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To improve control of <jats:italic>S<\/jats:italic>. Dublin, we (i) developed a mathematical model of <jats:italic>S.<\/jats:italic> Dublin transmission on a HRO, (ii) evaluated the vaccine effectiveness and cleaning improvements for controlling the infection, and (iii) evaluated the influence of infection and control strategies on the HRO\u2019s operating income. We developed a modified Susceptible-Infected-Recovered-Susceptible model of <jats:italic>S.<\/jats:italic> Dublin spread in a batch-stocking HRO post-introduction of an index case, with stochasticity introduced through Monte Carlo simulations. Epidemiological outcomes (<jats:italic>S.<\/jats:italic> Dublin-induced deaths and abortions during raising and <jats:italic>S.<\/jats:italic> Dublin carriers and asymptomatic infections among raised replacement heifers) and operating income per 100-head raised on a HRO over a 2-year simulation were compared between control scenarios. We validated our model against <jats:italic>S.<\/jats:italic> Dublin infection data in cattle. Partial rank correlation coefficient analysis and classification trees were used to determine parameter influence on model outcomes. Our model predicts a median of 37 carriers and 92 asymptomatic infections among raised replacement heifers out of 2,330 heifers that departed the operation by the end of the 2-year simulation period, suggesting a relevant role of HROs in spreading <jats:italic>S<\/jats:italic>. Dublin. Increasing barn floor cleaning frequency (to a maximum of 12x per day) meaningfully reduced the <jats:italic>S.<\/jats:italic> Dublin epidemiological outcomes and improved the HRO\u2019s operating income. Depending on the cost of cleaning, the median operating income increased between 1.2% to 10.6% in the first year when cleaning 12x per day compared to baseline (cleaning 1x per week). In most cost scenarios, predictions do not support using a vaccine that solely reduces mortality, even when paired with stringent cleaning measures. The developed model is expected to aid efforts to control <jats:italic>S.<\/jats:italic> Dublin in HROs.<\/jats:p>","DOI":"10.1371\/journal.pone.0332465","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T17:35:12Z","timestamp":1760636112000},"page":"e0332465","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Integration of mathematical modeling and economics approaches to evaluate strategies for control of Salmonella Dublin in a heifer-raising operation"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0110-041X","authenticated-orcid":true,"given":"Sebastian","family":"Llanos-Soto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4168-5662","authenticated-orcid":true,"given":"Martin","family":"Wiedmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Adalja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Henry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Moroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisha","family":"Frye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco A.","family":"Leal Yepes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Ivanek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,10,16]]},"reference":[{"issue":"8","key":"pone.0332465.ref001","doi-asserted-by":"crossref","first-page":"4208","DOI":"10.1128\/JCM.43.8.4208-4211.2005","article-title":"Dissemination of Salmonella enterica subsp. enterica Serovar Typhimurium var. 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