{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:24:54Z","timestamp":1788992694403,"version":"build-2803163510"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Young and Middle-aged Talents Training Project of Fujian Provincial Health Technology Project","award":["2021GGA021"],"award-info":[{"award-number":["2021GGA021"]}]},{"name":"Startup Fund for Scientific Research, Fujian Medical University","award":["2020QH1098"],"award-info":[{"award-number":["2020QH1098"]}]},{"name":"Joint Funds for the National Key Clinical Specialty Construction Projects of Fujian Province, China","award":["2023 \u2212 1594"],"award-info":[{"award-number":["2023 \u2212 1594"]}]},{"name":"Minimally Invasive Medical Center of Fujian, China","award":["[2017]171"],"award-info":[{"award-number":["[2017]171"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Gastric cancer is a serious health threat to people in Taiwan. This study reports gastric cancer burden and trends in Taiwan, from 1990 to 2021, and projects the incidence and mortality trends through 2036.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Data on gastric cancer burden in Taiwan came from the 2021 GBD database. Trend changes were evaluated via joinpoint analysis, with the Age-Period-Cohort model estimating age, period, and cohort influences. Decomposition analysis measured contributions of population growth, aging, and epidemiological factors, and the BAPC model forecast future burden.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Between 1990 and 2021, the age-standardized incidence rate (ASIR), age-standardized prevalence rate (ASPR), age-standardized mortality rate (ASMR), and age-standardized disability-adjusted life-year (DALY) rate (ASDR) of gastric cancer in Taiwan all showed a decreasing trend. In terms of absolute burden, the number of incident cases in 2021 was 4,839 (95% uncertainty interval [UI]: 4,272\u20135,352), representing a 41.20% increase, prevalent cases reached 9,835 (95% UI: 8,664\u201311,032), a 60.36% rise, deaths totaled 3,799 (95% UI: 3,345\u20134,220), up by 29.17%, and DALYs were 79,425 (95% UI: 71,168\u201387,813), with a 0.19% decrease. A significant gender disparity was observed, with males bearing a heavier burden. Projections indicate that incident cases and deaths will continue to rise through 2036.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Across the past 32 years, gastric cancer in Taiwan has exhibited a declining relative burden, yet the absolute burden has risen consistently and is forecast to keep increasing over the next 15 years. Precision risk control measures and context-specific public health policies are required to alleviate this burden.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0331506","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T17:39:41Z","timestamp":1757698781000},"page":"e0331506","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Trend analysis and projection of the gastric cancer disease burden in Taiwan during 1990\u20132021: An analysis of the global burden of disease study 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