{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T01:12:41Z","timestamp":1761181961670,"version":"build-2065373602"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Genentech Patient Foundation"},{"name":"Genentech, Inc"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Sexual and gender minority (SGM) people often experience significant health disparities and poor health outcomes. The objective of this study was to assess the feasibility and outcomes of sexual orientation and gender identity (SOGI) data collection in 2 distinct survey settings: (1) clinical research and (2) patient assistance programs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>In this survey study, participants completed 1 of 2 separate, distinct, self-reported, optional, United States\u2013based surveys: (1) an in-person survey at clinical research sites for a cough or cardiac study between December 2022 to December 2023 (sponsored by Genentech) or (2) a web-based patient assistance program survey from a patient assistance program between January 2023 to December 2023 (sponsored by the Genentech Patient Foundation).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 33 clinical research survey participants, 100% of participants answered SOGI-related questions, leading to a non-response rate of 0%. Most (87.88%) participants identified as cisgender; 84.85% identified as heterosexual, 3.03% bisexual, 3.03% gay, 3.03% questioning, and 6.06% preferred not to answer.<\/jats:p>\n                    <jats:p>Of 8499 patient assistance program survey participants, 99.54% answered gender identity questions (non-response rate of 0.46%) and 95.92% answered sexual orientation questions (non-response rate of 4.08%). Gender identities in the patient assistance program survey included 61.30% female, 34.22% male, 0.12% genderqueer, 0.06% transgender male, 0.14% none of the options, and 4.16% \u201cPrefer not to answer.\u201d Self-reported non-heterosexual orientations included bisexual, gay, lesbian, queer, questioning, \u201cPrefer not to answer,\u201d and something else.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that patients in both survey settings are willing to self-disclose sexual orientation and gender identity information. These results underscore the rationale for adopting SOGI data collection in these settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec005\">\n                    <jats:title>Clinical trials<\/jats:title>\n                    <jats:p>NCT05660850, ISRCTN10520571<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0332805","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:37:47Z","timestamp":1761154667000},"page":"e0332805","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sexual orientation and gender identity data: An observational study assessing the feasibility of SOGI collection in clinical research and patient assistance programs"],"prefix":"10.1371","volume":"20","author":[{"given":"Isabel","family":"Brown","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thuan","family":"Tran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"Funwie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilpen","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0167-7335","authenticated-orcid":true,"given":"Meghan","family":"McKenzie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"issue":"10","key":"pone.0332805.ref001","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.2105\/AJPH.2012.301110","article-title":"Health disparities among lesbian, gay, and bisexual older adults: results from a population-based study","volume":"103","author":"KI Fredriksen-Goldsen","year":"2013","journal-title":"Am J Public Health"},{"issue":"8","key":"pone.0332805.ref002","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.2105\/AJPH.2017.303922","article-title":"Chronic health conditions and key health indicators among lesbian, gay, and bisexual older US adults, 2013-2014","volume":"107","author":"KI Fredriksen-Goldsen","year":"2017","journal-title":"Am J Public Health"},{"issue":"9","key":"pone.0332805.ref003","first-page":"845","article-title":"Cancer diagnoses among lesbian, gay, and bisexual adults: results from the 2013-2016 National Health Interview Survey","volume":"29","author":"G Gonzales","year":"2018","journal-title":"Cancer Causes Control"},{"issue":"1","key":"pone.0332805.ref004","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1186\/s12889-017-4937-9","article-title":"Health and healthcare disparities among U.S. women and men at the intersection of sexual orientation and race\/ethnicity: a nationally representative cross-sectional study","volume":"17","author":"M-H Trinh","year":"2017","journal-title":"BMC Public Health"},{"key":"pone.0332805.ref005","volume-title":"AACR conference examines cancer disparities in the LGBTQ population","author":"K Olsen"},{"issue":"1","key":"pone.0332805.ref006","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1177\/10731911211042933","article-title":"Development and validation of two abbreviated intraminority gay community stress scales","volume":"30","author":"AJ Maiolatesi","year":"2023","journal-title":"Assessment"},{"issue":"6","key":"pone.0332805.ref007","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1080\/00918369.2015.1112193","article-title":"Sources of discrimination and their associations with health in sexual minority sdults","volume":"63","author":"WS Figueroa","year":"2016","journal-title":"J Homosex"},{"issue":"3","key":"pone.0332805.ref008","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1177\/00221465211016436","article-title":"Health and health care of sexual and gender minorities","volume":"62","author":"N Hsieh","year":"2021","journal-title":"J Health Soc Behav"},{"key":"pone.0332805.ref009","unstructured":"National Cancer Institute. 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