{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T15:20:39Z","timestamp":1774365639898,"version":"3.50.1"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["CS-2018-18-ST2-005"],"award-info":[{"award-number":["CS-2018-18-ST2-005"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","award":["MR\/T019050\/1"],"award-info":[{"award-number":["MR\/T019050\/1"]}],"id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["311252\/Z\/24\/Z"],"award-info":[{"award-number":["311252\/Z\/24\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Rubin Foundation Charitable Trust"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Anterior segment optical coherence tomography (AS-OCT) is emerging as a valuable diagnostic, monitoring and predictive tool. Clinical utility has been suggested for ophthalmic disorders such as glaucoma, corneal disease, cataract and uveitis, which taken together comprise the majority of the blinding conditions affecting working age individuals globally. anterior segment is an obstacle to reproducibility and interoperability. To provide this guidance, we aim to extend the existing Advised Protocol for OCT Study Terminology and Elements (APOSTEL) guidelines, to ensure applicability to AS-OCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In line with EQUATOR Network guidance for the development of reporting guidelines, APOSTEL-AS will be developed through a staged consensus process involving literature review and Delphi consensus across an international multi-disciplinary stakeholder group, overseen by a multi-disciplinary multi-national Steering Committee. The systematic scoping review will be used to generate candidate items, support the development of a consensus nomenclature for AS-OCT representation of ocular structure, and to form Delphi group membership. Delphi methodology, used to consider items for inclusion, rewording or exclusion, will be undertaken in line with ACCORD (ACcurate COnsensus Reporting Document) guidance, with at least two rounds of Delphi survey, inclusion consensus threshold set at 80%, and steering committee reviews between rounds. The resultant APOSTEL-AS guideline will undergo piloting before dissemination of the final version.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The APOSTEL-AS checklist, with minimum and recommended items to be reported about study methods, should provide timely support for researchers to ensure future standardisation, interoperability and reproducibility of reported work, hastening implementation and the translation of knowledge into clinically beneficial action.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0331272","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T18:28:26Z","timestamp":1763576906000},"page":"e0331272","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Development of the advised protocol for OCT study terminology and elements anterior segment OCT extension reporting guidelines (APOSTEL-AS): Study protocol"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8933-5864","authenticated-orcid":true,"given":"Ameenat Lola","family":"Solebo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Ang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Bellchambers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2088-8310","authenticated-orcid":true,"given":"Colin J.","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alastair K.","family":"Denniston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1596-2259","authenticated-orcid":true,"given":"Laura E.","family":"Downie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5193-0467","authenticated-orcid":true,"given":"Thomas","family":"Evans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2871-7764","authenticated-orcid":true,"given":"Alexander S.","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6913-6107","authenticated-orcid":true,"given":"Scott","family":"Hau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex S.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9239-745X","authenticated-orcid":true,"given":"Pearse A.","family":"Keane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jodhbir S.","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Ometto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0344-9749","authenticated-orcid":true,"given":"Axel","family":"Petzold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmund","family":"Tsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara S.","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"issue":"3","key":"pone.0331272.ref001","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/APO.0000000000000468","article-title":"Optical Coherence Tomography Classification Systems for Diabetic Macular Edema and Their Associations With Visual Outcome and Treatment Responses - An Updated Review","volume":"11","author":"VWK Hui","year":"2022","journal-title":"Asia Pac J Ophthalmol (Phila)"},{"key":"pone.0331272.ref002","doi-asserted-by":"crossref","first-page":"101052","DOI":"10.1016\/j.preteyeres.2022.101052","article-title":"Detecting glaucoma with only OCT: Implications for the clinic, research, screening, and AI development","volume":"90","author":"DC Hood","year":"2022","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"pone.0331272.ref003","article-title":"Optical coherence tomography (OCT) for detection of macular oedema in patients with diabetic retinopathy","volume":"1","author":"G Virgili","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"pone.0331272.ref004","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1167\/tvst.9.2.6","article-title":"Insights into Systemic Disease through Retinal Imaging-Based Oculomics","volume":"9","author":"SK Wagner","year":"2020","journal-title":"Transl Vis Sci Technol"},{"issue":"1","key":"pone.0331272.ref005","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/nyas.15060","article-title":"Combining retinal structural and vascular measurements improves discriminative power for multiple sclerosis patients","volume":"1529","author":"M Bostan","year":"2023","journal-title":"Ann N Y Acad Sci"},{"key":"pone.0331272.ref006","doi-asserted-by":"crossref","first-page":"1232941","DOI":"10.3389\/fnagi.2023.1232941","article-title":"The association between retina thinning and hippocampal atrophy in Alzheimer\u2019s disease and mild cognitive impairment: a meta-analysis and systematic review","volume":"15","author":"S Chen","year":"2023","journal-title":"Front Aging Neurosci"},{"issue":"16","key":"pone.0331272.ref007","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000207727","article-title":"Retinal Optical Coherence Tomography Features Associated With Incident and Prevalent Parkinson Disease","volume":"101","author":"SK Wagner","year":"2023","journal-title":"Neurology"},{"issue":"2","key":"pone.0331272.ref008","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1212\/WNL.0000000000012125","article-title":"APOSTEL 2.0 Recommendations for Reporting Quantitative Optical Coherence Tomography Studies","volume":"97","author":"A Aytulun","year":"2021","journal-title":"Neurology"},{"issue":"24","key":"pone.0331272.ref009","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1212\/WNL.0000000000002774","article-title":"The APOSTEL recommendations for reporting quantitative optical coherence tomography studies","volume":"86","author":"A Cruz-Herranz","year":"2016","journal-title":"Neurology"},{"issue":"6","key":"pone.0331272.ref010","article-title":"Intraocular robotic interventional surgical system (IRISS): Semi-automated OCT-guided cataract removal","volume":"14","author":"C-W Chen","year":"2018","journal-title":"Int J Med Robot"},{"issue":"3","key":"pone.0331272.ref011","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.survophthal.2013.06.005","article-title":"Application of anterior segment optical coherence tomography in glaucoma","volume":"59","author":"R Sharma","year":"2014","journal-title":"Surv Ophthalmol"},{"issue":"2","key":"pone.0331272.ref012","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1364\/BOE.10.000622","article-title":"CorneaNet: fast segmentation of cornea OCT scans of healthy and keratoconic eyes using deep learning","volume":"10","author":"VA Dos Santos","year":"2019","journal-title":"Biomed Opt Express"},{"issue":"7","key":"pone.0331272.ref013","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1136\/bjophthalmol-2021-320448","article-title":"Quantitative and qualitative assessment of anterior segment optical coherence tomography capture of disease state in childhood anterior uveitis","volume":"107","author":"K Etherton","year":"2023","journal-title":"Br J Ophthalmol"},{"key":"pone.0331272.ref014","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ajo.2022.05.012","article-title":"Quantification of Anterior Chamber Cells in Children With Uveitis Using Anterior Segment Optical Coherence Tomography","volume":"241","author":"E Tsui","year":"2022","journal-title":"Am J Ophthalmol"},{"issue":"6","key":"pone.0331272.ref015","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1001\/jamaophthalmol.2023.0937","article-title":"Biometric Risk Factors for Angle Closure Progression After Laser Peripheral Iridotomy","volume":"141","author":"YK Bao","year":"2023","journal-title":"JAMA Ophthalmol"},{"issue":"3","key":"pone.0331272.ref016","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ophtha.2021.10.003","article-title":"Ocular Biometric Risk Factors for Progression of Primary Angle Closure Disease","volume":"129","author":"BY Xu","year":"2022","journal-title":"Ophthalmology"},{"issue":"12","key":"pone.0331272.ref017","doi-asserted-by":"crossref","DOI":"10.1016\/S2214-109X(17)30393-5","article-title":"Global causes of blindness and distance vision impairment 1990-2020: a systematic review and meta-analysis","volume":"5","author":"SR Flaxman","year":"2017","journal-title":"Lancet Glob Health"},{"issue":"10","key":"pone.0331272.ref018","article-title":"Age- and refraction-related changes in anterior segment anatomical structures measured by swept-source anterior segment OCT","volume":"15","author":"X Xie","year":"2020","journal-title":"PLoS One"},{"issue":"1","key":"pone.0331272.ref019","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s41073-022-00122-0","article-title":"ACCORD guideline for reporting consensus-based methods in biomedical research and clinical practice: a study protocol","volume":"7","author":"WT Gattrell","year":"2022","journal-title":"Res Integr Peer Rev"},{"issue":"1","key":"pone.0331272.ref020","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1136\/bjophthalmol-2018-313789","article-title":"Areas of agreement in the management of childhood non-infectious chronic anterior uveitis in the UK","volume":"104","author":"AL Solebo","year":"2020","journal-title":"Br J Ophthalmol"},{"key":"pone.0331272.ref021","doi-asserted-by":"crossref","first-page":"881398","DOI":"10.3389\/fped.2022.881398","article-title":"Development of a Nationally Agreed Core Clinical Dataset for Childhood Onset Uveitis","volume":"10","author":"AL Solebo","year":"2022","journal-title":"Front Pediatr"},{"issue":"4","key":"pone.0331272.ref022","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0034823","article-title":"The OSCAR-IB consensus criteria for retinal OCT quality assessment","volume":"7","author":"P Tewarie","year":"2012","journal-title":"PLoS One"},{"issue":"7","key":"pone.0331272.ref023","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1002\/acn3.51320","article-title":"Artificial intelligence extension of the OSCAR-IB criteria","volume":"8","author":"A Petzold","year":"2021","journal-title":"Ann Clin Transl Neurol"},{"issue":"5","key":"pone.0331272.ref024","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1136\/bjo-2022-322328","article-title":"Automated expert-level scleral spur detection and quantitative biometric analysis on the ANTERION anterior segment OCT system","volume":"108","author":"K Bolo","year":"2024","journal-title":"Br J Ophthalmol"},{"issue":"2","key":"pone.0331272.ref025","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1167\/tvst.9.2.18","article-title":"Deep Neural Network for Scleral Spur Detection in Anterior Segment OCT Images: The Chinese American Eye Study","volume":"9","author":"BY Xu","year":"2020","journal-title":"Transl Vis Sci Technol"},{"issue":"2","key":"pone.0331272.ref026","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/art.41530","article-title":"Imaging\u2010Based Uveitis Surveillance in Juvenile Idiopathic Arthritis: Feasibility, Acceptability, and Diagnostic Performance","volume":"73","author":"S Akbarali","year":"2020","journal-title":"Arthritis & Rheumatology"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0331272","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T18:28:33Z","timestamp":1763576913000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0331272"}},"subtitle":[],"editor":[{"given":"Kumar","family":"Saurabh","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,11,19]]},"references-count":26,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0331272","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,19]]}}}