{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:55:08Z","timestamp":1790153708392,"version":"4.0.1"},"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Primary Sj\u00f6gren\u2019s syndrome (pSS) is an autoimmune and inflammatory disorder that may affect the lungs, leading to interstitial lung disease (ILD). However, the diagnosis of progression from pSS to ILD is frequently delayed due to unstandardized interdisciplinary diagnostic criteria and a lack of reliable shared biomarkers. This diagnostic challenge, compounded by significant pathophysiological divergence in target organs, has hindered elucidation of their comorbidity mechanisms. This study employs integrated bioinformatics to identify shared biomarkers in pSS and ILD, deciphers their pathogenic mechanisms, and predicts targeted therapeutics via network pharmacology<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>From the Gene Expression Omnibus (GEO) database, we retrieved gene expression profiles of pSS and ILD. Differential expression gene (DEG) analysis was performed on the profiles, followed by further screening using four machine learning algorithms. Concurrently, weighted gene co-expression network analysis (WGCNA) was applied to identify gene modules, and enrichment analysis of WGCNA-derived genes was conducted to explore their biological functions. Genes obtained from WGCNA and machine learning approaches were then intersected to identify candidate biomarkers for pSS-ILD. The diagnostic potential of these candidate genes was evaluated in both discovery and validation sets using receiver operating characteristic (ROC) curves. Finally, we performed immune cell infiltration analysis of candidate genes, regulatory network construction for transcription factor (TF)-gene and miRNA-gene interactions, drug-target prediction, and molecular docking coupled with molecular dynamics simulations for predicted drugs.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Differential expression analysis identified 25 shared genes between pSS and ILD gene expression profiles, with machine learning algorithms refining six key genes from these DEGs. WGCNA revealed 39 intersecting genes significantly enriched in biological processes including cell division, oocyte maturation, and metabolic regulation. Intersection of machine learning and WGCNA results yielded two hub genes (CYSLTR1 and SIGLEC10), both demonstrating robust diagnostic value in discovery and validation cohorts. Immune cell infiltration profiling showed: upregulation of activated CD4+ memory T cells and memory B cells; downregulation of resting NK cells. Regulatory network analysis indicated FOXC1, hsa-mir-27a-3p, hsa-mir-195-5p, and hsa-miR-26a-5p as potential coregulators of CYSLTR1 and SIGLEC10 expression. Finally, ten candidate drug compounds targeting the hub genes were prioritized, exemplified by:Rev-5901 (CTD 00002161), Zafirlukast (BOSS database) and Montelukast (CTD 00003205). Molecular docking demonstrated substantial binding affinity of both montelukast and zafirlukast for CYSLTR1, while molecular dynamics simulations further validated the stability of their complexes.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>This study revealed that CYSLTR1 and SIGLEC10 demonstrate diagnostic potential for pSS-ILD. Their mechanism of action likely involves synergistically upregulating memory B cells to promote disease progression. Furthermore, we identified montelukast as a potential therapeutic agent. This discovery holds promise for improving clinical outcomes for pSS-ILD patients.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0333070","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T17:25:03Z","timestamp":1759771503000},"page":"e0333070","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Exploration common biomarkers and pathogenesis of primary Sj\u00f6gren\u2019s syndrome and interstitial lung disease by machine learning and weighted gene co-expression networks"],"prefix":"10.1371","volume":"20","author":[{"given":"Jingqi","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zelin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3656-354X","authenticated-orcid":true,"given":"Shufen","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"issue":"9482","key":"pone.0333070.ref001","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0140-6736(05)66990-5","article-title":"Sj\u00f6gren\u2019s syndrome","volume":"366","author":"RI Fox","year":"2005","journal-title":"Lancet"},{"issue":"8","key":"pone.0333070.ref002","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41584-024-01135-3","article-title":"Update on the pathophysiology and treatment of primary Sj\u00f6gren syndrome","volume":"20","author":"C Baldini","year":"2024","journal-title":"Nat Rev Rheumatol"},{"issue":"20","key":"pone.0333070.ref003","first-page":"354","article-title":"The diagnosis and treatment of Sj\u00f6gren\u2019s syndrome","volume":"114","author":"AL Stefanski","year":"2017","journal-title":"Dtsch Arztebl Int"},{"issue":"1","key":"pone.0333070.ref004","doi-asserted-by":"crossref","first-page":"110767","DOI":"10.1016\/j.ygeno.2023.110767","article-title":"Integrative analysis of transcriptome and proteome in primary Sj\u00f6gren syndrome","volume":"116","author":"X Qiu","year":"2024","journal-title":"Genomics"},{"issue":"5","key":"pone.0333070.ref005","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1513\/AnnalsATS.201808-565CME","article-title":"Interstitial pneumonia with autoimmune features","volume":"16","author":"BA Graney","year":"2019","journal-title":"Ann Am Thorac Soc"},{"issue":"131","key":"pone.0333070.ref006","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1183\/09059180.00009113","article-title":"Interstitial lung disease","volume":"23","author":"KM Antoniou","year":"2014","journal-title":"Eur Respir Rev"},{"key":"pone.0333070.ref007","doi-asserted-by":"crossref","first-page":"1288098","DOI":"10.3389\/fimmu.2023.1288098","article-title":"The molecular mechanism underlying dermatomyositis related interstitial lung disease: evidence from bioinformatic analysis and in vivo validation","volume":"14","author":"L Zeng","year":"2023","journal-title":"Front Immunol"},{"issue":"7","key":"pone.0333070.ref008","article-title":"Identification and validation of mutual hub genes in idiopathic pulmonary fibrosis and rheumatoid arthritis-associated usual interstitial pneumonia","volume":"10","author":"L Chen","year":"2024","journal-title":"Heliyon"},{"key":"pone.0333070.ref009","doi-asserted-by":"crossref","first-page":"795034","DOI":"10.3389\/fgene.2021.795034","article-title":"The downregulation of PTGS2 mediated by ncRNAs is tightly correlated with systemic sclerosis-interstitial lung disease","volume":"12","author":"Z Xu","year":"2022","journal-title":"Front Genet"},{"issue":"7","key":"pone.0333070.ref010","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.3390\/jcm12072586","article-title":"Interstitial lung disease and pulmonary damage in primary Sj\u00f6gren\u2019s syndrome: a systematic review and meta-analysis","volume":"12","author":"O Berardicurti","year":"2023","journal-title":"J Clin Med"},{"issue":"1","key":"pone.0333070.ref011","doi-asserted-by":"crossref","first-page":"108","DOI":"10.31138\/mjr.230323.cca","article-title":"Clinical characteristics and outcomes of interstitial lung disease in primary Sj\u00f6gren\u2019s syndrome: a retrospective cohort study","volume":"35","author":"P Manikuppam","year":"2024","journal-title":"Mediterr J Rheumatol"},{"issue":"35","key":"pone.0333070.ref012","article-title":"Characteristics and mortality in primary Sj\u00f6gren syndrome-related interstitial lung disease","volume":"100","author":"H Gao","year":"2021","journal-title":"Medicine (Baltimore)"},{"issue":"10","key":"pone.0333070.ref013","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.3390\/jcm12103428","article-title":"Primary-Sj\u00f6gren\u2019s-syndrome-related interstitial lung disease: a clinical review discussing current controversies","volume":"12","author":"G La Rocca","year":"2023","journal-title":"J Clin Med"},{"issue":"2","key":"pone.0333070.ref014","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/art.40769","article-title":"Proceedings of the American College of Rheumatology\/Association of Physicians of Great Britain and Ireland Connective Tissue Disease-Associated Interstitial Lung Disease Summit: a multidisciplinary approach to address challenges and opportunities","volume":"71","author":"A Fischer","year":"2019","journal-title":"Arthritis Rheumatol"},{"key":"pone.0333070.ref015","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13075-019-1835-9","article-title":"Serum KL-6 levels reflect the severity of interstitial lung disease associated with connective tissue disease","volume":"21","author":"JS Lee","year":"2019","journal-title":"Arthritis Res Therapy"},{"issue":"2","key":"pone.0333070.ref016","doi-asserted-by":"crossref","first-page":"102447","DOI":"10.1016\/j.autrev.2019.102447","article-title":"Clinical, morphological features and prognostic factors associated with interstitial lung disease in primary Sj\u04e7gren\u2019s syndrome: a systematic review from the Italian Society of Rheumatology","volume":"19","author":"G Sambataro","year":"2020","journal-title":"Autoimmun Rev"},{"issue":"11","key":"pone.0333070.ref017","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1007\/s10067-018-4289-6","article-title":"A retrospective analysis of distinguishing features of chest HRCT and clinical manifestation in primary Sj\u00f6gren\u2019s syndrome-related interstitial lung disease in a Chinese population","volume":"37","author":"X Dong","year":"2018","journal-title":"Clin Rheumatol"},{"key":"pone.0333070.ref018","doi-asserted-by":"crossref","first-page":"105895","DOI":"10.1016\/j.rmed.2020.105895","article-title":"Anti-Ro52 antibodies are a risk factor for interstitial lung disease in primary Sj\u00f6gren syndrome","volume":"163","author":"C Buvry","year":"2020","journal-title":"Respir Med"},{"issue":"1","key":"pone.0333070.ref019","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1136\/annrheumdis-2019-216114","article-title":"EULAR recommendations for the management of Sj\u00f6gren\u2019s syndrome with topical and systemic therapies","volume":"79","author":"M Ramos-Casals","year":"2020","journal-title":"Ann Rheum Dis"},{"issue":"10309","key":"pone.0333070.ref020","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/S0140-6736(21)01961-9","article-title":"Disease pathology in fibrotic interstitial lung disease: is it all about usual interstitial pneumonia?","volume":"398","author":"EA Renzoni","year":"2021","journal-title":"Lancet"},{"key":"pone.0333070.ref021","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ebiom.2019.10.050","article-title":"Endotype-phenotyping may predict a treatment response in progressive fibrosing interstitial lung disease","volume":"50","author":"A-M Hoffmann-Vold","year":"2019","journal-title":"EBioMedicine"},{"issue":"12","key":"pone.0333070.ref022","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/s41584-019-0322-7","article-title":"Shared and distinct mechanisms of fibrosis","volume":"15","author":"JHW Distler","year":"2019","journal-title":"Nat Rev Rheumatol"},{"issue":"10","key":"pone.0333070.ref023","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1093\/rheumatology\/keae076","article-title":"Lung imaging patterns in connective tissue disease-associated interstitial lung disease impact prognosis and immunosuppression response","volume":"63","author":"B Zheng","year":"2024","journal-title":"Rheumatology (Oxford)"},{"issue":"16","key":"pone.0333070.ref024","doi-asserted-by":"crossref","first-page":"8952","DOI":"10.3390\/ijms22168952","article-title":"Fibrotic idiopathic interstitial lung disease: the molecular and cellular key players","volume":"22","author":"AV Samarelli","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"9842","key":"pone.0333070.ref025","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0140-6736(12)61079-4","article-title":"Interstitial lung disease in connective tissue disorders","volume":"380","author":"A Fischer","year":"2012","journal-title":"Lancet"},{"key":"pone.0333070.ref026","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.3389\/fimmu.2019.01327","article-title":"Pulmonary manifestations of primary Sj\u00f6gren\u2019s syndrome: underlying immunological mechanisms, clinical presentation, and management","volume":"10","author":"S Gupta","year":"2019","journal-title":"Front Immunol"},{"issue":"2","key":"pone.0333070.ref027","doi-asserted-by":"crossref","first-page":"102447","DOI":"10.1016\/j.autrev.2019.102447","article-title":"Clinical, morphological features and prognostic factors associated with interstitial lung disease in primary Sj\u04e7gren\u2019s syndrome: a systematic review from the Italian Society of Rheumatology","volume":"19","author":"G Sambataro","year":"2020","journal-title":"Autoimmun Rev"},{"issue":"1","key":"pone.0333070.ref028","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene expression omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"R Edgar","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"pone.0333070.ref029","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"P Langfelder","year":"2008","journal-title":"BMC Bioinformatics"},{"issue":"10082","key":"pone.0333070.ref030","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1016\/S0140-6736(17)30866-8","article-title":"Idiopathic pulmonary fibrosis","volume":"389","author":"L Richeldi","year":"2017","journal-title":"Lancet"},{"key":"pone.0333070.ref031","doi-asserted-by":"crossref","first-page":"105635","DOI":"10.1016\/j.phrs.2021.105635","article-title":"New insights into the Hippo\/YAP pathway in idiopathic pulmonary fibrosis","volume":"169","author":"M Sun","year":"2021","journal-title":"Pharmacol Res"},{"key":"pone.0333070.ref032","doi-asserted-by":"crossref","first-page":"1337317","DOI":"10.3389\/fpsyt.2024.1337317","article-title":"Perceived social support, perceived stress, and quality of sleep among COVID-19 patients in Iran: assessing measurement invariance of the multidimensional scale of perceived social support across gender and age","volume":"15","author":"M Habibi Asgarabad","year":"2024","journal-title":"Front Psychiatry"},{"key":"pone.0333070.ref033","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3389\/fpsyg.2020.00537","article-title":"Factor structure of the 10-item perceived stress scale and measurement invariance across genders among Chinese adolescents","volume":"11","author":"X Liu","year":"2020","journal-title":"Front Psychol"},{"issue":"22","key":"pone.0333070.ref034","doi-asserted-by":"crossref","first-page":"8733","DOI":"10.3390\/ijms21228733","article-title":"Connection between the gut microbiome, systemic inflammation, gut permeability and FOXP3 expression in patients with primary Sj\u00f6gren\u2019s syndrome","volume":"21","author":"A Cano-Ortiz","year":"2020","journal-title":"Int J Mol Sci"},{"key":"pone.0333070.ref035","doi-asserted-by":"crossref","first-page":"16148","DOI":"10.1038\/srep16148","article-title":"The effect of short-chain fatty acids on human monocyte-derived dendritic cells","volume":"5","author":"C Nastasi","year":"2015","journal-title":"Sci Rep"},{"issue":"4","key":"pone.0333070.ref036","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/mi.2016.114","article-title":"Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43","volume":"10","author":"W Wu","year":"2017","journal-title":"Mucosal Immunol"},{"issue":"6","key":"pone.0333070.ref037","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.7150\/ijbs.92514","article-title":"CYSLTR1 antagonist inhibits Th17 cell differentiation by regulating the NF-\u03baB signaling for the treatment of psoriasis","volume":"20","author":"J Zhao","year":"2024","journal-title":"Int J Biol Sci"},{"issue":"1","key":"pone.0333070.ref038","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/hep.32787","article-title":"Combinatorial targeting of G-protein-coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug-induced liver injury","volume":"78","author":"M Biagioli","year":"2023","journal-title":"Hepatology"},{"issue":"7769","key":"pone.0333070.ref039","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/s41586-019-1456-0","article-title":"CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy","volume":"572","author":"AA Barkal","year":"2019","journal-title":"Nature"},{"key":"pone.0333070.ref040","doi-asserted-by":"crossref","first-page":"997","DOI":"10.15212\/bioi-2023-0022","article-title":"Targeting the CD24-Siglec10 axis: a potential strategy for cancer immunotherapy","volume":"5","author":"J Fang","year":"2024","journal-title":"BIO Integration"},{"issue":"11","key":"pone.0333070.ref041","article-title":"Targeting myeloid checkpoint Siglec-10 reactivates antitumor immunity and improves anti-programmed cell death 1 efficacy in gastric cancer","volume":"11","author":"K Lv","year":"2023","journal-title":"J Immunother Cancer"},{"issue":"4","key":"pone.0333070.ref042","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1007\/s11684-021-0868-z","article-title":"Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient samples","volume":"16","author":"C Zhang","year":"2022","journal-title":"Front Med"},{"key":"pone.0333070.ref043","doi-asserted-by":"crossref","first-page":"108403","DOI":"10.1016\/j.intimp.2021.108403","article-title":"Elevated CD19 Siglec-10 B cell levels are correlated with systemic lupus erythematosus disease activity","volume":"102","author":"B Ju","year":"2022","journal-title":"Int Immunopharmacol"},{"issue":"23","key":"pone.0333070.ref044","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.163030","article-title":"A randomized, phase II study of sequential belimumab and rituximab in primary Sj\u00f6gren\u2019s syndrome","volume":"7","author":"X Mariette","year":"2022","journal-title":"JCI Insight"},{"issue":"12","key":"pone.0333070.ref045","first-page":"2369","article-title":"The role of imbalanced CD226\/TIGIT on activated peripheral double-negative T cells in the pathogenesis of primary Sj\u00f6gren\u2019s syndrome","volume":"42","author":"C Deng","year":"2024","journal-title":"Clin Exp Rheumatol"},{"issue":"2","key":"pone.0333070.ref046","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/art.42683","article-title":"Multimodal single-cell sequencing of B cells in primary Sj\u00f6gren\u2019s syndrome","volume":"76","author":"G Arvidsson","year":"2024","journal-title":"Arthritis Rheumatol"},{"issue":"1","key":"pone.0333070.ref047","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s10238-024-01429-6","article-title":"Immunometabolic alteration of CD4+ T cells in the pathogenesis of primary Sj\u00f6gren\u2019s syndrome","volume":"24","author":"Y Chen","year":"2024","journal-title":"Clin Exp Med"},{"issue":"12","key":"pone.0333070.ref048","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3002943","article-title":"Multiomic profiling of chronically activated CD4+ T cells identifies drivers of exhaustion and metabolic reprogramming","volume":"22","author":"ML Lawton","year":"2024","journal-title":"PLoS Biol"},{"issue":"1","key":"pone.0333070.ref049","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/s41420-024-01889-5","article-title":"B cell memory: from generation to reactivation: a multipronged defense wall against pathogens","volume":"10","author":"MZ Syeda","year":"2024","journal-title":"Cell Death Discov"},{"issue":"10","key":"pone.0333070.ref050","doi-asserted-by":"crossref","first-page":"107943","DOI":"10.1016\/j.isci.2023.107943","article-title":"Single-cell transcriptome profiling reveals immune and stromal cell heterogeneity in primary Sj\u00f6gren\u2019s syndrome","volume":"26","author":"N Xiang","year":"2023","journal-title":"iScience"},{"issue":"1","key":"pone.0333070.ref051","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s13073-020-00773-y","article-title":"FOXC1-mediated LINC00301 facilitates tumor progression and triggers an immune-suppressing microenvironment in non-small cell lung cancer by regulating the HIF1\u03b1 pathway","volume":"12","author":"CC Sun","year":"2020","journal-title":"Genome Med"},{"issue":"2","key":"pone.0333070.ref052","first-page":"229","article-title":"miR-27a-3p inhibited synthesis of Col \u2160 and Col \u2162 in pulmonary fibroblasts through Wnt3a\/ \u03b2-catenin signaling pathway","volume":"35","author":"L Liu","year":"2019","journal-title":"Chinese Pharmacol Bull"},{"key":"pone.0333070.ref053","first-page":"7415909","article-title":"MicroRNA biomarker hsa-miR-195-5p for detecting the risk of lung cancer","volume":"2020","author":"L Li","year":"2020","journal-title":"Int J Genomics"},{"issue":"8","key":"pone.0333070.ref054","doi-asserted-by":"crossref","first-page":"4793","DOI":"10.1007\/s12010-023-04777-3","article-title":"Hsa-miR-15b-5p\/miR-195-5p controls osteogenic differentiation of human adipose-derived mesenchymal stem cells through regulating indian hedgehog expression","volume":"196","author":"S Harimi","year":"2024","journal-title":"Appl Biochem Biotechnol"},{"key":"pone.0333070.ref055","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.abb.2016.02.003","article-title":"MicroRNA-26a-5p regulates the expression of inducible nitric oxide synthase via activation of NF-\u03baB pathway in human osteoarthritis chondrocytes","volume":"594","author":"Z Rasheed","year":"2016","journal-title":"Arch Biochem Biophys"},{"issue":"7","key":"pone.0333070.ref056","first-page":"673","article-title":"A study on mechanism of lncRNA-mediated SNHG5\/miR-26a-5p\/MTDH signal axis promoting metastasis of colorectal cancer","volume":"33","author":"J Ye","year":"2023","journal-title":"Chinese J Cancer Res"},{"issue":"5","key":"pone.0333070.ref057","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/s10787-019-00618-0","article-title":"Cysteinyl leukotriene receptor antagonism: a promising pharmacological strategy for lowering the severity of arthritis","volume":"27","author":"N Venugopal","year":"2019","journal-title":"Inflammopharmacology"},{"key":"pone.0333070.ref058","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.intimp.2018.04.042","article-title":"Montelukast inhibits inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes","volume":"61","author":"H Dong","year":"2018","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"pone.0333070.ref059","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/imm.13308","article-title":"Montelukast alleviates inflammation in experimental autoimmune encephalomyelitis by altering Th17 differentiation in a mouse model","volume":"163","author":"B Han","year":"2021","journal-title":"Immunology"}],"container-title":["PLOS One"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0333070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T17:25:10Z","timestamp":1759771510000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0333070"}},"subtitle":[],"editor":[{"given":"Yoshiaki","family":"Zaizen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,10,6]]},"references-count":59,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0333070","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,6]]}}}