{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:24:48Z","timestamp":1791347088022,"version":"4.3.1"},"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Programme for Prevention, Surveillance, and Control of Transmissible Diseases (PREVICET), CIBER de Epidemiolog\u00c3a y Salud P\u00c3\u00bablica (CIBERESP), Instituto de Salud Carlos III, Madrid","award":["ESPC43\/2024"],"award-info":[{"award-number":["ESPC43\/2024"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Hepatitis A is an acute disease of the liver caused by the hepatitis A virus (HAV). Chronic liver disease, other viral hepatitis coinfections, and age over 50 years are the main host factors associated with an increased risk of complications. We investigated the evolution of hepatitis A hospitalizations and in-hospital deaths during 2000\u20132021 in Spain according to demographic characteristics, presence of other sexually transmitted infections, and vaccination strategy (universal or risk-group vaccination).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Using data from the Spanish National Health System\u2019s Minimum Basic Data Set, we calculated age-standardized cumulative hospitalization incidence and 95% confidence interval (CI), factors associated with hospital stay, and hospitalization deaths. Adjusted OR (aOR) values were calculated using a multivariate logistic regression model.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The Spanish cumulative hospitalization incidence for hepatitis A over the 22-year period was 8.84 per 1 000 000 globally and 12.54 and 5.26 per 1 000 000 for men and women, respectively (RR\u2009=\u20092.38; 95% CI: 2.28\u20132.50). Median length of stay was 4 days (range 0\u221285). Factors associated with hospitalization &gt;7 days were age groups 40\u221259 and \u226560 years (aOR 1.58; 95% CI: 1.37\u20131.82 and aOR 5.09; 95% CI: 4.01\u20136.47, respectively), cirrhosis (aOR 6.11; 95% CI: 2.59\u201314.43), and presence of HIV and HBV (aOR 1.65; 95% CI: 1.15\u20132.38 and 2.01; 95% CI: 1.03\u20133.63, respectively). In-hospital deaths were associated with age\u2009\u2265\u200960 years (aOR 35.23; 95% CI: 11.12\u2013111.58), hospitalization &gt;7 days (aOR 4.37; 95% CI: 1.80\u201310.58), cirrhosis (aOR 8.84; 95% CI: 2.37\u201332.99), and HCV infection (aOR 8.66; 95% CI: 1.57\u201347.87). The cumulative hospitalization incidence was lower in regions implementing universal vaccination (RR 0.79; 95% CI: 0.75\u20130.84).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Results of studies based on characteristics of hospitalized hepatitis A cases taking into account the existing prevention policies can be useful to have a better knowledge about its evolving epidemiology and to improve the prevention and control of the disease.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0332317","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T17:39:01Z","timestamp":1758735541000},"page":"e0332317","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hepatitis A in Spain: Evolution of hospitalization in the period 2000\u20132021"],"prefix":"10.1371","volume":"20","author":[{"given":"Angela","family":"Dom\u00ednguez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Torner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1353-5325","authenticated-orcid":true,"given":"N\u00faria","family":"Soldevila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Varela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Guerrero-Vadillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5909-7957","authenticated-orcid":true,"given":"Marina","family":"Pe\u00f1uelas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Avell\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Borr\u00e0s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Plans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carles","family":"Pericas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Rius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pere","family":"Godoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"pone.0332317.ref001","first-page":"365","article-title":"Hepatitis 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