-title":"Med Phys"},{"key":"pone.0328360.ref031","unstructured":"Hyrcza M. Staging-uvea melanoma PathologyOutlines.com. 2024. [cited 2024 May 15]. Available from: https:\/\/www.pathologyoutlines.com\/topic\/eyeuveatnmuvealmelanoma.html"},{"issue":"3","key":"pone.0328360.ref032","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/ICU.0000000000000041","article-title":"Choroidal melanoma: clinical features, classification, and top 10 pseudomelanomas","volume":"25","author":"CL Shields","year":"2014","journal-title":"Curr Opin Ophthalmol"},{"issue":"6","key":"pone.0328360.ref033","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1136\/bjo.62.6.420","article-title":"Does enucleation of the eye containing a malignant melanoma prevent or accelerate the dissemination of tumour cells","volume":"62","author":"LE Zimmerman","year":"1978","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"pone.0328360.ref034","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41572-020-0158-0","article-title":"Uveal melanoma","volume":"6","author":"MJ Jager","year":"2020","journal-title":"Nat Rev Dis Primers"},{"issue":"4","key":"pone.0328360.ref035","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.ophtha.2023.10.026","article-title":"Improved staging of ciliary body and choroidal melanomas based on estimation of tumor volume and competing risk analyses","volume":"131","author":"G St\u00e5lhammar","year":"2024","journal-title":"Ophthalmology"},{"issue":"4","key":"pone.0328360.ref036","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.ophtha.2023.10.026","article-title":"Improved staging of ciliary body and choroidal melanomas based on estimation of tumor volume and competing risk analyses","volume":"131","author":"G St\u00e5lhammar","year":"2024","journal-title":"Ophthalmology"},{"issue":"2","key":"pone.0328360.ref037","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/eye.2016.275","article-title":"Uveal melanoma: relatively rare but deadly cancer","volume":"31","author":"S Kaliki","year":"2017","journal-title":"Eye (Lond)"},{"issue":"2","key":"pone.0328360.ref038","doi-asserted-by":"crossref","first-page":"208","DOI":"10.5301\/ejo.5000200","article-title":"Influence of age on prognosis of young patients with uveal melanoma: a matched retrospective cohort study","volume":"23","author":"S Kaliki","year":"2013","journal-title":"Eur J Ophthalmol"},{"key":"pone.0328360.ref039","article-title":"Predicting malignant transformation of choroidal nevi using machine learning","author":"SP Iddir","year":"2023","journal-title":"Res Sq"},{"issue":"1","key":"pone.0328360.ref040","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3390\/cancers14010096","article-title":"Prognostic biomarkers in uveal melanoma: the status quo, recent advances and future directions","volume":"14","author":"NJ Lamas","year":"2021","journal-title":"Cancers (Basel)"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0328360","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T17:21:37Z","timestamp":1755624097000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0328360"}},"subtitle":[],"editor":[{"given":"Parisa","family":"Fallahtafti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,8,19]]},"references-count":40,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0328360","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,19]]}}}