{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T18:16:29Z","timestamp":1759515389585,"version":"build-2065373602"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>A total of 40 cases of Kawasaki Disease (KD), diagnosed &amp; categorized on the basis of criteria set by the American Heart Association were studied. We sought to evaluate their clinical and laboratory analysis along with their treatment.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>After inclusion, they underwent thorough clinical and laboratory analysis and were treated with intravenous immunoglobulin and aspirin. Their clinical &amp; laboratory findings and treatment outcome were analyzed further using Epi info and at a probability of (p value) &lt; 0.05, was considered statistically significant.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The mean age of the cases was 4.1\u2009\u00b1\u20092.9 years and boys outnumber the girls (57% vs. 43%). Most (65%) of the cases were incomplete KD compared to 35% as complete KD. The mean duration of fever was 11.7\u2009\u00b1\u20095.53 days. The frequency of the different classic clinical findings of KD were- cracking of lips &amp; redness of oral cavity (72%), polymorphous skin rash (50%), conjunctival injection (45%), changes in the distal extremities (38%), cervical lymphadenitis (30%) and erythema on BCG scar (7.5%). High C-Reactive protein (CRP\u2009&gt;\u200910 mg\/dl), thrombocytosis, anaemia and leukocytosis were 85%, 45%, 43%, 38% respectively. Echocardiography showed coronary artery abnormalities (CAA) dilatation and aneurysm in 82.5% and 12.5% cases respectively which came down to 68% and 10% after receiving treatment with IVIg and Aspirin.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion &amp; Recommendation<\/jats:title>\n<jats:p>Diagnosis of KD is essentially clinical and criteria-based and 95% were complicated with CAA. Timely intervention with IVIG was mostly effective. Therefore, high index of suspicion of a long-continued febrile child is recommended to reach the diagnosis and to initiate timely intervention so as to potentially prevent CAA.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0328443","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T17:31:50Z","timestamp":1759512710000},"page":"e0328443","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical &amp; laboratory profiles and treatment outcome of Kawasaki disease in children: Experience from a tertiary care hospital"],"prefix":"10.1371","volume":"20","author":[{"given":"Shareen","family":"Khan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md Abid 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