{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:44:35Z","timestamp":1792446275180,"version":"4.5.0"},"reference-count":98,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013232","name":"Stiftelsen Norsk Luftambulanse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013232","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Both cardiopulmonary resuscitation (CPR) and ischaemia could lead to abdominal organ injury. However, the importance of abdominal injury in cardiac arrest remains uncertain. We aimed to systematically review indexed literature to describe incidence of abdominal injury after non-traumatic cardiac arrest and associations with outcome.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>We searched MEDLINE\/PubMed, Embase, The Cochrane Database of Systematic Reviews and Scopus up to 12<jats:sup>th<\/jats:sup> September 2024 for studies reporting differences in outcomes between patients with and without abdominal injury, and all studies reporting abdominal adverse events after cardiac arrest. Two independent reviewers screened articles for eligibility. One reviewer extracted data and assessed risk of bias using the Critical Appraisal Skills Programme checklist. Injuries were defined as traumatic or ischaemic, either in the studies or otherwise by the reviewers. Results were summarized and presented in tables and Forest plots. We followed the PRISMA guidelines, and registered the study in PROSPERO.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>We included 68 studies and 140 case reports. Most studies were single-centre. Quantitative synthesis of evidence was not feasible given high heterogeneity and risk of bias. Traumatic injuries affected mostly liver and spleen, with incidences from 0% to 15%, reaching 29% in one study of mechanical chest compressions. Life-threatening injuries were uncommon. The incidence of ischaemic injury was dependent on assessment method; 7% to 28% had liver injury, 0.7% to 2.5% was diagnosed with non-occlusive mesenteric ischaemia, 82% to 100% had intestinal injury measured by biomarkers. Ischaemic injuries were associated with mortality.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>In this comprehensive review of abdominal injuries following cardiac arrest, CPR-related traumatic injuries were uncommon, but should be considered in patients with unexplained clinical deterioration. Ischaemic injury incidence ranged from 0.7% to 100%, and was consistently associated with mortality. Whether abdominal ischaemia independently contributes to poor outcomes remains unresolved and warrants further investigation.<\/jats:p>\n<jats:p>PROSPERO ID: CRD42022311508.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0329164","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T17:46:41Z","timestamp":1754070401000},"page":"e0329164","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Abdominal organ injury in cardiac arrest: Systematic literature review"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4015-9089","authenticated-orcid":true,"given":"Bj\u00f8rn","family":"Hoftun Farbu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jostein","family":"Hagemo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Rehn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,8,1]]},"reference":[{"key":"pone.0329164.ref001","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.resuscitation.2021.02.012","article-title":"European Resuscitation Council and European Society of Intensive Care Medicine Guidelines 2021: Post-resuscitation care","volume":"161","author":"JP Nolan","year":"2021","journal-title":"Resuscitation"},{"key":"pone.0329164.ref002","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.resuscitation.2019.02.038","article-title":"Hypoxic liver injury after in- and out-of-hospital cardiac arrest: Risk factors and neurological outcome","volume":"137","author":"K Roedl","year":"2019","journal-title":"Resuscitation"},{"key":"pone.0329164.ref003","doi-asserted-by":"crossref","first-page":"110136","DOI":"10.1016\/j.resuscitation.2024.110136","article-title":"Acute liver failure after out-of-hospital cardiac arrest: An observational study","volume":"197","author":"M-C Delignette","year":"2024","journal-title":"Resuscitation"},{"issue":"1","key":"pone.0329164.ref004","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13054-022-03939-9","article-title":"Ischemic injury of the upper gastrointestinal tract after out-of-hospital cardiac arrest: a prospective, multicenter study","volume":"26","author":"D Grimaldi","year":"2022","journal-title":"Crit Care"},{"issue":"5","key":"pone.0329164.ref005","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/SHK.0000000000000440","article-title":"Enterocyte Damage: A Piece in the Puzzle of Post-Cardiac Arrest Syndrome","volume":"44","author":"G Piton","year":"2015","journal-title":"Shock"},{"key":"pone.0329164.ref006","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.resuscitation.2020.05.046","article-title":"Epinephrine treatment but not time to ROSC is associated with intestinal injury in patients with cardiac arrest","volume":"155","author":"KA Krychtiuk","year":"2020","journal-title":"Resuscitation"},{"key":"pone.0329164.ref007","doi-asserted-by":"crossref","first-page":"109748","DOI":"10.1016\/j.resuscitation.2023.109748","article-title":"Intestinal injury in cardiac arrest is associated with multiple organ dysfunction: A prospective cohort study","volume":"185","author":"B Hoftun Farbu","year":"2023","journal-title":"Resuscitation"},{"issue":"2","key":"pone.0329164.ref008","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0300-9572(02)00007-2","article-title":"Resuscitation from cardiac arrest with adrenaline\/epinephrine or vasopressin: effects on intestinal mucosal tonometer pCO(2) during the postresuscitation period in rats","volume":"53","author":"W Studer","year":"2002","journal-title":"Resuscitation"},{"issue":"1","key":"pone.0329164.ref009","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0300-9572(98)00078-1","article-title":"Splanchnic and renal blood flow after cardiopulmonary resuscitation with epinephrine and vasopressin in pigs","volume":"38","author":"AW Prengel","year":"1998","journal-title":"Resuscitation"},{"issue":"3","key":"pone.0329164.ref010","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.resuscitation.2009.11.023","article-title":"Gastric perforation after cardiopulmonary resuscitation: review of the literature","volume":"81","author":"I Spoormans","year":"2010","journal-title":"Resuscitation"},{"issue":"7","key":"pone.0329164.ref011","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"D Moher","year":"2009","journal-title":"PLoS Med"},{"key":"pone.0329164.ref012","unstructured":"Covidence. covidence.org Melbourne, Australia: Covidence; 2020 [cited 2020 11.05.20]. Available from: covidence.org"},{"key":"pone.0329164.ref013","unstructured":"Critical Appraisal Skills Programme 2020 [cited 2020 11.05.20]. Available from: casp-uk.net"},{"key":"pone.0329164.ref014","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.resuscitation.2018.04.022","article-title":"Major traumatic complications after out-of-hospital cardiac arrest: Insights from the Parisian registry","volume":"128","author":"B Champigneulle","year":"2018","journal-title":"Resuscitation"},{"issue":"2","key":"pone.0329164.ref015","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1046\/j.1365-2796.2003.01079.x","article-title":"Major bleeding complications after cardiopulmonary resuscitation: impact of thrombolytic treatment","volume":"253","author":"I Kurkciyan","year":"2003","journal-title":"J Intern Med"},{"issue":"3","key":"pone.0329164.ref016","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1001\/archinte.1982.00340160080018","article-title":"Medical complications of cardiopulmonary arrest","volume":"142","author":"RJ Bjork","year":"1982","journal-title":"Arch Intern Med"},{"key":"pone.0329164.ref017","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.resuscitation.2021.12.036","article-title":"CPR-related injuries after non-traumatic out-of-hospital cardiac arrest: Survivors versus non-survivors","volume":"171","author":"J Karasek","year":"2022","journal-title":"Resuscitation"},{"key":"pone.0329164.ref018","doi-asserted-by":"crossref","first-page":"109898","DOI":"10.1016\/j.resuscitation.2023.109898","article-title":"Diagnostic yield of computed tomography after non-traumatic out-of-hospital cardiac arrest","volume":"189","author":"J Tam","year":"2023","journal-title":"Resuscitation"},{"issue":"1","key":"pone.0329164.ref019","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s10140-019-01723-x","article-title":"Early whole-body CT for treatment guidance in patients with return of spontaneous circulation after cardiac arrest","volume":"27","author":"S Viniol","year":"2020","journal-title":"Emerg Radiol"},{"issue":"2","key":"pone.0329164.ref020","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s11739-015-1353-y","article-title":"Early computed tomography in victims of non-traumatic out-of-hospital cardiac arrest","volume":"11","author":"M Christ","year":"2016","journal-title":"Intern Emerg Med"},{"issue":"4","key":"pone.0329164.ref021","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/acem.14228","article-title":"Early head-to-pelvis computed tomography in out-of-hospital circulatory arrest without obvious etiology","volume":"28","author":"KRH Branch","year":"2021","journal-title":"Acad Emerg Med"},{"issue":"10","key":"pone.0329164.ref022","doi-asserted-by":"crossref","first-page":"4122","DOI":"10.1007\/s00330-017-5117-0","article-title":"Use of whole body CT to detect patterns of CPR-related injuries after sudden cardiac arrest","volume":"28","author":"GM Dunham","year":"2018","journal-title":"Eur Radiol"},{"issue":"3","key":"pone.0329164.ref023","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0196-0644(97)70342-1","article-title":"Detection of traumatic complications of cardiopulmonary resuscitation by ultrasound","volume":"29","author":"SW Corbett","year":"1997","journal-title":"Ann Emerg Med"},{"key":"pone.0329164.ref024","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.resuscitation.2015.11.004","article-title":"Comparison of complications secondary to cardiopulmonary resuscitation between out-of-hospital cardiac arrest and in-hospital cardiac arrest","volume":"98","author":"MK Seung","year":"2016","journal-title":"Resuscitation"},{"issue":"6","key":"pone.0329164.ref025","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.resuscitation.2013.02.015","article-title":"Deeper chest compression - more complications for cardiac arrest patients?","volume":"84","author":"H Hellevuo","year":"2013","journal-title":"Resuscitation"},{"issue":"10","key":"pone.0329164.ref026","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1590\/1806-9282.20220822","article-title":"Relationship between measures of thoracic diameter and cardiopulmonary resuscitation-induced thoracoabdominal injury","volume":"68","author":"TB \u00dcmit","year":"2022","journal-title":"Rev Assoc Med Bras (1992)"},{"issue":"5","key":"pone.0329164.ref027","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s10140-014-1218-0","article-title":"Thoraco-abdominal CT examinations for evaluating cause of cardiac arrest and complications of chest compression in resuscitated patients","volume":"21","author":"SJ Choi","year":"2014","journal-title":"Emerg Radiol"},{"key":"pone.0329164.ref028","doi-asserted-by":"crossref","first-page":"101828","DOI":"10.1016\/j.legalmed.2020.101828","article-title":"Aging is only significant factor causing CPR-induced injuries and serious 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Lek"},{"issue":"9","key":"pone.0329164.ref034","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1001\/archinte.1986.00360210099015","article-title":"Unexpected findings and complications at autopsy after cardiopulmonary resuscitation (CPR)","volume":"146","author":"SE Bedell","year":"1986","journal-title":"Arch Intern Med"},{"issue":"10","key":"pone.0329164.ref035","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.resuscitation.2009.06.010","article-title":"No difference in autopsy detected injuries in cardiac arrest patients treated with manual chest compressions compared with mechanical compressions with the LUCAS device--a pilot study","volume":"80","author":"D Smekal","year":"2009","journal-title":"Resuscitation"},{"issue":"6","key":"pone.0329164.ref036","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1111\/aas.13347","article-title":"Prehospital cardiopulmonary resuscitation with manual or mechanical chest compression: A study of compression\u2010induced injuries","volume":"63","author":"L Milling","year":"2019","journal-title":"Acta Anaesthesiol Scand"},{"key":"pone.0329164.ref037","doi-asserted-by":"crossref","first-page":"109244","DOI":"10.1016\/j.ejrad.2020.109244","article-title":"Comparison of different resuscitation methods with regard to injury patterns in cardiac arrest survivors based on computer tomography","volume":"131","author":"S Viniol","year":"2020","journal-title":"Eur J Radiol"},{"issue":"5","key":"pone.0329164.ref038","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s00414-015-1146-x","article-title":"Traumatic injuries after mechanical cardiopulmonary resuscitation (LUCAS2): a forensic autopsy study","volume":"129","author":"C Lardi","year":"2015","journal-title":"Int J Legal Med"},{"issue":"4","key":"pone.0329164.ref039","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1111\/1556-4029.12146","article-title":"Manual and automated cardiopulmonary resuscitation (CPR): 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compression-associated injuries in cardiac arrest patients treated with manual chest compressions versus automated chest compression devices (LUCAS II) - a forensic autopsy-based comparison","volume":"14","author":"B Ondruschka","year":"2018","journal-title":"Forensic Sci Med Pathol"},{"key":"pone.0329164.ref043","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.resuscitation.2015.08.013","article-title":"Effects of mechanical chest compression device with a load-distributing band on post-resuscitation injuries identified by post-mortem computed tomography","volume":"96","author":"Y Koga","year":"2015","journal-title":"Resuscitation"},{"issue":"12","key":"pone.0329164.ref044","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1016\/j.resuscitation.2014.09.017","article-title":"CPR-related injuries after manual or mechanical chest compressions with the LUCAS\u2122 device: a multicentre study of victims after unsuccessful resuscitation","volume":"85","author":"D Smekal","year":"2014","journal-title":"Resuscitation"},{"issue":"3","key":"pone.0329164.ref045","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.resuscitation.2007.05.007","article-title":"Cardiac arrest with continuous mechanical chest compression during percutaneous coronary intervention. A report on the use of the LUCAS device","volume":"75","author":"AI Larsen","year":"2007","journal-title":"Resuscitation"},{"issue":"7","key":"pone.0329164.ref046","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1001\/jama.1978.03290070046013","article-title":"External cardiac compression. A randomized comparison of mechanical and manual techniques","volume":"240","author":"GJ Taylor","year":"1978","journal-title":"JAMA"},{"issue":"3","key":"pone.0329164.ref047","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.resuscitation.2007.05.023","article-title":"Cardiopulmonary resuscitation-associated major liver injury","volume":"75","author":"G Meron","year":"2007","journal-title":"Resuscitation"},{"issue":"11","key":"pone.0329164.ref048","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0206655","article-title":"Acute liver dysfunction after cardiac arrest","volume":"13","author":"E Iesu","year":"2018","journal-title":"PLoS One"},{"issue":"9","key":"pone.0329164.ref049","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.ajem.2015.05.008","article-title":"Hypoxic hepatitis in survivors of out-of-hospital cardiac arrest","volume":"33","author":"SH Oh","year":"2015","journal-title":"Am J Emerg 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Paul","year":"2020","journal-title":"Resuscitation"},{"issue":"1","key":"pone.0329164.ref056","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.resuscitation.2012.06.010","article-title":"Markers of intestinal injury are associated with endotoxemia in successfully resuscitated patients","volume":"84","author":"D Grimaldi","year":"2013","journal-title":"Resuscitation"},{"key":"pone.0329164.ref057","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.resuscitation.2019.11.024","article-title":"Early full-body computed tomography in patients after extracorporeal cardiopulmonary resuscitation (eCPR)","volume":"146","author":"V Zotzmann","year":"2020","journal-title":"Resuscitation"},{"issue":"3","key":"pone.0329164.ref058","doi-asserted-by":"crossref","DOI":"10.23736\/S0393-3660.17.03500-8","article-title":"Effects of extracorporeal cardiopulmonary resuscitation complications on resuscitation outcomes","volume":"177","author":"T Maruhashi","year":"2018","journal-title":"Gazz Med Ital - Arch Sci Med"},{"key":"pone.0329164.ref059","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.resuscitation.2018.08.030","article-title":"Surviving refractory out-of-hospital ventricular fibrillation cardiac arrest: Critical care and extracorporeal membrane oxygenation management","volume":"132","author":"JA Bartos","year":"2018","journal-title":"Resuscitation"},{"issue":"1","key":"pone.0329164.ref060","first-page":"62","article-title":"Acute mesenteric ischaemia in refractory shock on veno-arterial extracorporeal membrane oxygenation","volume":"10","author":"M Renaudier","year":"2020","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"issue":"9","key":"pone.0329164.ref061","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.3390\/jcm9092994","article-title":"The Impact of Hypoxic Hepatitis on Clinical Outcomes after Extracorporeal Cardiopulmonary Resuscitation","volume":"9","author":"YI Lee","year":"2020","journal-title":"J Clin Med"},{"key":"pone.0329164.ref062","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.resuscitation.2021.04.029","article-title":"Outcomes associated with delayed enteral feeding after cardiac arrest treated with veno-arterial extracorporeal membrane oxygenation and targeted temperature management","volume":"164","author":"A Gutierrez","year":"2021","journal-title":"Resuscitation"},{"issue":"8","key":"pone.0329164.ref063","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.hlc.2016.11.022","article-title":"Therapeutic Hypothermia May Improve Neurological Outcomes in Extracorporeal Life Support for Adult Cardiac Arrest","volume":"26","author":"PYK Pang","year":"2017","journal-title":"Heart Lung Circ"},{"issue":"11","key":"pone.0329164.ref064","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.resuscitation.2014.08.028","article-title":"Extracorporeal life support as rescue strategy for out-of-hospital 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Howard","year":"1987","journal-title":"Ann Emerg Med"},{"issue":"1","key":"pone.0329164.ref074","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0300-9572(90)90088-V","article-title":"Cardiopulmonary resuscitation with simultaneous chest and abdominal compression: comparative study in humans","volume":"20","author":"F Barranco","year":"1990","journal-title":"Resuscitation"},{"issue":"6","key":"pone.0329164.ref075","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1161\/01.CIR.86.6.1692","article-title":"Interposed abdominal compression-cardiopulmonary resuscitation and resuscitation outcome during asystole and electromechanical dissociation","volume":"86","author":"JB Sack","year":"1992","journal-title":"Circulation"},{"key":"pone.0329164.ref076","unstructured":"Deeks JJ HJ, Altman DG (editors). Chapter 10: Analysing data and undertaking meta-analyses. Cochrane Handbook for Systematic Reviews of Interventions version 64 (updated August 2023). 2023."},{"issue":"10","key":"pone.0329164.ref077","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1016\/j.injury.2022.06.020","article-title":"Epidemiology of abdominal trauma: An age- and sex-adjusted incidence analysis with mortality patterns","volume":"53","author":"J Wiik Larsen","year":"2022","journal-title":"Injury"},{"key":"pone.0329164.ref078","doi-asserted-by":"crossref","DOI":"10.1016\/j.resuscitation.2020.09.012","article-title":"Adult Advanced Life Support: 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations","volume":"156","author":"J Soar","year":"2020","journal-title":"Resuscitation"},{"issue":"6","key":"pone.0329164.ref079","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.resuscitation.2014.01.028","article-title":"A systematic review and pooled analysis of CPR-associated cardiovascular and thoracic injuries","volume":"85","author":"AC Miller","year":"2014","journal-title":"Resuscitation"},{"issue":"22","key":"pone.0329164.ref080","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1001\/jama.295.22.2620","article-title":"Manual chest compression vs use of an automated chest compression device during resuscitation following out-of-hospital cardiac arrest: a randomized trial","volume":"295","author":"A Hallstrom","year":"2006","journal-title":"JAMA"},{"issue":"6","key":"pone.0329164.ref081","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.resuscitation.2014.03.005","article-title":"Manual vs. integrated automatic load-distributing band CPR with equal survival after out of hospital cardiac arrest. 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Management of the Diseases of Mesenteric Arteries and Veins: Clinical Practice Guidelines of the European Society of Vascular Surgery (ESVS)","volume":"53","author":"M Bj\u00f6rck","year":"2017","journal-title":"Eur J Vasc Endovasc Surg"},{"issue":"9","key":"pone.0329164.ref087","first-page":"989","article-title":"Acute kidney injury after cardiac arrest: a systematic review and meta-analysis of clinical studies","volume":"82","author":"C Sandroni","year":"2016","journal-title":"Minerva Anestesiol"},{"key":"pone.0329164.ref088","doi-asserted-by":"crossref","first-page":"100972","DOI":"10.1016\/j.resplu.2025.100972","article-title":"Intestinal fatty acid-binding protein as a marker of prognosis and non-occlusive mesenteric ischemia in refractory cardiac arrest patients: a pilot study","volume":"24","author":"J Smalcova","year":"2025","journal-title":"Resusc Plus"},{"issue":"1","key":"pone.0329164.ref089","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s13054-020-02889-4","article-title":"Gastrointestinal dysfunction in the critically ill: a systematic scoping review and research agenda proposed by the Section of Metabolism, Endocrinology and Nutrition of the European Society of Intensive Care Medicine","volume":"24","author":"A Reintam Blaser","year":"2020","journal-title":"Crit Care"},{"issue":"3","key":"pone.0329164.ref090","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1365-2796.2006.01613.x","article-title":"Fatal nonocclusive mesenteric ischaemia: population-based incidence and risk factors","volume":"259","author":"S Acosta","year":"2006","journal-title":"J Intern Med"},{"issue":"12","key":"pone.0329164.ref091","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1007\/s00134-024-07641-y","article-title":"Clinical vs. autopsy diagnostic discrepancies in the intensive care unit: a systematic review and meta-analysis of autopsy series","volume":"50","author":"B Marcoen","year":"2024","journal-title":"Intensive Care Med"},{"key":"pone.0329164.ref092","doi-asserted-by":"crossref","first-page":"110642","DOI":"10.1016\/j.resuscitation.2025.110642","article-title":"The significance of possible non-occlusive mesenteric ischemia in relation to neurological outcomes in patients with refractory cardiac arrest - Secondary analysis of the Prague OHCA study","volume":"214","author":"J Smalcova","year":"2025","journal-title":"Resuscitation"},{"issue":"19","key":"pone.0329164.ref093","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1161\/CIRCULATIONAHA.120.053318","article-title":"Treatment Effects of Interleukin-6 Receptor Antibodies for Modulating the Systemic Inflammatory Response After Out-of-Hospital Cardiac Arrest (The IMICA Trial): A Double-Blinded, Placebo-Controlled, Single-Center, Randomized, Clinical Trial","volume":"143","author":"MAS Meyer","year":"2021","journal-title":"Circulation"},{"issue":"12","key":"pone.0329164.ref094","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1007\/s00134-023-07247-w","article-title":"Prehospital high-dose methylprednisolone in resuscitated out-of-hospital cardiac arrest patients (STEROHCA): a randomized clinical trial","volume":"49","author":"LER Obling","year":"2023","journal-title":"Intensive Care Med"},{"issue":"16","key":"pone.0329164.ref095","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1001\/jama.2021.16628","article-title":"Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest: A Randomized Clinical Trial","volume":"326","author":"LW Andersen","year":"2021","journal-title":"JAMA"},{"key":"pone.0329164.ref096","doi-asserted-by":"crossref","first-page":"100639","DOI":"10.1016\/j.resplu.2024.100639","article-title":"The detrimental effects of intestinal injury mediated by inflammation are limited in cardiac arrest patients: A prospective cohort study","volume":"18","author":"BH Farbu","year":"2024","journal-title":"Resusc Plus"},{"issue":"1","key":"pone.0329164.ref097","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1186\/s13063-021-05477-1","article-title":"REBOARREST, resuscitative endovascular balloon occlusion of the aorta in non-traumatic out-of-hospital cardiac arrest: a study protocol for a randomised, parallel group, clinical multicentre trial","volume":"22","author":"JR Brede","year":"2021","journal-title":"Trials"},{"issue":"1","key":"pone.0329164.ref098","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13063-024-07928-x","article-title":"Effect of resuscitative endovascular balloon occlusion of the aorta in nontraumatic out-of-hospital cardiac arrest: a multinational, multicenter, randomized, controlled trial","volume":"25","author":"HE Kim","year":"2024","journal-title":"Trials"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0329164","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T17:46:54Z","timestamp":1754070414000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0329164"}},"subtitle":[],"editor":[{"given":"Nik Hisamuddin","family":"Nik Ab. 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