{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:00:30Z","timestamp":1759334430989,"version":"build-2065373602"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"PDRadiopharma Inc"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>This study aimed to determine the optimal measurement conditions for accurate standardized uptake value (SUV) analysis of iodine-123 metaiodobenzylguanidine (<jats:sup>123<\/jats:sup>I-MIBG) by examining the relationship between image convergence and quantitation. Single-photon emission computed tomography\/computed tomography images were acquired using JS-10 and National Electrical Manufacturers Association (NEMA) body phantoms, with acquisition time per view varied (10, 30, 50, and 100\u2009s\/view). Image reconstruction was performed using three-dimensional-ordered subset expectation maximization, adjusting the product of subset and iteration (SI product; 60, 120, 180) and Gaussian filter parameters (8, 10, 12\u2009mm). For the JS-10 phantom, we evaluated the dose linearity (DL), the recovery coefficient (RC) of individual rods, the scatter ratio (SR), and the coefficient of variation (CV). For the NEMA body phantom, we assessed the contrast-to-noise ratio (CNR) of the 17-mm-diameter hot sphere. We also evaluated the maximum and mean SUVs for all its hot spheres, and their relative standard error (RSE), using SUVs obtained at 100\u2009s\/view as reference. In the JS-10 phantom, the DL remained stable under all conditions. The RC decreased when the Gaussian filter was large and the SI product was small. A\u00a0trade-off\u00a0between the CV and the SR emerged, depending on the acquisition time and the SI product; optimal results were observed at 50\u2009\u2212\u2009100\u2009s\/view and an SI product of 120\u2009\u2212\u2009180. In the NEMA body phantom, contrast improved with acquisition times of \u226530\u2009s\/view, and the CNR increased as noise declined with longer acquisition times. At \u226550\u2009s\/view, variation in the maximum and mean SUVs decreased, with the RSE remaining below 5%. In conclusion, accurate SUV measurement with \u00b9\u00b2\u00b3I-MIBG requires an acquisition time of \u226550\u2009s\/view, an SI product of approximately 120, and a Gaussian filter of 10\u2009\u2212\u200912\u2009mm. These findings provide a foundation for future studies comparing this method with the heart-to-mediastinum ratio, supporting its clinical application.<\/jats:p>","DOI":"10.1371\/journal.pone.0330655","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T17:26:17Z","timestamp":1759253177000},"page":"e0330655","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimization of acquisition time and reconstruction parameters for quantitative single-photon emission computed tomography\/computed tomography using iodine-123 metaiodobenzylguanidine"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2980-5366","authenticated-orcid":true,"given":"Masakazu","family":"Tsujimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenta","family":"Nogami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6621-4325","authenticated-orcid":true,"given":"Masayoshi","family":"Sarai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"issue":"5","key":"pone.0330655.ref001","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/0735-1097(88)92608-3","article-title":"Iodine-123 meta-iodobenzylguanidine scintigraphy: a noninvasive method to demonstrate myocardial adrenergic nervous system disintegrity in patients with idiopathic dilated cardiomyopathy","volume":"12","author":"J Schofer","year":"1988","journal-title":"J Am Coll Cardiol"},{"key":"pone.0330655.ref002","volume-title":"Nuclear medicine notebook","author":"A Kubo","year":"2019","edition":"6"},{"key":"pone.0330655.ref003","article-title":"123I-MIBG SPECT for evaluation of patients with heart failure","author":"AC Dimitriu-Leen","year":"2015","journal-title":"J Nucl Med"},{"issue":"3","key":"pone.0330655.ref004","first-page":"371","article-title":"Loss of 123I-MIBG uptake by the heart in Parkinson\u2019s disease: assessment of cardiac sympathetic denervation and diagnostic value","volume":"40","author":"A Satoh","year":"1999","journal-title":"J Nucl Med"},{"issue":"1","key":"pone.0330655.ref005","first-page":"39","article-title":"Human papillomavirus detection to screen for cervical cancer","volume":"284","author":"M Moselhi","year":"2000","journal-title":"JAMA"},{"key":"pone.0330655.ref006","first-page":"471","article-title":"Prognostic value of cardiac metaiodobenzylguanidine imaging in patients with heart failure","volume":"33","author":"P Merlet","year":"1992","journal-title":"J Nucl Med"},{"issue":"2","key":"pone.0330655.ref007","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1161\/CIRCIMAGING.108.782433","article-title":"123 I-mIBG scintigraphy to predict inducibility of ventricular arrhythmias on cardiac electrophysiology testing: a prospective multicenter pilot study","volume":"1","author":"JJ Bax","year":"2008","journal-title":"Circ Cardiovasc Imaging"},{"issue":"4","key":"pone.0330655.ref008","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1007\/s12350-020-02501-w","article-title":"The prognostic value of 123I-mIBG SPECT cardiac imaging in heart failure patients: a systematic review","volume":"29","author":"M Pontico","year":"2022","journal-title":"J Nucl Cardiol"},{"issue":"1","key":"pone.0330655.ref009","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12880-021-00569-5","article-title":"Standardized uptake values of 99mTc-MDP in normal vertebrae assessed using quantitative SPECT\/CT for differentiation diagnosis of benign and malignant bone lesions","volume":"21","author":"N Qi","year":"2021","journal-title":"BMC Med Imaging"},{"issue":"1","key":"pone.0330655.ref010","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s40658-019-0267-6","article-title":"Analysis of quantitative [I-123] mIBG SPECT\/CT in a phantom and in patients with neuroblastoma","volume":"6","author":"SL Brady","year":"2019","journal-title":"EJNMMI Phys"},{"issue":"1","key":"pone.0330655.ref011","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s12149-013-0785-6","article-title":"Optimization of iterative reconstruction parameters with attenuation correction, scatter correction and resolution recovery in myocardial perfusion SPECT\/CT","volume":"28","author":"K Okuda","year":"2014","journal-title":"Ann Nucl Med"},{"issue":"1","key":"pone.0330655.ref012","doi-asserted-by":"crossref","first-page":"117","DOI":"10.17996\/anc.17-00015","article-title":"Qualitative and quantitative assessments of cardiac sarcoidosis using 18F-FDG PET","volume":"3","author":"O Manabe","year":"2017","journal-title":"Annals of Nuclear Cardiology"},{"issue":"5","key":"pone.0330655.ref013","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1097\/MNM.0000000000001680","article-title":"Volume-based 18 F-FDG PET analysis of cardiac sarcoidosis using the descending aorta as a reference tissue","volume":"44","author":"M Tsujimoto","year":"2023","journal-title":"Nucl Med Commun"},{"issue":"7","key":"pone.0330655.ref014","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1097\/MNM.0000000000000854","article-title":"Fluctuation of quantitative values on acquisition time and the reconstruction conditions in 99mTc-SPECT","volume":"39","author":"M Tsujimoto","year":"2018","journal-title":"Nucl Med Commun"},{"key":"pone.0330655.ref015","first-page":"77","article-title":"Fundamental study on collection and reconstruction conditions in 111 In-SPECT","volume":"34","author":"K Kawakami","year":"2016","journal-title":"Pharm Med"},{"issue":"8","key":"pone.0330655.ref016","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.2967\/jnumed.112.105155","article-title":"SNMMI\/ASNC\/SCCT guideline for cardiac SPECT\/CT and PET\/CT 1.0","volume":"54","author":"S Dorbala","year":"2013","journal-title":"J Nucl Med"},{"issue":"12","key":"pone.0330655.ref017","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1007\/s00259-012-2215-8","article-title":"EANM 2012 guidelines for radionuclide imaging of phaeochromocytoma and paraganglioma","volume":"39","author":"D Ta\u00efeb","year":"2012","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"12","key":"pone.0330655.ref018","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.6009\/jjrt.2014_JSRT_70.12.1420","article-title":"Validation of an optimal analysis method and reproducibility to calculate the heart-to-mediastinum ratio and washout rate in the iodine-123-labeled metaiodobenzylguanidine myocardial scintigraphy","volume":"70","author":"D Hasegawa","year":"2014","journal-title":"Nihon Hoshasen Gijutsu Gakkai Zasshi"},{"issue":"2","key":"pone.0330655.ref019","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s13246-021-00983-7","article-title":"Two-versus three-dimensional regions of interest for quantifying SPECT-CT images","volume":"44","author":"M Tsujimoto","year":"2021","journal-title":"Phys Eng Sci Med"},{"issue":"1","key":"pone.0330655.ref020","doi-asserted-by":"crossref","first-page":"25","DOI":"10.6009\/jjrt.2023-1235","article-title":"Three-dimensional quantitative evaluation method in 123I-MIBG Myocardial SPECT-CT","volume":"79","author":"Y Yasumoto","year":"2023","journal-title":"Nihon Hoshasen Gijutsu Gakkai Zasshi"},{"issue":"4","key":"pone.0330655.ref021","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s11604-022-01365-z","article-title":"Application of 123I-MIBG myocardial maximum standardized uptake value to characterize cardiac function in patients with pheochromocytoma: comparison with echocardiography","volume":"41","author":"M Nakajo","year":"2023","journal-title":"Jpn J Radiol"},{"issue":"11","key":"pone.0330655.ref022","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.6009\/jjrt.2015_JSRT_71.11.1070","article-title":"Evaluation of resolution correction in single photon emission computed tomography reconstruction method using a body phantom: study of three different models","volume":"71","author":"Y Maeda","year":"2015","journal-title":"Nihon Hoshasen Gijutsu Gakkai Zasshi"},{"issue":"6","key":"pone.0330655.ref023","doi-asserted-by":"crossref","first-page":"686","DOI":"10.6009\/jjrt.2012_JSRT_68.6.686","article-title":"Evaluation of commercial resolution recovery techniques in four state-of-the-art single photon emission computed tomography systems using a digital phantom model","volume":"68","author":"H Onishi","year":"2012","journal-title":"Nihon Hoshasen Gijutsu Gakkai Zasshi"},{"issue":"7","key":"pone.0330655.ref024","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/BF00285592","article-title":"Scatter correction in scintigraphy: the state of the art","volume":"21","author":"I Buvat","year":"1994","journal-title":"Eur J Nucl Med"},{"issue":"7","key":"pone.0330655.ref025","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1007\/s12149-015-0987-1","article-title":"Optimization of iterative reconstruction parameters with 3-dimensional resolution recovery, scatter and attenuation correction in \u00b9\u00b2\u00b3I-FP-CIT SPECT","volume":"29","author":"N Matsutomo","year":"2015","journal-title":"Ann Nucl Med"},{"issue":"9","key":"pone.0330655.ref026","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1007\/s00259-010-1491-4","article-title":"Proposal for standardization of 123I-metaiodobenzylguanidine (MIBG) cardiac sympathetic imaging by the EANM Cardiovascular Committee and the European Council of Nuclear Cardiology","volume":"37","author":"A Flotats","year":"2010","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"pone.0330655.ref027","first-page":"129","article-title":"Myocardial imaging in man with I-123 meta-iodobenzylguanidine","volume":"22","author":"RC Kline","year":"1981","journal-title":"J Nucl Med"},{"key":"pone.0330655.ref028","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/BF00812368","article-title":"Whole-body distribution of iodine 123 metaiodobenzylguanidine in hypertrophic cardiomyopathy: significance of its washout from the heart","volume":"17","author":"J Taki","year":"1990","journal-title":"Eur J Nucl Med"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0330655","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T17:26:22Z","timestamp":1759253182000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0330655"}},"subtitle":[],"editor":[{"given":"Lorenzo","family":"Faggioni","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":28,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0330655","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2025,9,30]]}}}