{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T09:14:19Z","timestamp":1785316459286,"version":"3.55.0"},"reference-count":82,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019889","name":"Weston Family Foundation","doi-asserted-by":"publisher","award":["RR161096"],"award-info":[{"award-number":["RR161096"]}],"id":[{"id":"10.13039\/100019889","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This research explores the relationship between baseline performance in dementia patients and its impact on the effectiveness of transcranial direct current stimulation (tDCS) for improving executive function. Past research suggests that those participants who are more impaired at baseline will be those who then demonstrate the greatest improvements with tDCS. In addition, we examined if bilateral or unilateral stimulation would be more effective for improving the general level of cognition of these participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>The study involved 24 participants, with 18 diagnosed with Alzheimer\u2019s disease (AD) and 6 with Frontotemporal Dementia (FTD). These participants engaged in three rounds of N-back task training sessions, each separated by two months. The sessions included three types of stimulation: 4mA unilateral stimulation targeting the left Dorsolateral Prefrontal Cortex (DLPFC), 4mA bilateral stimulation targeting both the left and right DPFC, and sham stimulation. Additionally, a control group of elderly individuals without dementia was used to establish a benchmark for the normal average response time (RT) of the administered N-Back task. Evaluations, comprising of the N-Back task and the Mini-Mental State Examination (MMSE), were conducted before stimulation, at the final session, and two weeks post-stimulation in all rounds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Participants were retrospectively allocated into those whose baseline N-Back response times (RTs) were found on average to be within the normal range versus those who performed more slowly than the normal range. For the group that performed within the normal range, no significant improvement was observed on the N-Back task after a series of sessions involving active tDCS. In contrast, the participants with slower than normal RTs at baseline demonstrated improvement both on the N-Back task (faster times) and the MMSE (higher scores) after receiving active tDCS, although accompanying improvement on the MMSE task was restricted to the condition where participants received bilateral tDCS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study replicates a pervasive finding in the tDCS literature: participants who perform worse at baseline often demonstrate the greatest improvements with tDCS. Furthermore, these results have clinical implications, in that tDCS may be most beneficial in individuals when clear deficits or impairments are present. Attempts to treat less severe participants might fail to show improvement with tDCS. Ultimately, baseline condition should be routinely considered when evaluating tDCS results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0332372","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T17:46:18Z","timestamp":1761759978000},"page":"e0332372","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Baseline task performance predicts mini-mental state examination improvement after individuals with dementia practice an N-back task with bilateral transcranial direct current 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Mangia","year":"2014","journal-title":"Front Hum Neurosci"},{"key":"pone.0332372.ref042","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3389\/fnhum.2013.00529","article-title":"Modulation of spontaneous alpha brain rhythms using low-intensity transcranial direct-current stimulation","volume":"7","author":"GF Spitoni","year":"2013","journal-title":"Front Hum Neurosci"},{"key":"pone.0332372.ref043","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.neulet.2015.01.014","article-title":"Anodal transcranial direct current stimulation (tDCS) increases frontal-midline theta activity in the human EEG: a preliminary investigation of non-invasive stimulation","volume":"588","author":"J Miller","year":"2015","journal-title":"Neurosci Lett"},{"issue":"4","key":"pone.0332372.ref044","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0197-4580(00)00153-6","article-title":"Quantitative electroencephalography in mild cognitive impairment: longitudinal changes 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Gratton","year":"2018","journal-title":"Psychophysiology"},{"issue":"6","key":"pone.0332372.ref051","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1007\/s10548-019-00744-6","article-title":"Towards a Universal Taxonomy of Macro-scale Functional Human Brain Networks","volume":"32","author":"LQ Uddin","year":"2019","journal-title":"Brain Topogr"},{"issue":"4","key":"pone.0332372.ref052","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.brs.2009.03.005","article-title":"Gyri-precise head model of transcranial direct current stimulation: improved spatial focality using a ring electrode versus conventional rectangular pad","volume":"2","author":"A Datta","year":"2009","journal-title":"Brain Stimul"},{"issue":"3","key":"pone.0332372.ref053","first-page":"189","article-title":"\u201cMini-mental state\u201d. 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A"},{"issue":"12","key":"pone.0332372.ref069","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.tics.2008.09.004","article-title":"State-dependency in brain stimulation studies of perception and cognition","volume":"12","author":"J Silvanto","year":"2008","journal-title":"Trends Cogn Sci"},{"issue":"11","key":"pone.0332372.ref070","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.1111\/cns.14314","article-title":"The effects of noninvasive brain stimulation on cognitive function in patients with mild cognitive impairment and Alzheimer\u2019s disease using resting-state functional magnetic resonance imaging: A systematic review and meta-analysis","volume":"29","author":"T Wang","year":"2023","journal-title":"CNS Neurosci Ther"},{"key":"pone.0332372.ref071","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jns.2012.03.025","article-title":"Hereditary spastic paraplegias with autosomal dominant, recessive, X-linked, or maternal trait of inheritance","volume":"318","author":"J Finsterer","year":"2012","journal-title":"J Neurol Sci"},{"issue":"8","key":"pone.0332372.ref072","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1162\/jocn_a_00956","article-title":"Does Transcranial Direct Current Stimulation Improve Healthy Working Memory?: A Meta-analytic Review","volume":"28","author":"LE Mancuso","year":"2016","journal-title":"J Cogn Neurosci"},{"issue":"10","key":"pone.0332372.ref073","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1007\/s00221-014-4022-x","article-title":"Use of transcranial direct current stimulation (tDCS) to enhance cognitive training: effect of timing of stimulation","volume":"232","author":"DM Martin","year":"2014","journal-title":"Exp Brain Res"},{"issue":"10","key":"pone.0332372.ref074","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.1523\/JNEUROSCI.5308-13.2014","article-title":"Transcranial direct current stimulation over right dorsolateral prefrontal cortex enhances error awareness in older age","volume":"34","author":"S Harty","year":"2014","journal-title":"J Neurosci"},{"issue":"3","key":"pone.0332372.ref075","article-title":"Multilocus sequence typing and antibiotic resistance of Aeromonas isolated from freshwater fish in Hebei Province","volume":"19","author":"Z Yu","year":"2024","journal-title":"PLoS One"},{"issue":"5","key":"pone.0332372.ref076","doi-asserted-by":"crossref","first-page":"585","DOI":"10.5535\/arm.2012.36.5.585","article-title":"Improvement of the working memory and naming by transcranial direct current stimulation","volume":"36","author":"SY Jeon","year":"2012","journal-title":"Ann Rehabil Med"},{"issue":"6","key":"pone.0332372.ref077","doi-asserted-by":"crossref","first-page":"066017","DOI":"10.1088\/1741-2560\/8\/6\/066017","article-title":"A finite element analysis of the effect of electrode area and inter-electrode distance on the spatial distribution of the current density in tDCS","volume":"8","author":"P Faria","year":"2011","journal-title":"J Neural Eng"},{"key":"pone.0332372.ref078","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3389\/fnhum.2013.00183","article-title":"A Comparison between Uni- and Bilateral tDCS Effects on Functional Connectivity of the Human Motor Cortex","volume":"7","author":"B Sehm","year":"2013","journal-title":"Front Hum Neurosci"},{"issue":"26","key":"pone.0332372.ref079","doi-asserted-by":"crossref","first-page":"8988","DOI":"10.1523\/JNEUROSCI.0536-12.2012","article-title":"Global connectivity of prefrontal cortex predicts cognitive control and intelligence","volume":"32","author":"MW Cole","year":"2012","journal-title":"J Neurosci"},{"issue":"3","key":"pone.0332372.ref080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0247586","article-title":"Conservation genetics of the threatened plant species Physaria filiformis (Missouri bladderpod) reveals strong genetic structure and a possible cryptic species","volume":"16","author":"CE Edwards","year":"2021","journal-title":"PLoS One"},{"issue":"4","key":"pone.0332372.ref081","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/npp.2012.237","article-title":"Clinically meaningful efficacy and acceptability of low-frequency repetitive transcranial magnetic stimulation (rTMS) for treating primary major depression: a meta-analysis of randomized, double-blind and sham-controlled trials","volume":"38","author":"MT Berlim","year":"2013","journal-title":"Neuropsychopharmacology"},{"issue":"2","key":"pone.0332372.ref082","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1017\/S0033291713000512","article-title":"Response, remission and drop-out rates following high-frequency repetitive transcranial magnetic stimulation (rTMS) for treating major depression: a systematic review and meta-analysis of randomized, double-blind and sham-controlled trials","volume":"44","author":"MT Berlim","year":"2014","journal-title":"Psychol Med"}],"container-title":["PLOS 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