{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T11:01:22Z","timestamp":1776769282766,"version":"3.51.2"},"reference-count":60,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>Global public health is facing a real challenge due to infections caused by multidrug-resistant bacteria. Among these bacteria, <jats:italic><jats:italic>Staphylococcus aureus<\/jats:italic><\/jats:italic> is known to rapidly develops antibiotic resistance. This study aimed to evaluate the antibacterial potential of <jats:italic><jats:italic>Harungana madagascariensis<\/jats:italic><\/jats:italic> fruit extracts and their effects on the antioxidant system of multidrug-resistant <jats:italic><jats:italic>Staphylococcus aureus<\/jats:italic><\/jats:italic>. Moreover, the extracts were evaluated for their antibiotic-resistance modulation effects against some multidrug-resistant <jats:italic><jats:italic>Staphylococcus aureus<\/jats:italic><\/jats:italic>. The antibacterial activity of the extracts and their effect in combination with antibiotics were assessed using the\u00a0micro-dilution\u00a0method. The catalase activity was assessed by measuring the height of foam, whereas the lipid peroxidation was carried out through spectrophotometric quantification of malondialdehyde. The phytochemical analysis of extracts was carried out using qualitative and quantitative standard assays. The tested extracts showed antibacterial activities, with minimum inhibitory concentrations ranging from 32 to 2048 \u03bcg\/mL. The most active extract (hexane extract) has inhibited the catalase activity and induced the lipid peroxidation in <jats:italic><jats:italic>S. aureus<\/jats:italic><\/jats:italic> DO18SA, indicating its ability to interact with the antioxidant system of the bacteria. Moreover, the dichloromethane\/methanol extract increased by 2\u2013128-fold the activity of levofloxacin, ampicillin, and cefotaxime against selected multidrug-resistant <jats:italic><jats:italic>S. aureus<\/jats:italic><\/jats:italic>. It also showed synergistic effect with cefotaxime against D051SA. Alkaloids, triterpenes, and phenols were detected in all the extracts, whereas the other phytochemical classes were selectively distributed. The methanol extract had the highest phenolic content (142.20\u2009\u00b1\u200916.75\u2009mg GAE\/g of extract). Overall, the findings of this study suggest that extracts of <jats:italic><jats:italic>Harungana madagascariensis<\/jats:italic><\/jats:italic> fruits could be valuable sources of new agents for treating multidrug-resistant <jats:italic><jats:italic>Staphylococcus aureus<\/jats:italic><\/jats:italic> infections.<\/jats:p>","DOI":"10.1371\/journal.pone.0329771","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T17:38:04Z","timestamp":1754588284000},"page":"e0329771","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Anti-staphylococcal activity, antibiotic-resistance modulation effects and action of Harungana madagascariensis (Hypericaceae) fruit extracts on the antioxidant system of multidrug-resistant Staphylococcus aureus"],"prefix":"10.1371","volume":"20","author":[{"given":"Brenda Ngueffo","family":"Tiwa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7008-7453","authenticated-orcid":true,"given":"Aim\u00e9 Gabriel","family":"Fankam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line Brinda","family":"Sonfack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Mouozong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael Francis","family":"Kengne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armelle 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