{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T01:07:20Z","timestamp":1755220040179,"version":"3.43.0"},"reference-count":72,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>The wish to hasten death (WTHD) is a clinically significant phenomenon that arises from complex suffering. It has been predominantly studied in Caucasian populations, emphasizing the importance of gaining more diverse cultural perspectives. This study explores the factors associated with the WTHD in Mexican cancer patients receiving palliative care from one academic center, with a specific focus on its connection to dignity.\u201c.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Patients and methods<\/jats:title>\n<jats:p>The study, a cross-sectional research conducted between October 12, 2023, and August 30, 2024, involved patients with confirmed cancer diagnoses who were attending a palliative care service. Patients had applied the Patient Dignity Inventory (PDI), Schedule of Attitudes Toward Hastened Death (SAHD), Brief Edinburgh Depression Scale (BEDS), EORTC QLQ-C15-PAL to assess health-related quality of life, Karnofsky Performance Status Scale (KPSS) to assess functional capacity, and the Edmonton Symptom Assessment System. A PDI score \u226555 indicated a fractured sense of dignity (DPD), while a SAHD score \u22651 indicated the WTHD. Factors associated with the WTHD were identified using multiple logistic regression analysis. The study was approved by the IRB.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The study included 302 primarily middle-aged (54.5 [45\u201364]) females (225 [74.5%]), with 9 years of education. They reported high severity of well-being (7 [1\u20137]) and tiredness (3 [0\u20136]). Their median KPSS score showed independence (80 [70\u201380]), despite impacts across all EORTC QLQ-C15-PAL dimensions. DPD was noted in 110 patients (36.5%). The most frequent diagnoses were breast cancer (114 [38%]), lung cancer (33 [11%]), and gastrointestinal cancer (28 [9%]).<\/jats:p>\n<jats:p>The WTHD was found in 94 patients (31.1%). Factors significantly associated included tiredness score (OR: 1.147, 95% CI: 1.044\u20131.261, p\u2009=\u20090.004), BEDS score (1.181, 1.085\u20131.284, p\u2009\u2264\u20090.001) and a DPD (1.979, 1.038\u20133.772, p\u2009=\u20090.04).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The WTHD was found in one out of every three Mexican cancer patients receiving palliative care and was linked to biological-, mental health-, and existential-related factors.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0329736","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T17:24:24Z","timestamp":1754587464000},"page":"e0329736","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mental health-related, existential, and biological factors are associated with the desire to hasten death in Mexican cancer patients undergoing palliative care: A single-center study"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5441-1919","authenticated-orcid":true,"given":"Oscar","family":"Rodr\u00edguez-Mayoral","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edith","family":"Monreal-Carrillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iraz\u00fa","family":"Contreras-Y\u00e1\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Allende-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evandro","family":"Agazzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7368-498X","authenticated-orcid":true,"given":"Virginia","family":"Pascual-Ramos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"issue":"2","key":"pone.0329736.ref001","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpainsymman.2024.04.023","article-title":"The wish to hasten death in patients with life-limiting conditions. a systematic overview","volume":"68","author":"A Rodr\u00edguez-Prat","year":"2024","journal-title":"J Pain Symptom Manage"},{"issue":"5","key":"pone.0329736.ref002","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0037117","article-title":"What lies behind the wish to hasten death? 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