{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:08:44Z","timestamp":1791166124226,"version":"4.1.0"},"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The hemoglobin\/red blood cell distribution width (Hb\/RDW) ratio has emerged as a potential biomarker for acute kidney injury (AKI), particularly in patients with cardiovascular conditions. This study investigated the relationship between Hb\/RDW ratio and AKI incidence in critically ill patients diagnosed with sepsis and heart failure (HF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study was conducted with 119 critically ill patients with sepsis and 83 patients with HF, analyzed according to the presence or absence of kidney injury. Multivariable logistic regression identified independent predictors of AKI. Outcomes between higher and lower Hb\/RDW groups were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients who developed AKI showed higher C-reactive protein levels, elevated RDW (15.7\u2009\u00b1\u20092.2 vs. 14.9\u2009\u00b1\u20091.8; p\u2009=\u20090.01), and higher SAPS 3 scores, along with markedly lower Hb concentrations and Hb\/RDW ratios (75.1\u2009\u00b1\u20091.6 vs. 85.5\u2009\u00b1\u20091.9; p\u2009&lt;\u20090.001). In multivariable analysis, serum urea (OR 1.016; 95% CI 1.005\u20131.027 per mg\/dL), SAPS 3, and Hb\/RDW ratio (OR 0.977; 95% CI 0.959\u20130.996) were independently associated with AKI. Patients with a lower Hb\/RDW ratio had higher frequencies of AKI, kidney-replacement therapy, red-cell transfusion, and mortality. During a 7-year follow-up, progression to dialysis-dependent stage V chronic kidney disease (CKD-V) occurred in 10.8% of HF patients and 2.5% of sepsis patients, indicating that a lower Hb\/RDW ratio was also associated with worse long-term renal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The Hb\/RDW ratio is independently associated with AKI and may also reflect long-term kidney prognosis, representing a cost-effective and readily available ICU marker to identify patients at risk for both acute and chronic renal deterioration in sepsis or HF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0331332","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T18:41:54Z","timestamp":1772217714000},"page":"e0331332","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association between hemoglobin\/red blood cell distribution width ratio and acute kidney injury in sepsis and heart failure patients"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6396-446X","authenticated-orcid":true,"given":"Petherson","family":"Mendon\u00e7a dos Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabele","family":"Pardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Carolina","family":"Borges Pereira de Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Santana de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Gabas Miglioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Mota Busnardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Prieto Siqueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Harsanyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreia","family":"Pardini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8290-8554","authenticated-orcid":true,"given":"Bruno","family":"Bravim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9423-0329","authenticated-orcid":true,"given":"Anna","family":"Carolina de Rizzo Cantoni Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirliane","family":"de Sousa Rodrigues Lacerda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvve","family":"Priscila Gatto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Andrade Pinheiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rayane","family":"Alves Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateus","family":"Am\u00e9rico Galv\u00e3o Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3700-3654","authenticated-orcid":true,"given":"Jo\u00e3o","family":"Paulo Fonseca da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2245-5765","authenticated-orcid":true,"given":"Jo\u00e3o","family":"Marcos Santos da Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remo","family":"Holanda M. Furtado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz Moreira","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Angelo Goes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"issue":"9","key":"pone.0331332.ref001","article-title":"Serum soluble-fas, inflammation, and anemia in acute kidney injury","volume":"42","author":"MA G\u00f3es","year":"2018","journal-title":"Artif Organs"},{"issue":"2","key":"pone.0331332.ref002","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/ckj\/sfaa184","article-title":"Anemia following acute kidney injury after noncardiac surgery and long-term outcomes: the NARA-AKI cohort study","volume":"14","author":"M Nishimoto","year":"2020","journal-title":"Clin Kidney J"},{"issue":"5","key":"pone.0331332.ref003","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1177\/0885066608320836","article-title":"Anemia of inflammation in critically ill patients","volume":"23","author":"KC Sihler","year":"2008","journal-title":"J Intensive Care Med"},{"key":"pone.0331332.ref004","article-title":"Relation between red blood cell distribution width and acute kidney injury in patients with sepsis","volume":"20","author":"MLV Ramires","year":"2022","journal-title":"Einstein (Sao Paulo)"},{"issue":"2","key":"pone.0331332.ref005","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00134-022-06946-0","article-title":"Acute kidney injury","volume":"49","author":"M Ostermann","year":"2023","journal-title":"Intensive Care Med"},{"issue":"2","key":"pone.0331332.ref006","article-title":"Early sepsis-associated acute kidney injury and obesity","volume":"7","author":"YH Ahn","year":"2024","journal-title":"JAMA Netw Open"},{"issue":"1","key":"pone.0331332.ref007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000535641","article-title":"Effect on kidney function recovery guiding decongestion with VExUS in patients with cardiorenal syndrome 1: a randomized control trial","volume":"14","author":"JP Islas-Rodr\u00edguez","year":"2024","journal-title":"Cardiorenal Med"},{"issue":"2","key":"pone.0331332.ref008","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1097\/TA.0000000000002147","article-title":"Persistent inflammation and anemia among critically ill septic patients","volume":"86","author":"TJ Loftus","year":"2019","journal-title":"J Trauma Acute Care Surg"},{"key":"pone.0331332.ref009","doi-asserted-by":"crossref","first-page":"8121611","DOI":"10.1155\/2022\/8121611","article-title":"Week-one anaemia was associated with increased one-year mortality in critically Ill surgical patients","volume":"2022","author":"F-H Wu","year":"2022","journal-title":"Int J Clin Pract"},{"issue":"1","key":"pone.0331332.ref010","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/ejhf.2393","article-title":"Additional burden of iron deficiency in heart failure patients beyond the cardio-renal anaemia syndrome: findings from the BIOSTAT-CHF study","volume":"24","author":"RIS Alnuwaysir","year":"2022","journal-title":"Eur J Heart Fail"},{"issue":"5","key":"pone.0331332.ref011","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1159\/000507859","article-title":"Red blood cell distribution width and neutrophil-to-lymphocyte ratio in predicting adverse outcomes of acute kidney injury in hospitalized patients","volume":"6","author":"J Zhu","year":"2020","journal-title":"Kidney Dis (Basel)"},{"issue":"4","key":"pone.0331332.ref012","doi-asserted-by":"crossref","first-page":"362","DOI":"10.5603\/CJ.a2019.0020","article-title":"Anisocytosis predicts postoperative renal replacement therapy in patients undergoing heart valve surgery","volume":"27","author":"P Duchnowski","year":"2020","journal-title":"Cardiol J"},{"issue":"3","key":"pone.0331332.ref013","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1515\/jomb-2017-0054","article-title":"Red blood cell distribution width improves reclassification of patients admitted to the emergency department with acute decompensated heart failure","volume":"37","author":"G Turcato","year":"2018","journal-title":"J Med Biochem"},{"key":"pone.0331332.ref014","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.2147\/DMSO.S377650","article-title":"Influence of red blood cell distribution width on all-cause death in critical diabetic patients with acute kidney injury","volume":"15","author":"M Mo","year":"2022","journal-title":"Diabetes Metab Syndr Obes"},{"key":"pone.0331332.ref015","doi-asserted-by":"crossref","first-page":"997853","DOI":"10.3389\/fimmu.2022.997853","article-title":"Diagnostic value of RDW for the prediction of mortality in adult sepsis patients: a systematic review and meta-analysis","volume":"13","author":"H Wu","year":"2022","journal-title":"Front Immunol"},{"issue":"6","key":"pone.0331332.ref016","doi-asserted-by":"crossref","first-page":"807","DOI":"10.2169\/internalmedicine.3691-24","article-title":"Prognostic impact of the ratio of hemoglobin to red blood cell distribution width in patients after acute decompensated heart failure","volume":"64","author":"Y Kanzaki","year":"2025","journal-title":"Intern Med"},{"issue":"27","key":"pone.0331332.ref017","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","article-title":"2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: the task force for the diagnosis and treatment of acute and chronic heart failure of the european society of cardiology (ESC) developed with the special contribution of the heart failure association (HFA) of the ESC","volume":"37","author":"P Ponikowski","year":"2016","journal-title":"Eur Heart J"},{"issue":"11","key":"pone.0331332.ref018","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s00134-021-06506-y","article-title":"Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021","volume":"47","author":"L Evans","year":"2021","journal-title":"Intensive Care Med"},{"key":"pone.0331332.ref019","article-title":"NEWS 2: an opportunity to standardise the management of deterioration and sepsis","volume":"360","author":"M Inada-Kim","year":"2018","journal-title":"BMJ"},{"issue":"4","key":"pone.0331332.ref020","doi-asserted-by":"crossref","first-page":"216","DOI":"10.4266\/acc.2018.00178","article-title":"Performance of APACHE IV in medical intensive care unit patients: comparisons with APACHE II, SAPS 3, and MPM0 III","volume":"33","author":"M Ko","year":"2018","journal-title":"Acute Crit Care"},{"issue":"7","key":"pone.0331332.ref021","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.2215\/CJN.06150613","article-title":"Assessment of KDIGO definitions in patients with histopathologic evidence of acute renal disease","volume":"9","author":"R Chu","year":"2014","journal-title":"Clin J Am Soc Nephrol"},{"issue":"2","key":"pone.0331332.ref022","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.kint.2020.04.020","article-title":"Controversies in acute kidney injury: conclusions from a kidney disease: improving global outcomes (KDIGO) conference","volume":"98","author":"M Ostermann","year":"2020","journal-title":"Kidney Int"},{"issue":"4","key":"pone.0331332.ref023","doi-asserted-by":"crossref","DOI":"10.1159\/000339789","article-title":"KDIGO clinical practice guidelines for acute kidney injury","volume":"120","author":"A Khwaja","year":"2012","journal-title":"Nephron Clin Pract"},{"issue":"4","key":"pone.0331332.ref024","doi-asserted-by":"crossref","first-page":"771","DOI":"10.34067\/KID.0006012020","article-title":"AKI, anemia, and thrombocytopenia in a patient with leg and flank pain","volume":"2","author":"JI Lara Prado","year":"2021","journal-title":"Kidney360"},{"issue":"9","key":"pone.0331332.ref025","article-title":"The predictive value of RDW in AKI and mortality in patients with traumatic brain injury","volume":"34","author":"RR Wang","year":"2020","journal-title":"J Clin Lab Anal"},{"issue":"1","key":"pone.0331332.ref026","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/s12882-021-02379-x","article-title":"A novel risk-predicted nomogram for sepsis associated-acute kidney injury among critically ill patients","volume":"22","author":"S Yang","year":"2021","journal-title":"BMC Nephrol"},{"issue":"11","key":"pone.0331332.ref027","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1002\/bjs.9861","article-title":"Meta-analysis of the association between preoperative anaemia and mortality after surgery","volume":"102","author":"AJ Fowler","year":"2015","journal-title":"Br J Surg"},{"issue":"1","key":"pone.0331332.ref028","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1681\/ASN.2018070757","article-title":"Simple postoperative AKI Risk (SPARK) classification before noncardiac surgery: a prediction index development study with external validation","volume":"30","author":"S Park","year":"2019","journal-title":"J Am Soc Nephrol"},{"issue":"3","key":"pone.0331332.ref029","first-page":"186","article-title":"Effects of continuous renal replacement therapy on inflammation-related anemia, iron metabolism and prognosis in sepsis patients with acute kidney injury","volume":"14","author":"M-M An","year":"2023","journal-title":"World J Emerg Med"},{"issue":"10","key":"pone.0331332.ref030","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/nrneph.2016.113","article-title":"Heart failure and kidney dysfunction: epidemiology, mechanisms and management","volume":"12","author":"JC Schefold","year":"2016","journal-title":"Nat Rev Nephrol"},{"issue":"5","key":"pone.0331332.ref031","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1080\/14397595.2019.1645373","article-title":"Red cell distribution width, platelet-to-lymphocyte ratio, and mean platelet volume in ankylosing spondylitis and their correlations with inflammation: a meta-analysis","volume":"30","author":"GG Song","year":"2020","journal-title":"Mod Rheumatol"},{"issue":"1","key":"pone.0331332.ref032","doi-asserted-by":"crossref","first-page":"4563","DOI":"10.1038\/s41598-020-61516-y","article-title":"Red blood cell distribution width predicts long-term mortality in critically ill patients with acute kidney injury: a retrospective database study","volume":"10","author":"L Jia","year":"2020","journal-title":"Sci Rep"},{"issue":"6","key":"pone.0331332.ref033","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1159\/000485866","article-title":"Red Blood Cell Distribution Width is an Independent Predictor of AKI and Mortality in Patients in the Coronary Care Unit","volume":"42","author":"Y Hu","year":"2017","journal-title":"Kidney Blood Press Res"},{"issue":"2","key":"pone.0331332.ref034","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/ndt\/gfr307","article-title":"Red blood cell distribution width is an independent predictor of mortality in acute kidney injury patients treated with continuous renal replacement therapy","volume":"27","author":"HJ Oh","year":"2012","journal-title":"Nephrol Dial Transplant"},{"issue":"1","key":"pone.0331332.ref035","article-title":"Association of red blood cell distribution width and hemoglobin-to-RDW ratio with contrast-associated acute kidney injury in patients undergoing coronary angiography: A retrospective study","volume":"47","author":"L Zhu","year":"2024","journal-title":"Clin Cardiol"},{"issue":"12","key":"pone.0331332.ref036","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.jacc.2012.01.077","article-title":"Cardiorenal syndrome type 1: pathophysiological crosstalk leading to combined heart and kidney dysfunction in the setting of acutely decompensated heart failure","volume":"60","author":"C Ronco","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"pone.0331332.ref037","doi-asserted-by":"crossref","first-page":"20503121241228446","DOI":"10.1177\/20503121241228446","article-title":"Review of the limitations of current biomarkers in acute kidney injury clinical practices","volume":"12","author":"KB Bufkin","year":"2024","journal-title":"SAGE Open Med"},{"key":"pone.0331332.ref038","article-title":"Machine learning for predicting risk and prognosis of acute kidney disease in critically ill elderly patients during hospitalization: internet-based and interpretable model study","volume":"26","author":"M Li","year":"2024","journal-title":"J Med Internet Res"},{"issue":"4","key":"pone.0331332.ref039","doi-asserted-by":"crossref","first-page":"323","DOI":"10.21037\/atm-20-5723","article-title":"Development and validation of a risk stratification model for predicting the mortality of acute kidney injury in critical care patients","volume":"9","author":"H Huang","year":"2021","journal-title":"Ann Transl Med"},{"issue":"1","key":"pone.0331332.ref040","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/s12872-025-04632-9","article-title":"Association of hemoglobin-to-red blood cell distribution width ratio with mortality in critically Ill patients with heart failure and acute kidney injury: insights from the MIMIC-IV database","volume":"25","author":"X Xu","year":"2025","journal-title":"BMC Cardiovasc Disord"},{"issue":"3","key":"pone.0331332.ref041","doi-asserted-by":"crossref","first-page":"886","DOI":"10.3390\/jcm11030886","article-title":"The ratio of hemoglobin to red cell distribution width: a strong predictor of clinical outcome in patients with heart failure","volume":"11","author":"E Rahamim","year":"2022","journal-title":"J Clin Med"},{"issue":"3","key":"pone.0331332.ref042","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/SHK.0000000000001840","article-title":"Red cell distribution width at admission predicts the frequency of acute kidney injury and 28-day mortality in patients with acute respiratory distress syndrome","volume":"57","author":"N Cai","year":"2022","journal-title":"Shock"},{"key":"pone.0331332.ref043","author":"Y Tang","year":"2021"},{"issue":"4","key":"pone.0331332.ref044","doi-asserted-by":"crossref","first-page":"157","DOI":"10.5414\/CN111139","article-title":"Predictive value of red blood cell distribution width and platelet-to-lymphocyte ratio for acute kidney injury in critically ill patients","volume":"100","author":"J Fen","year":"2023","journal-title":"Clin Nephrol"},{"key":"pone.0331332.ref045","doi-asserted-by":"crossref","first-page":"1047933","DOI":"10.3389\/fmed.2023.1047933","article-title":"Association and prediction of red blood cell distribution width to albumin ratio in all-cause mortality of acute kidney injury in critically ill patients","volume":"10","author":"C Gao","year":"2023","journal-title":"Front Med (Lausanne)"},{"issue":"3","key":"pone.0331332.ref046","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1159\/000512587","article-title":"Red blood cell distribution width as a 5-year prognostic marker in patients submitted to carotid endarterectomy","volume":"10","author":"L Duarte-Gamas","year":"2020","journal-title":"Cerebrovasc Dis Extra"},{"issue":"7","key":"pone.0331332.ref047","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.3390\/antiox12071440","article-title":"Impaired NRF2 inhibits recovery from ischemic reperfusion injury in the aging kidney","volume":"12","author":"MJ Jo","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"pone.0331332.ref048","doi-asserted-by":"crossref","first-page":"754979","DOI":"10.3389\/fmed.2022.754979","article-title":"Acute Myocardial Infarction (AMI) as the effect modifiers to modify the association between red blood cell distribution width (RDW) and mortality in critically Ill patients with stroke","volume":"9","author":"T Guo","year":"2022","journal-title":"Front Med (Lausanne)"},{"issue":"27","key":"pone.0331332.ref049","doi-asserted-by":"crossref","first-page":"42650","DOI":"10.18632\/oncotarget.9516","article-title":"The ratio of hemoglobin to red cell distribution width as a novel prognostic parameter in esophageal squamous cell carcinoma: a retrospective study from southern China","volume":"7","author":"P Sun","year":"2016","journal-title":"Oncotarget"},{"key":"pone.0331332.ref050","doi-asserted-by":"crossref","first-page":"1354325","DOI":"10.3389\/fimmu.2024.1354325","article-title":"Ratio of hemoglobin to red cell distribution width: an inflammatory predictor of survival in AIDS-related DLBCL","volume":"15","author":"J Chen","year":"2024","journal-title":"Front Immunol"},{"issue":"7","key":"pone.0331332.ref051","article-title":"Assessing red blood cell distribution width in Vietnamese heart failure patients: a cross-sectional study","volume":"19","author":"HNN Dang","year":"2024","journal-title":"PLoS One"},{"issue":"2","key":"pone.0331332.ref052","article-title":"Association between red blood cell distribution width-to-albumin ratio at admission and all-cause mortality in patients with acute pancreatitis based on the MIMIC-III database","volume":"20","author":"Q Wu","year":"2025","journal-title":"PLoS One"},{"issue":"4","key":"pone.0331332.ref053","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0321789","article-title":"The red blood cell distribution width is associated with all-cause and cardiovascular mortality among individuals with non-alcoholic fatty liver disease","volume":"20","author":"Y Huang","year":"2025","journal-title":"PLoS One"},{"issue":"11","key":"pone.0331332.ref054","article-title":"Association of red cell distribution width and its changes with the 30-day mortality in patients with acute respiratory failure: An analysis of MIMIC-IV database","volume":"18","author":"Y Shi","year":"2023","journal-title":"PLoS One"},{"issue":"10","key":"pone.0331332.ref055","article-title":"Longitudinal modeling of red blood cell distribution width dynamics and mortality risk in critically Ill patients with sepsis-associated acute kidney injury","volume":"20","author":"R He","year":"2025","journal-title":"PLoS One"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0331332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T18:42:03Z","timestamp":1772217723000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0331332"}},"subtitle":[],"editor":[{"given":"Chiara","family":"Lazzeri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,2,27]]},"references-count":55,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0331332","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,27]]}}}