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These derivatives exhibit enhanced stability and potent anticancer and anti-inflammatory activities. The material named medi-MOF-2 was constructed using biocompatible zinc ions and characterized for its structural and functional properties. It exhibited permanent porosity with a Brunauer-Emmett-Teller (BET) surface area of 264 m<jats:sup>2<\/jats:sup>\/g. Pore size distribution analysis revealed a micropore volume of 0.146\u2009cm<jats:sup>3<\/jats:sup>\/g and an average pore diameter of 11.92 \u00c5. Medi-MOF-2 demonstrated a remarkable ibuprofen loading capacity of 160\u2009mg\/g, enabling the simultaneous release of both curcumin derivatives and ibuprofen. 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