{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:04:33Z","timestamp":1789146273285,"version":"build-2803163510"},"reference-count":15,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>Current guidelines suggest surgical decompression for ischemic cerebellar stroke in case of significant mass effect. Recent research has aimed to identify a possible threshold for mass effect. However, a computer-assisted volumetry in acute setting is time consuming and impracticable, wherefore the aim of this study was to assess the accuracy and clinical applicability of the ABC\/2 method in case of ischemic cerebellar stroke.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Materials and methods<\/jats:title>\n<jats:p>Imaging data of 125 patients, including preoperative CT or MRI scans were used for volumetric analysis. The ABC\/2 formula using scans in axial and coronal planes. BrainLab\u00ae Elements software was used for computer assisted volumetry by defining the region of interest allowing automated volumetric calculation. Measurements were conducted independently by blinded clinicians. Pearson correlation and Bland-Altmann test were used for statistical analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Among the 125 cerebellar infarctions analyzed, there was no statistical difference of mean infarct volume measurement between the ABC\/2 formula and computer-assisted volumetry (16.6mL vs. 15.91mL; range 0.8-67.7mL; p\u2009=\u20090.76). The Spearman correlation test indicated a strong correlation between the two methods (r\u2009=\u20090.985, 95% CI: 0.979\u20130.990, p\u2009&lt;\u20090.0001). Discrepancies were most notable in smaller infarction volumes (&lt;10\u2009mL), prompting a subgroup analysis. For infarct volume less than 10mL, the ratio of volumetric differences ranged from 47% to 60%, with absolute volume differences from \u22123\u20133\u2009mL whereas the ratio ranged from \u221220% to 29%, with absolute volume differences from \u22126\u20138\u2009mL in cases with infarct volume greater equal 10mL.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>ABC\/2 formula shows a good correlation with computer-assisted volumetry. Consequently, it could serve as a fast and practical tool for estimating cerebellar infarct volume and aiding decision-making in clinical practice. However, the limitations and variability of the ABC\/2 method, particularly for smaller infarcts, must be considered.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0331296","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T17:32:28Z","timestamp":1756229548000},"page":"e0331296","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of the ABC\/2 formula with computer-assisted volumetry of ischemic cerebellar stroke"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9357-3312","authenticated-orcid":true,"given":"Milos","family":"Arsenovic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4447-6919","authenticated-orcid":true,"given":"Artem","family":"Rafaelian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Dubinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Cantr\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bedjan","family":"Behmanesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0795-2648","authenticated-orcid":true,"given":"Svorad","family":"Trnovec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2591-2829","authenticated-orcid":true,"given":"Thomas M.","family":"Freiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3918-8066","authenticated-orcid":true,"given":"Marc-Andr\u00e9","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Wittstock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Gessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6585-5403","authenticated-orcid":true,"given":"Sae-Yeon","family":"Won","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"issue":"2","key":"pone.0331296.ref001","doi-asserted-by":"crossref","first-page":"XC","DOI":"10.1177\/23969873211014112","article-title":"European Stroke Organisation (ESO) guidelines on the management of space-occupying brain infarction","volume":"6","author":"HB van der Worp","year":"2021","journal-title":"Eur Stroke J"},{"issue":"12","key":"pone.0331296.ref002","doi-asserted-by":"crossref","DOI":"10.1161\/STR.0000000000000211","article-title":"Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association\/American Stroke Association","volume":"50","author":"WJ Powers","year":"2019","journal-title":"Stroke"},{"issue":"4","key":"pone.0331296.ref003","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1001\/jamaneurol.2023.5773","article-title":"Functional Outcomes in Conservatively vs Surgically Treated Cerebellar Infarcts","volume":"81","author":"SY Won","year":"2024","journal-title":"JAMA Neurology"},{"issue":"8","key":"pone.0331296.ref004","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1161\/01.STR.27.8.1304","article-title":"The ABCs of measuring intracerebral hemorrhage volumes","volume":"27","author":"RU Kothari","year":"1996","journal-title":"Stroke"},{"issue":"6","key":"pone.0331296.ref005","article-title":"Excellent accuracy of ABC\/2 volume formula compared to computer-assisted volumetric analysis of subdural hematomas","volume":"13","author":"S-Y Won","year":"2018","journal-title":"PLoS One"},{"issue":"6","key":"pone.0331296.ref006","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1097\/MAO.0000000000001423","article-title":"Calculating the Tumor Volumes in Vestibular Schwannomas: Are the ABC\/2 and Volumetric Methods Comparable?","volume":"38","author":"G Bathla","year":"2017","journal-title":"Otol Neurotol"},{"issue":"20","key":"pone.0331296.ref007","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.032195","article-title":"The ABCs of Subarachnoid Hemorrhage Blood Volume Measurement: A Simplified Quantitative Method Predicts Outcomes and Delayed Cerebral Ischemia","volume":"13","author":"F F\u00f6ttinger","year":"2024","journal-title":"J Am Heart Assoc"},{"key":"pone.0331296.ref008","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1089\/neu.2024.0248","article-title":"Volumetric assessment of traumatic intracranial hematomas: Is ABC\/2 reliable?","volume":"41","author":"A Fletcher-Sandersj\u00f6\u00f6","year":"2024","journal-title":"Journal of Neurotrauma"},{"issue":"1","key":"pone.0331296.ref009","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s41016-022-00287-z","article-title":"ABC\/2 formula for \u201cbedside\u201d postoperative pneumocephalus volume measurement","volume":"8","author":"DYC Chan","year":"2022","journal-title":"Chin Neurosurg J"},{"key":"pone.0331296.ref010","article-title":"Reliability of ABC\/2 volumetric estimation in spontaneous intracerebral hemorrhage for hematoma expansion prediction scores","author":"S Tanioka","year":"2024","journal-title":"Eur Stroke J"},{"issue":"3","key":"pone.0331296.ref011","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1159\/000504531","article-title":"Comparison of ABC Methods with Computerized Estimates of Intracerebral Hemorrhage Volume: The INTERACT2 Study","volume":"9","author":"C Delcourt","year":"2019","journal-title":"Cerebrovasc Dis Extra"},{"issue":"8","key":"pone.0331296.ref012","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1590\/0004-282X20130084","article-title":"Hematoma volumes of spontaneous intracerebral hemorrhage: the ellipse (ABC\/2) method yielded volumes smaller than those measured using the planimetric method","volume":"71","author":"AK Maeda","year":"2013","journal-title":"Arq Neuropsiquiatr"},{"key":"pone.0331296.ref013","article-title":"Predictors of malignant swelling in space-occupying cerebellar infarction","author":"E Baki","year":"2024","journal-title":"Stroke Vasc Neurol"},{"issue":"4","key":"pone.0331296.ref014","article-title":"Artificial intelligence\u2013based rapid brain volumetry substantially improves differential diagnosis in dementia","volume":"16","author":"J Rudolph","year":"2024","journal-title":"Alzheimer\u2019s and Dementia: Diagnosis, Assessment and Disease Monitoring"},{"issue":"6","key":"pone.0331296.ref015","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcad271","article-title":"Artificial-intelligence-based MRI brain volumetry in patients with essential tremor and tremor-dominant Parkinson\u2019s disease","volume":"5","author":"V Purrer","year":"2023","journal-title":"Brain Commun"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0331296","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T17:32:32Z","timestamp":1756229552000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0331296"}},"subtitle":[],"editor":[{"given":"Atakan","family":"Orscelik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,8,26]]},"references-count":15,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0331296","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,26]]}}}