{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T14:08:04Z","timestamp":1777212484649,"version":"3.51.4"},"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82160880"],"award-info":[{"award-number":["82160880"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>To elucidate the molecular mechanism of dragon\u2019s blood (DB) in the treatment of ulcerative colitis (UC).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Bioactive metabolites of DB absorbed into the bloodstream were characterized via LC-MS. Network pharmacology and molecular docking were employed to construct a target-pathway interaction model predicting DB\u2019s therapeutic mechanism in UC. A 4% DSS-induced UC mouse model was used for experimental validation.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>DB markedly alleviated colonic injury in DSS-induced UC. A total of 255 active compounds were identified, including 6,4\u2019-Dimethoxy-7-hydroxyisoflavone, 7-hydroxy-2-(4-methoxyphenyl) chromen-4-one, and Apigenin. Key molecular targets included NLPR3, MAPK1, TP53, HIF1A, and PTGS2. The NF-\u03baB\/NLPR3\/Caspase-1 axis was implicated as a central pathway mediating the therapeutic effects of DB.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>DB acts through a multi-component, multi-target, and multi-pathway strategy. Inhibiting the NF-\u03baB\/NLPR3\/Caspase-1 pyroptosis pathway positions NLPR3 as a viable target for DB in UC intervention.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0331570","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T17:34:21Z","timestamp":1758303261000},"page":"e0331570","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Molecular mechanisms of dragon\u2019s blood in treating ulcerative colitis based on NF-\u03bab\/NLPR3\/Caspase-1 pyroptosis signaling 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