{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:26:37Z","timestamp":1792020397996,"version":"4.4.0"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the government of Upper Austria via the FFG","award":["FO999895610"],"award-info":[{"award-number":["FO999895610"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>The Anterior Communicating Artery complex (AComA) is one of the most common intracranial aneurysms locations. Accurate rupture risk assessment in patients with cerebral aneurysms is essential for optimizing treatment decisions. Computational fluid dynamics has significantly advanced insight into aneurysmal hemodynamics. Many studies concentrate predominantly on blood flow patterns, frequently neglecting the biomechanical properties of the aneurysm wall. Fluid-structure interaction analysis combines hemodynamic behavior with wall mechanics, potentially facilitating a more thorough evaluation of rupture risk assessment.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>In this study, we employed advanced techniques to investigate several single and composite parameters to predict the rupture risk of AComA aneurysms in a cohort of 150 patients treated at the Kepler University Hospital in Linz, Austria. For this reason, clinical, morphological, hemodynamic, and structural mechanical parameters were assessed.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>A subsequent workflow analysis, consisting of comparative analysis, collinearity analysis, predictive modeling, composite parameter, performance evaluation, and internal threshold validation, revealed the Gaussian curvature GLN (AUC\u2009=\u20090.91) with a sensitivity of 0.93 and specificity of 0.83 as a best-performing single parameter for aneurysm rupture prediction. Composite parameters like WGD (combination of wall shear stress, Gaussian curvature, and wall displacement) achieved an AUC of 0.89, and WG (combination of wall shear stress and Gaussian curvature) an AUC of 0.88. An internal validation with 25 independent ruptured aneurysms was performed, and the previous results were confirmed with very high sensitivity values of 0.92 for GLN.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Our findings indicate that the investigated morphological, hemodynamic, and structural, mechanical parameters could provide a potential tool for evaluating rupture risk for AComA aneurysms. The single morphological parameter GLN offers, followed by composite parameters WGD and WG, excellent prediction power for the aneurysm rupture state, as confirmed by internal validation. Further studies are warranted to evaluate the prospective clinical application of these parameters.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0331297","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T17:28:26Z","timestamp":1756834106000},"page":"e0331297","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Rupture risk assessment for AComA aneurysms with morphological, hemodynamic and structural mechanical analysis"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0729-0683","authenticated-orcid":true,"given":"Jozsef","family":"Nagy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6929-3142","authenticated-orcid":true,"given":"Nico","family":"Stroh-Holly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6143-3024","authenticated-orcid":true,"given":"Wolfgang","family":"Fenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9838-3641","authenticated-orcid":true,"given":"Stefan","family":"Thumfart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Maier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoltan","family":"Major","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Stefanits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Gollwitzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Oberndorfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Mazanec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1620-1002","authenticated-orcid":true,"given":"Michael","family":"Giretzlehner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sonnberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6464-8856","authenticated-orcid":true,"given":"Philip","family":"Rauch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Gruber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Gmeiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"issue":"2","key":"pone.0331297.ref001","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1227\/01.NEU.0000316847.64140.81","article-title":"Morphology parameters for intracranial aneurysm rupture risk assessment","volume":"63","author":"S Dhar","year":"2008","journal-title":"Neurosurgery"},{"key":"pone.0331297.ref002","volume-title":"Microneurosurgery: clinical considerations, surgery of the intracranial aneurysms and results. 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