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During psychotherapy, HF-HRV changed more in AN and BN groups than in HC or mixed samples. sC and sAA remained unchanged. There was no association between BMI and stress physiology.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Alterations in stress physiology present differently across EDs and mixed mental disorders. Correlates of physiological functioning remained mostly stable throughout 3 months of psychotherapy. Only basal vagal tone was normalized in AN\/BN in comparison to HC. This might indicate that physiological changes can occur early, but mostly take longer to change during treatment.<\/jats:p>\n<jats:p><jats:bold>Trial registration:<\/jats:bold> Data were assessed during a multi-site cross- and longitudinal experimental trial registered at the German Clinical Trials Registry (trial number: DRKS00005709; see [1] for details).<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0329573","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T17:31:47Z","timestamp":1757352707000},"page":"e0329573","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Resting vagal tone, alpha amylase and cortisol levels in women with eating disorders before and after 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Antelmi","year":"2004","journal-title":"Am J Cardiol"},{"key":"pone.0329573.ref033","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.psyneuen.2008.07.004","article-title":"Elevated alpha amylase but not cortisol in generalized social anxiety disorder","volume":"33","author":"JF Van Veen","year":"2008","journal-title":"Psychoneuroendocrinology"},{"key":"pone.0329573.ref034","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.psychres.2015.11.021","article-title":"Salivary alpha amylase levels in youths with anxiety disorders","volume":"235","author":"O Yorbik","year":"2016","journal-title":"Psychiatry Res"},{"issue":"3","key":"pone.0329573.ref035","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.biopsycho.2009.12.007","article-title":"Sympathetic arousal moderates self-reported physiological arousal symptoms at baseline and physiological flexibility in response to a stressor in generalized anxiety disorder","volume":"83","author":"AJ Fisher","year":"2010","journal-title":"Biol Psychol"},{"key":"pone.0329573.ref036","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3389\/fpsyg.2015.00261","article-title":"Resting heart rate variability predicts self-reported difficulties in emotion regulation: a focus on different facets of emotion regulation","volume":"6","author":"DP Williams","year":"2015","journal-title":"Front Psychol"},{"key":"pone.0329573.ref037","doi-asserted-by":"crossref","first-page":"726","DOI":"10.3389\/fpsyt.2020.00726","article-title":"Treatment-Resistant Blunted HPA Activity, but Reversible Cardiovascular Stress Reactivity in Young Women With Eating Disorders","volume":"11","author":"S Het","year":"2020","journal-title":"Front Psychiatry"},{"issue":"3","key":"pone.0329573.ref038","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1017\/bec.2014.14","article-title":"Investigating the Effect of Mindfulness Training on Heart Rate Variability in Mental Health Outpatients: A Pilot 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Achse I und II. Handanweisung","year":"1997","author":"HU Wittchen","key":"pone.0329573.ref045"},{"issue":"6","key":"pone.0329573.ref046","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/eat.22487","article-title":"The eating disorder examination-questionnaire 8: A brief measure of eating disorder psychopathology (EDE-Q8)","volume":"49","author":"S Kliem","year":"2016","journal-title":"Int J Eat Disord"},{"issue":"6","key":"pone.0329573.ref047","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0280402","article-title":"Eating disorder treatment in routine clinical care: A descriptive study examining treatment characteristics and short-term treatment outcomes among patients with anorexia nervosa and bulimia nervosa in Germany and Switzerland","volume":"18","author":"K Schopf","year":"2023","journal-title":"PLoS One"},{"key":"pone.0329573.ref048","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-15529-1","volume-title":"DIPS: Diagnostisches Interview bei psychischen St\u00f6rungen","author":"S Schneider","year":"2011"},{"volume-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"2000","author":"American Psychiatric Association","key":"pone.0329573.ref049"},{"key":"pone.0329573.ref050","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association. 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Benjamini","year":"1995","journal-title":"J R Stat Soc Ser B"},{"issue":"3","key":"pone.0329573.ref054","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.jpsychores.2014.11.001","article-title":"Blunted neuroendocrine stress reactivity in young women with eating disorders","volume":"78","author":"S Het","year":"2015","journal-title":"J Psychosom Res"},{"issue":"2","key":"pone.0329573.ref055","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.pscychresns.2014.04.015","article-title":"Abnormal relationships between the neural response to high- and low-calorie foods and endogenous acylated ghrelin in women with active and weight-recovered anorexia nervosa","volume":"223","author":"LM Holsen","year":"2014","journal-title":"Psychiatry Res"},{"key":"pone.0329573.ref056","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1007\/s40519-022-01394-7","article-title":"Time evaluation and its accuracy in eating disorders: Differences in relation to 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