{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:27:47Z","timestamp":1755217667742,"version":"3.43.0"},"reference-count":11,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Joint General Fund of Science, Health Science and Technology of Wanzhou District, Chongqing, People\u00e2\u20ac\u2122s Republic of China","award":["wzwjw-kw2024031"],"award-info":[{"award-number":["wzwjw-kw2024031"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Remimazolam, an innovative benzodiazepine, exhibits potential for use in anesthesia and sedation for pediatric outpatient procedures, due to its rapid onset, predictable metabolism, and favorable safety profile. While adult studies are increasing, comprehensive evidence for pediatric use remains limited. This scoping review aims to systematically summarize and delineate the existing evidence concerning the application and features of remimazolam in anesthesia and sedation for outpatient pediatric surgical procedures.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Objective<\/jats:title>\n<jats:p>To systematically map existing evidence on remimazolam use in pediatric ambulatory surgery anesthesia and sedation, identifying key concepts, evidence sources, and knowledge gaps.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Following JBI methodology and PRISMA-ScR guidelines, we will search multiple databases, as well as the recommendations provided in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension tailored for Scoping Reviews (PRISMA-ScR) statement. A comprehensive search will be performed using multiple databases, which include PubMed\/MEDLINE, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, CINAHL, Scopus, Google Scholar, along with Chinese databases like the China National Knowledge Infrastructure (CNKI), WanFang Data, and VIP Information.. All published studies on remimazolam use in patients \u226418 years for ambulatory surgery will be included. Two reviewers will independently screen and extract data using a standardized form.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0329861","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T17:23:46Z","timestamp":1754414626000},"page":"e0329861","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Remimazolam for anesthesia and sedation in pediatric ambulatory surgery: A scoping review protocol"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1853-9358","authenticated-orcid":true,"given":"Yi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingjun","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haishan","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8836-8672","authenticated-orcid":true,"given":"Yunbo","family":"Mo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,8,5]]},"reference":[{"issue":"1","key":"pone.0329861.ref001","doi-asserted-by":"crossref","DOI":"10.1111\/aas.14559","article-title":"Remimazolam: is the new \u201cwonder drug\u201d in anesthesia any good in children?","volume":"69","author":"TG Hansen","year":"2024","journal-title":"Acta Anaesthesiol Scand"},{"issue":"2","key":"pone.0329861.ref002","doi-asserted-by":"crossref","first-page":"384","DOI":"10.4314\/ahs.v22i2.44","article-title":"The comparison of remimazolam and midazolam for the sedation of gastrointestinal endoscopy: a meta-analysis of randomized controlled studies","volume":"22","author":"L Zhang","year":"2022","journal-title":"Afr H Sci"},{"issue":"1","key":"pone.0329861.ref003","article-title":"Safety and efficacy of remimazolam compared with midazolam during bronchoscopy: a single-center, randomized controlled study","volume":"13","author":"S-H Kim","year":"2023","journal-title":"Sci Rep"},{"issue":"5","key":"pone.0329861.ref004","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1080\/03007995.2023.2196198","article-title":"Economic benefits of remimazolam compared to midazolam and propofol for procedural sedation in colonoscopies and bronchoscopies","volume":"39","author":"MH Pedersen","year":"2023","journal-title":"Curr Med Res Opinion"},{"issue":"3","key":"pone.0329861.ref005","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/anae.16475","article-title":"Safety and efficacy of remimazolam tosilate for general anaesthesia in paediatric patients undergoing elective surgery: a multicentre, randomised, single\u2010blind, controlled trial","volume":"80","author":"Y Fang","year":"2024","journal-title":"Anaesthesia"},{"issue":"4","key":"pone.0329861.ref006","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/anae.16205","article-title":"Anaesthetic efficacy and postinduction hypotension with remimazolam compared with propofol: a multicentre randomised controlled trial","volume":"79","author":"J Fechner","year":"2024","journal-title":"Anaesthesia"},{"issue":"1","key":"pone.0329861.ref007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00540-022-03107-x","article-title":"Caution!! Reappearance of remimazolam effect after a flumazenil bolus: a larger bolus of flumazenil and a lower total remimazolam clearance are higher risks","volume":"37","author":"K Masui","year":"2022","journal-title":"J Anesth"},{"issue":"1","key":"pone.0329861.ref008","doi-asserted-by":"crossref","DOI":"10.1186\/s40981-022-00576-7","article-title":"Long-term delayed emergence after remimazolam-based general anesthesia: a case report","volume":"8","author":"T Takemori","year":"2022","journal-title":"JA Clin Rep"},{"issue":"10","key":"pone.0329861.ref009","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.11124\/JBIES-20-00167","article-title":"Updated methodological guidance for the conduct of scoping reviews","volume":"18","author":"MDJ Peters","year":"2020","journal-title":"JBI Evidence Synthesis"},{"key":"pone.0329861.ref010","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.g7647","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation","volume":"349","author":"L Shamseer","year":"2015","journal-title":"BMJ"},{"issue":"7","key":"pone.0329861.ref011","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA Extension for Scoping Reviews (PRISMA-ScR): checklist and explanation","volume":"169","author":"AC Tricco","year":"2018","journal-title":"Ann Intern Med"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0329861","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T17:23:57Z","timestamp":1754414637000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0329861"}},"subtitle":[],"editor":[{"given":"Kiyan","family":"Heybati","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,8,5]]},"references-count":11,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0329861","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2025,8,5]]}}}