{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:06:56Z","timestamp":1756512416439,"version":"3.44.0"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Start-up Fund Project of Affiliated Huaian No.1 People's Hospital of Nanjing Medical University","award":["GQ202313"],"award-info":[{"award-number":["GQ202313"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Vitamin D is a fat-soluble secosteroid that plays essential roles in calcium homeostasis, bone metabolism, and numerous other physiological processes. Vitamin D deficiency has been associated with increased risk of various diseases and mortality. However, population-based studies examining the relationship between vitamin D and mortality across different age groups remain limited.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>To investigate the correlation between 25-hydroxyvitamin D [25(OH)D] levels, vitamin D status, and mortality in a cohort of 47,478 individuals aged 18\u201385 years.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Higher 25(OH)D levels were associated with lower mortality risk. Compared to the vitamin D deficiency group, the Hazard ratios (HR) for all-cause mortality were 0.71 (95%CI: 0.66\u20130.76) in the insufficiency group and 0.64 (95%CI: 0.58\u20130.70) in the sufficiency group. The association varied by age: strongest in adults aged 40\u201359 years (HR: 0.74, 95% CI: 0.65\u20130.85), significant in those \u226560 years (HR: 0.86, 95% CI: 0.82\u20130.90), but non-significant in those aged 18\u201339 years. The RCS analysis revealed a non-linear relationship between 25(OH)D and mortality, with significant risk reduction observed between 59.25\u2013261.45 nmol\/L for the overall population. The optimal 25(OH)D levels (lowest HR) varied by subgroups: 96.81 nmol\/L for the overall population, 102.9 nmol\/L for females, 67 nmol\/L for ages 40\u201359, and 104.23 nmol\/L for ages \u226560 years, while no significant association was found in ages 18\u201339 years.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Our findings suggest that Vitamin D are associated with mortality among the whole population. Individuals aged 40\u201359 may derive potential benefits from vitamin D supplementation.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0330959","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T17:36:16Z","timestamp":1756488976000},"page":"e0330959","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Age-specific benefits of Vitamin D and its association with 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