{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:23:58Z","timestamp":1792596238369,"version":"4.5.0"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec031\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypertensive disorders of pregnancy affect about 10% of all pregnant women worldwide. A variety of hematological abnormalities may occur in women with pregnancy-induced hypertension. Thus, we aimed to compare coagulation profiles and platelet parameters among preeclampsia, eclampsia, and normotensive pregnant women in Northwest Ethiopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec032\">\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A comparative cross-sectional study was conducted at University of Gondar and Felegehiwot Comprehensive Specialized Hospital, maternity wards from June 20 to November 15, 2024. A total of 180 participants were recruited using the convenience sampling technique. Socio-demographic and clinical data were collected using a structured questionnaire and participants\u2019 medical records. Eight milliliters of blood specimens were collected from each study participant. Coagulation profiles and platelet parameters were measured using a Genrui coagulation analyzer and an automated Mindray BC-5150 hematological analyzer, respectively. Data were entered into epi-data version 4.6.0.6 and exported to the SPSS version 26 software for analysis. Descriptive data were presented using tables and frequencies. One-way ANOVA and Kruskal-Wallis tests were used for normally distributed and skewed data, respectively. A p\u2009&lt;\u20090.05 was considered statistically significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec033\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 180 pregnant women were enrolled\/included in this study. The median PT and aPTT showed prolongation in preeclampsia and eclampsia patients, as compared to normotensive pregnant women, indicating a significant difference (p\u2009&lt;\u20090.001) and (P\u2009=\u20090.002) respectively. The mean\u2009\u00b1\u2009SD of mean platelet volume and PDW showed higher values in preeclampsia and eclampsia patients, as compared to normotensive pregnant women, demonstrating both a significant difference (P\u2009&lt;\u20090.001). On the other hand, the mean platelet count in preeclampsia and eclampsia patients, were lower than in normotensive pregnant women, with a significant difference (p\u2009&lt;\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec034\">\n                    <jats:title>Conclusion and recommendations<\/jats:title>\n                    <jats:p>In this study, alteration of coagulation and platelet parameters were observed in preeclampsia and eclampsia pregnant womens compared to normotensive controls. Thus, a routine laboratory test of coagulation and platelet parameters for pregnant women with preeclampsia and eclampsia could be applicable to reduce the risk of coaglation and platelet abnormalities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0328578","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T17:34:19Z","timestamp":1753119259000},"page":"e0328578","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Coagulation profiles and platelet parameters among preeclampsia, eclampsia, and normotensive pregnant women attending Comprehensive Specialized Hospital maternity wards, Northwest Ethiopia"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0008-0605","authenticated-orcid":true,"given":"Nigusie","family":"Alemu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bisrat Birke","family":"Teketelew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sintayehu","family":"Admas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyusira","family":"Marelgn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalweayker","family":"Eyayu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berhanu","family":"Woldu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"issue":"7","key":"pone.0328578.ref001","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.mpaic.2019.05.001","article-title":"Physiology of pregnancy","volume":"20","author":"A Mockridge","year":"2019","journal-title":"Anaesth Intensive Care 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