{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:50:03Z","timestamp":1790304603233,"version":"4.1.0"},"reference-count":71,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Bauerfeind AG","award":["BF18-OR-02"],"award-info":[{"award-number":["BF18-OR-02"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Patients with medial compartment knee osteoarthritis (OA) may benefit from wearing a valgus brace, but previous studies lacked consideration for brace wearing time, co-interventions and the brace users\u2019 perceptions. This mixed-method randomised controlled trial investigated the effectiveness of a valgus brace on knee pain and activity limitations alongside exploring user perceptions.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Materials and methods<\/jats:title>\n<jats:p>Participants randomised to the intervention group (n\u2009=\u200923) received regular care and a customisable valgus brace for 6 months while the participants randomised to the waitlist control group (n\u2009=\u200923) were allowed any regular care treatment except for a knee brace. Outcomes were evaluated with a multilevel linear regression analysis at baseline, 2 weeks, 3 months and 6 months. The primary outcome was knee pain intensity at 6 months measured by a 10-cm Visual Analogue Scale (VAS). Secondary outcomes included walking distance, generic health status, knee functioning and satisfaction with the brace. Qualitative interviews were conducted with a subsample of intervention group participants and transcripts were analysed using deductive thematic analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>After 6 months, only a statistically significant and clinically important difference of 2.13 cm (95% CI \u22123.57 to \u22120.69) on the VAS score for knee pain intensity after a walk test was found between the intervention and control groups. Although the qualitative findings echoed some participants\u2019 negative or mixed feelings about the brace, several participants perceived positive changes in pain, other body functions, during activities and had positive user experiences.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Using a valgus brace decreased knee pain intensity during walking activities. Although other outcomes showed limited effectiveness, the study\u2019s underpowered nature increased the risk of type II errors. Qualitative data highlighted positive user experiences, suggesting potential benefits beyond the measured quantitative outcomes.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0330157","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T17:51:07Z","timestamp":1757008267000},"page":"e0330157","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effectiveness and user experiences of a valgus brace in patients with knee osteoarthritis: A mixed-method randomised controlled trial"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1478-2619","authenticated-orcid":true,"given":"Lex D.","family":"de Jong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babette C.","family":"van der Zwaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthijs Y. 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Mine","year":"2017","journal-title":"Prosthet Orthot Int"},{"issue":"3","key":"pone.0330157.ref020","article-title":"Braces and orthoses for treating osteoarthritis of the knee","volume":"2015","author":"T Duivenvoorden","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"pone.0330157.ref021","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.joca.2020.10.011","article-title":"The compartmental distribution of knee osteoarthritis - a systematic review and meta-analysis","volume":"29","author":"JC Stoddart","year":"2021","journal-title":"Osteoarthritis Cartilage"},{"issue":"2","key":"pone.0330157.ref022","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1001\/jama.286.2.188","article-title":"The role of knee alignment in disease progression and functional decline in knee osteoarthritis","volume":"286","author":"L Sharma","year":"2001","journal-title":"JAMA"},{"issue":"10","key":"pone.0330157.ref023","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1002\/art.10530","article-title":"The influence of alignment on risk of knee osteoarthritis progression according to baseline stage of disease","volume":"46","author":"R Cerejo","year":"2002","journal-title":"Arthritis Rheum"},{"issue":"4","key":"pone.0330157.ref024","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/acr.22472","article-title":"Valgus bracing for knee osteoarthritis: a meta-analysis of randomized trials","volume":"67","author":"RF Moyer","year":"2015","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"1","key":"pone.0330157.ref025","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1186\/s12891-021-04513-0","article-title":"Effect of using knee valgus brace on pain and activity level over different time intervals among patients with medial knee OA: systematic review","volume":"22","author":"H 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The effect of lateral tibiofemoral separation and tibiofemoral length","volume":"274","author":"TW Dugdale","year":"1992","journal-title":"Clin Orthop Relat Res"},{"key":"pone.0330157.ref036","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclinepi.2018.05.007","article-title":"Minimum clinically important differences in chronic pain vary considerably by baseline pain and methodological factors: systematic review of empirical studies","volume":"101","author":"MF Olsen","year":"2018","journal-title":"J Clin Epidemiol"},{"issue":"13","key":"pone.0330157.ref037","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1080\/09638288.2022.2084776","article-title":"The Western Ontario and McMaster Universities osteoarthritis, lequesne algofunctional index, arthritis impact measurement scale-short form, and visual analogue scale in patients with knee osteoarthritis: responsiveness and minimal clinically important differences","volume":"45","author":"R Salehi","year":"2023","journal-title":"Disabil Rehabil"},{"issue":"5","key":"pone.0330157.ref038","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.bja.2021.01.021","article-title":"Minimal clinically important differences in randomised clinical trials on pain management after total hip and knee arthroplasty: a systematic review","volume":"126","author":"J Laigaard","year":"2021","journal-title":"Br J Anaesth"},{"issue":"2","key":"pone.0330157.ref039","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.joca.2014.11.018","article-title":"Biomechanical effects of valgus knee bracing: a systematic review and meta-analysis","volume":"23","author":"RF Moyer","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"issue":"8","key":"pone.0330157.ref040","doi-asserted-by":"crossref","first-page":"981","DOI":"10.3899\/jrheum.181194","article-title":"The OMERACT-OARSI core domain set for measurement in clinical trials of hip and\/or knee osteoarthritis","volume":"46","author":"TO Smith","year":"2019","journal-title":"J Rheumatol"},{"issue":"1","key":"pone.0330157.ref041","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1164\/ajrccm.166.1.at1102","article-title":"ATS statement: guidelines for the six-minute walk test","volume":"166","author":"ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"pone.0330157.ref042","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12891-018-2382-2","article-title":"\u201cMinimal clinically important difference\u201d estimates of 6 commonly-used performance tests in patients with chronic musculoskeletal pain completing a work-related multidisciplinary rehabilitation program","volume":"20","author":"C Benaim","year":"2019","journal-title":"BMC Musculoskelet Disord"},{"issue":"3","key":"pone.0330157.ref043","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/00005650-199603000-00003","article-title":"A 12-item short-form health survey: construction of scales and preliminary tests of reliability and validity","volume":"34","author":"J Ware","year":"1996","journal-title":"Med Care"},{"issue":"11","key":"pone.0330157.ref044","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/S0895-4356(98)00109-7","article-title":"Cross-validation of item selection and scoring for the SF-12 health survey in nine countries: results from the IQOLA project. International quality of life assessment","volume":"51","author":"B Gandek","year":"1998","journal-title":"J Clin Epidemiol"},{"issue":"1","key":"pone.0330157.ref045","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1136\/ard.2002.001784","article-title":"Satisfactory cross cultural equivalence of the Dutch WOMAC in patients with hip osteoarthritis waiting for arthroplasty","volume":"63","author":"LD Roorda","year":"2004","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"pone.0330157.ref046","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/1529-0131(200108)45:4<384::AID-ART352>3.0.CO;2-0","article-title":"Smallest detectable and minimal clinically important differences of rehabilitation intervention with their implications for required sample sizes using WOMAC and SF-36 quality of life measurement instruments in patients with osteoarthritis of the lower extremities","volume":"45","author":"F Angst","year":"2001","journal-title":"Arthritis Rheum"},{"issue":"1","key":"pone.0330157.ref047","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1037\/qup0000082","article-title":"Recommendations for designing and reviewing qualitative research in psychology: promoting methodological integrity","volume":"4","author":"HM Levitt","year":"2017","journal-title":"Qualitative Psychology"},{"issue":"1","key":"pone.0330157.ref048","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12874-018-0594-7","article-title":"Characterising and justifying sample size sufficiency in interview-based studies: systematic analysis of qualitative health research over a 15-year period","volume":"18","author":"K Vasileiou","year":"2018","journal-title":"BMC Med Res Methodol"},{"issue":"1","key":"pone.0330157.ref049","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/104973200129118183","article-title":"Determining sample size","volume":"10","author":"JM Morse","year":"2000","journal-title":"Qual Health Res"},{"issue":"1","key":"pone.0330157.ref050","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/10400435.1996.10132268","article-title":"Development of the quebec user evaluation of satisfaction with assistive technology (QUEST)","volume":"8","author":"L Demers","year":"1996","journal-title":"Assist Technol"},{"issue":"3","key":"pone.0330157.ref051","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/oti.95","article-title":"An international content validation of the Quebec user evaluation of satisfaction with assistive technology (QUEST)","volume":"6","author":"L Demers","year":"1999","journal-title":"Occupation Therapy Intl"},{"issue":"4","key":"pone.0330157.ref052","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1080\/17483107.2022.2161648","article-title":"A systematic review of the psychometric properties of Quebec user evaluation of satisfaction with assistive technology (QUEST)","volume":"19","author":"S Aledda","year":"2024","journal-title":"Disabil Rehabil Assist Technol"},{"issue":"2","key":"pone.0330157.ref053","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3233\/TAD-2000-13203","article-title":"IPPA, a user-centred approach to assess effectiveness of assistive technology provision","volume":"13","author":"R Wessels","year":"2001","journal-title":"TAD"},{"issue":"6","key":"pone.0330157.ref054","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1080\/00140139.2016.1227093","article-title":"Scoliosis brace design: influence of visual aesthetics on user acceptance and compliance","volume":"60","author":"D Law","year":"2017","journal-title":"Ergonomics"},{"key":"pone.0330157.ref055","unstructured":"Brooke J. 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