{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T15:09:09Z","timestamp":1782140949901,"version":"3.54.5"},"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Laboratory of Health Cultivation of Traditional Chinese Medicine, Beijing University of Chinese Medicine"},{"name":"Creation and Talent Introduction Base for Universities, Ministry of Education","award":["B20055"],"award-info":[{"award-number":["B20055"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Large-sample clinical research evidence in humans regarding the association between thyroid hormones and cardiovascular health is limited. The American Heart Association introduced the Life\u2019s Essential 8 (LE8) as a novel metric for assessing cardiovascular health. This study aimed to explore the plausible connection between thyroid hormone levels and LE8.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study employed data extracted from the National Health and Nutrition Examination Survey spanning from 2007\u20132012, focusing on individuals aged 20 and above. To investigate the association between thyroid hormone and LE8, diverse analytical methods, including weighted multivariate linear regression, restricted cubic spline curves, and stratified analysis, were utilized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 3,019 participants were enrolled in this study. The highest LE8 score group (\u2265 80) comprised 610 participants (20.21%). In the fully adjusted linear regression analysis, elevated levels of ln(FT3), ln(TT3), and ln(Tg) were significantly associated with a reduced level of LE8 (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      (95% Confidence Interval): \u22126.31 (\u221212.13, \u22120.49), p\u2009=\u20090.035; \u22125.18 (\u22128.22, \u22122.15), p\u2009=\u20090.002; \u22120.98 (\u22121.74, \u22120.22), p\u2009=\u20090.014). The analysis revealed nonlinear relationships between ln(Tg), ln(TgAb), ln(TPOAb), and LE8. In the group with normal thyroid hormone levels, ln(TT3), ln(TT4), and ln(Tg) correlated with LE8 in the stratified analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Alterations in FT3, TT3, TT4, Tg, TgAb, and TPOAb levels correlated with variations in LE8. Adherence to cardiovascular health recommendations may be pertinent to the preservation of thyroid health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0329194","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T17:29:46Z","timestamp":1761326986000},"page":"e0329194","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between thyroid hormone and cardiovascular health: A cross-sectional 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