{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T19:26:10Z","timestamp":1754162770426,"version":"3.41.2"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Purpose<\/jats:title>\n<jats:p>Residual myopia following Laser-assisted in situ keratomileusis (LASIK) surgery poses a significant concern, with existing literature extensively detailing the use of timolol for treatment. This study aims to assess prediction factors for brimonidine tartrate 0.15% (Alphagan-P) response on post-LASIK residual myopic refraction reduction.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>The study included consecutive patients who received Alphagan-P during their follow-up for post-LASIK residual myopia.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>We included 61 patients (55% male) with a mean age of 35.18\u2009\u00b1\u200910.13 Alphagan-P Treatment started at a mean of 4.94\u2009\u00b1\u20095.64 months after surgery for residual myopia of \u22120.53\u2009\u00b1\u20090.71D. Comparison analysis of patients who responded (n\u2009=\u200932, 51.6%) to patients who did not (n\u2009=\u200930, 48.4%) shows that responders were older (38.1\u2009\u00b1\u20099.1 vs. 32.3\u2009\u00b1\u200910.3, p\u2009=\u20090.03), had higher baseline myopic Spherical equivalent (SE, \u22120.82\u2009\u00b1\u20090.65 vs. \u22120.26\u2009\u00b1\u20090.66 p\u2009&lt;\u20090.01), and lower uncorrected visual acuity (Uncorrected visual acuity [UCVA], 0.14\u2009\u00b1\u20090.2 vs. \u22120.003\u2009\u00b1\u20090.12 p\u2009=\u20090.01). Multiple Binary logistic regression confirmed these predictors for response (UCVA (OR=70.6, <jats:italic><jats:italic>P<\/jats:italic><\/jats:italic>\u2009=\u2009.006), larger SE (OR=3.8, <jats:italic><jats:italic>P<\/jats:italic><\/jats:italic>\u2009=\u2009.004,) and older age (OR=1.06, <jats:italic><jats:italic>P<\/jats:italic><\/jats:italic>\u2009=\u2009.03)).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Alphagan-P can reduce up to 0.5D of post-LASIK residual myopia in roughly 50% of subjects. This treatment might be recommended to fine-tune outcomes for low residual myopia.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0329364","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T17:24:33Z","timestamp":1753896273000},"page":"e0329364","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Brimonidine tartrate 0.15% drops to reduce low post-LASIK residual myopia: A retrospective 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