{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:21:30Z","timestamp":1755224490403,"version":"3.43.0"},"reference-count":15,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objectives<\/jats:title>\n<jats:p>Stroke is a leading cause of morbidity in the United States, which prompts an exploration into its associated risk factors. Muscle disorders have been linked to an increased risk of stroke; however, research on stroke prevalence and clinical outcomes in this population is limited by small sample sizes. Although the diagnostic and treatment protocols for acute ischemic stroke are largely identical in patients with and without muscle disorders, it remains unclear whether clinical outcomes differ. This study aimed to address this gap using a large, nationally representative dataset.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Materials and methods<\/jats:title>\n<jats:p>We conducted a retrospective analysis of the 2016\u20132022 National Inpatient Sample to compare clinical outcomes in patients with and without muscle disorders hospitalized for an acute ischemic stroke.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Patients with pre-existing muscle disorders had significantly higher rates of intubation, PEG tube placement, and in-hospital mortality, as well as a lower likelihood of discharge to home, compared to those without muscle disorders.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>These findings suggest that patients with muscle disorders experience worse outcomes following an ischemic stroke. Further research is needed to identify the underlying factors driving these disparities and to inform targeted strategies for improving outcomes in this vulnerable population.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0329631","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T17:31:52Z","timestamp":1755019912000},"page":"e0329631","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical outcomes in patients with muscle disorders and acute ischemic stroke"],"prefix":"10.1371","volume":"20","author":[{"given":"Adeel S.","family":"Zubair","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7389-0328","authenticated-orcid":true,"given":"Lauren","family":"Littig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel B.","family":"DiCapua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8178-8597","authenticated-orcid":true,"given":"Adam","family":"de Havenon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"issue":"9","key":"pone.0329631.ref001","doi-asserted-by":"crossref","DOI":"10.1161\/CIR.0000000000000757","article-title":"Heart Disease and Stroke Statistics-2020 Update: A Report From the American Heart Association","volume":"141","author":"SS Virani","year":"2020","journal-title":"Circulation"},{"key":"pone.0329631.ref002","first-page":"3238165","article-title":"Stroke in the 21st Century: A Snapshot of the Burden, Epidemiology, and Quality of Life","volume":"2018","author":"ES Donkor","year":"2018","journal-title":"Stroke Res Treat"},{"issue":"23","key":"pone.0329631.ref003","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000012943","article-title":"Acute ischemic stroke interventions in the United States and racial, socioeconomic, and geographic disparities","volume":"97","author":"A de Havenon","year":"2021","journal-title":"Neurology"},{"issue":"1","key":"pone.0329631.ref004","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41572-019-0118-8","article-title":"Ischaemic stroke","volume":"5","author":"BCV Campbell","year":"2019","journal-title":"Nat Rev Dis Primers"},{"issue":"4","key":"pone.0329631.ref005","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1161\/01.STR.18.4.805","article-title":"Frequency of cerebral infarction in patients with inherited neuromuscular diseases","volume":"18","author":"J Biller","year":"1987","journal-title":"Stroke"},{"key":"pone.0329631.ref006","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2174\/1874205X01206010026","article-title":"Stroke and Stroke-like Episodes in Muscle Disease","volume":"6","author":"J Finsterer","year":"2012","journal-title":"Open Neurol J"},{"issue":"1","key":"pone.0329631.ref007","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1159\/000255968","article-title":"Stroke in myopathies","volume":"29","author":"J Finsterer","year":"2010","journal-title":"Cerebrovasc Dis"},{"issue":"3","key":"pone.0329631.ref008","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.tips.2025.01.005","article-title":"Emerging mechanisms and therapeutics in inflammatory muscle diseases","volume":"46","author":"S Wischnewski","year":"2025","journal-title":"Trends Pharmacol Sci"},{"issue":"8","key":"pone.0329631.ref009","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1161\/STROKEAHA.116.013678","article-title":"Stroke in Duchenne Muscular Dystrophy: A Retrospective Longitudinal Study in 54 Patients","volume":"47","author":"M Winterholler","year":"2016","journal-title":"Stroke"},{"issue":"7","key":"pone.0329631.ref010","first-page":"928","article-title":"Incidence of cerebral infarction in Duchenne muscular dystrophy","volume":"19","author":"R Hanajima","year":"1996","journal-title":"Muscle Nerve"},{"key":"pone.0329631.ref011","unstructured":"CMS. ICD-10-CM Official Guidelines for Coding and Reporting. 2019. https:\/\/www.cms.gov\/Medicare\/Coding\/ICD10\/Downloads\/2019-ICD10-Coding-Guidelines-.pdf"},{"issue":"11","key":"pone.0329631.ref012","doi-asserted-by":"crossref","DOI":"10.1161\/STROKEAHA.121.035112","article-title":"Effect of Adjusting for Baseline Stroke Severity in the National Inpatient Sample","volume":"52","author":"A de Havenon","year":"2021","journal-title":"Stroke"},{"issue":"3","key":"pone.0329631.ref013","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1081\/QEN-120001878","article-title":"Model-Dependent Variance Inflation Factor Cutoff Values","volume":"14","author":"TA Craney","year":"2002","journal-title":"Quality Engineering"},{"issue":"9","key":"pone.0329631.ref014","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1002\/(SICI)1097-0258(19970515)16:9<965::AID-SIM509>3.0.CO;2-O","article-title":"A comparison of goodness-of-fit tests for the logistic regression model","volume":"16","author":"DW Hosmer","year":"1997","journal-title":"Stat Med"},{"issue":"5","key":"pone.0329631.ref015","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.jen.2012.02.011","article-title":"Missed opportunities for recognition of ischemic stroke in the emergency department","volume":"39","author":"NM Lever","year":"2013","journal-title":"J Emerg Nurs"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0329631","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T17:31:56Z","timestamp":1755019916000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0329631"}},"subtitle":[],"editor":[{"given":"Atakan","family":"Orscelik,","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,8,12]]},"references-count":15,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0329631","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,12]]}}}