{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T11:30:44Z","timestamp":1781523044355,"version":"3.54.1"},"reference-count":69,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Education and Scientific Research Project for Young and Middle-aged Teachers of Fuijan Province","award":["JAT251339"],"award-info":[{"award-number":["JAT251339"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Triclosan (TCS) is an artificially synthesized broad-spectrum antimicrobial agent, which is widely used in personal care products. It is a new endocrine disruptor and has potential health hazards to human body.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Based on network toxicology and molecular docking technology, the compounds that may cause hepatotoxicity in triclosan were predicted and the mechanism was discussed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>From April to May 2025, the targets of triclosan were identified using databases such as STITCH, CTD, Swiss Target Prediction, and TargetNet. Additionally, gene targets associated with liver toxicity were identified from the GeneCards and OMIM databases. The intersection of triclosan-targets and liver toxicity-related gene targets was used to identify candidate targets. Using the String platform, a protein interaction network was constructed for these candidate targets to identify core functional modules within the network. The candidate targets were analyzed for GO and KEGG enrichment using DAVID, and a triclosan-liver toxicity-target pathway network was constructed using Cytoscape 3.10.1 software. Network topology analysis was conducted to screen for key components and targets. Finally, molecular docking was performed on the core targets using CB-Dock2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      683 candidate targets for liver toxicity caused by triclosan were identified. The core targets for liver toxicity from triclosan production include\n                      <jats:italic>TP53, EGFR, AKT1, IL6, JUN,<\/jats:italic>\n                      and\n                      <jats:italic>FN1<\/jats:italic>\n                      . Molecular docking analysis shows that the binding free energy of triclosan with these core targets is less than \u22125.5 kcal\/mol. The comprehensive analysis results showed that the liver damage caused by triclosan was mainly related to the activation of Pathways in cancer, Endocrine resistance, AGE-RAGE signaling pathway in diabetic complications, hepatitis B, and lipid and atherosclerosis signaling pathways.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec005\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The potential targets and molecular mechanisms of triclosan (TCS) induced liver injury were investigated, and 6 key targets and 5 pathways were identified, providing a new paradigm for evaluating the health risks caused by environmental pollutants.<\/jats:p>\n                  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Peng","year":"2024","journal-title":"Ecotoxicol Environ Saf"},{"issue":"11","key":"pone.0333244.ref025","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1007\/s00204-018-2308-7","article-title":"Role of peroxisome proliferator-activated receptor alpha (PPAR\u03b1) and PPAR\u03b1-mediated species differences in triclosan-induced liver toxicity","volume":"92","author":"Y Tang","year":"2018","journal-title":"Arch Toxicol"},{"key":"pone.0333244.ref026","doi-asserted-by":"crossref","first-page":"145285","DOI":"10.1016\/j.scitotenv.2021.145285","article-title":"Triclosan-induced abnormal expression of miR-30b regulates fto-mediated m6A methylation level to cause lipid metabolism disorder in zebrafish","volume":"770","author":"L Sun","year":"2021","journal-title":"Sci Total Environ"},{"key":"pone.0333244.ref027","doi-asserted-by":"crossref","first-page":"125086","DOI":"10.1016\/j.chemosphere.2019.125086","article-title":"Triclosan-induced liver and brain injury in zebrafish (Danio 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Manage"},{"key":"pone.0333244.ref035","doi-asserted-by":"crossref","first-page":"136835","DOI":"10.1016\/j.jhazmat.2024.136835","article-title":"Pesticide exposures and 10-year atherosclerotic cardiovascular disease risk: Integrated epidemiological and bioinformatics analysis","volume":"485","author":"X Wu","year":"2025","journal-title":"J Hazard Mater"},{"key":"pone.0333244.ref036","doi-asserted-by":"crossref","first-page":"136999","DOI":"10.1016\/j.jhazmat.2024.136999","article-title":"Integration of network toxicology and transcriptomics reveals the novel neurotoxic mechanisms of 2, 2\u2019, 4, 4\u2019-tetrabromodiphenyl ether","volume":"486","author":"T Qu","year":"2025","journal-title":"J Hazard Mater"},{"issue":"1","key":"pone.0333244.ref037","doi-asserted-by":"crossref","first-page":"22894","DOI":"10.1038\/s41598-023-48446-1","article-title":"Bioinformatics analysis of hub genes as osteoarthritis prognostic biomarkers","volume":"13","author":"J Zeng","year":"2023","journal-title":"Sci Rep"},{"key":"pone.0333244.ref038","article-title":"CB-Dock2: improved protein-ligand blind docking by integrating cavity detection, docking and homologous template fitting","volume":"50","author":"Y Liu","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"pone.0333244.ref039","article-title":"NCBI GEO: archive for functional genomics data sets--update","volume":"41","author":"T Barrett","year":"2013","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"pone.0333244.ref040","first-page":"160","article-title":"Oncogenes and tumor suppressor genes","volume":"44","author":"RA Weinberg","year":"1994","journal-title":"CA Cancer J Clin"},{"issue":"1","key":"pone.0333244.ref041","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of Cancer: New Dimensions","volume":"12","author":"D Hanahan","year":"2022","journal-title":"Cancer Discov"},{"issue":"3","key":"pone.0333244.ref042","doi-asserted-by":"crossref","first-page":"512","DOI":"10.3390\/cells12030512","article-title":"The Role of TP53 in Adaptation and Evolution","volume":"12","author":"K Voskarides","year":"2023","journal-title":"Cells"},{"key":"pone.0333244.ref043","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1101\/gad.340976.120","article-title":"p53 tetramerization: at the center of the dominant-negative effect of mutant p53","volume":"34","author":"J Gencel-Augusto","year":"2020","journal-title":"Genes Dev"},{"issue":"12","key":"pone.0333244.ref044","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202153085","article-title":"Adaptive homeostasis and the p53 isoform network","volume":"22","author":"S Mehta","year":"2021","journal-title":"EMBO Rep"},{"issue":"6","key":"pone.0333244.ref045","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.ccell.2024.04.009","article-title":"Understanding the complexity of p53 in a new era of tumor suppression","volume":"42","author":"Y Liu","year":"2024","journal-title":"Cancer Cell"},{"key":"pone.0333244.ref046","doi-asserted-by":"crossref","first-page":"593383","DOI":"10.3389\/fonc.2020.593383","article-title":"Heterogeneity of TP53 Mutations and P53 Protein Residual Function in Cancer: Does It Matter?","volume":"10","author":"P Monti","year":"2020","journal-title":"Front Oncol"},{"issue":"7","key":"pone.0333244.ref047","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/jmcb\/mjz060","article-title":"p53 modifications: exquisite decorations of the powerful guardian","volume":"11","author":"Y Liu","year":"2019","journal-title":"J Mol Cell Biol"},{"issue":"28","key":"pone.0333244.ref048","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.1038\/onc.2016.502","article-title":"Census and evaluation of p53 target genes","volume":"36","author":"M Fischer","year":"2017","journal-title":"Oncogene"},{"key":"pone.0333244.ref049","doi-asserted-by":"crossref","first-page":"810344","DOI":"10.3389\/fphar.2022.810344","article-title":"Assessment of the Potential of Sarcandra glabra (Thunb.) Nakai. in Treating Ethanol-Induced Gastric Ulcer in Rats Based on Metabolomics and Network Analysis","volume":"13","author":"C Li","year":"2022","journal-title":"Front Pharmacol"},{"issue":"1","key":"pone.0333244.ref050","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1186\/s12935-021-02396-8","article-title":"p53 signaling in cancer progression and therapy","volume":"21","author":"HE Marei","year":"2021","journal-title":"Cancer Cell Int"},{"issue":"3","key":"pone.0333244.ref051","doi-asserted-by":"crossref","first-page":"105707","DOI":"10.1016\/j.jbc.2024.105707","article-title":"The P53-P21-RB1 pathway promotes BRD4 degradation in liver cancer through USP1","volume":"300","author":"N Li","year":"2024","journal-title":"J Biol Chem"},{"issue":"4","key":"pone.0333244.ref052","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2013-14-4-r32","article-title":"p53 induces transcriptional and translational programs to suppress cell proliferation and growth","volume":"14","author":"F Loayza-Puch","year":"2013","journal-title":"Genome Biol"},{"issue":"42","key":"pone.0333244.ref053","doi-asserted-by":"crossref","first-page":"15155","DOI":"10.1073\/pnas.1417549111","article-title":"Loss of p53 induces cell proliferation via Ras-independent activation of the Raf\/Mek\/Erk signaling pathway","volume":"111","author":"M Drosten","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"pone.0333244.ref054","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1007\/s11033-024-09865-z","article-title":"EGFR mutations and abnormal trafficking in cancers","volume":"51","author":"X Kang","year":"2024","journal-title":"Mol Biol Rep"},{"issue":"190","key":"pone.0333244.ref055","doi-asserted-by":"crossref","first-page":"20220088","DOI":"10.1098\/rsif.2022.0088","article-title":"Critical roles for EGFR and EGFR-HER2 clusters in EGF binding of SW620 human carcinoma cells","volume":"19","author":"AJM Wollman","year":"2022","journal-title":"J R Soc Interface"},{"issue":"22","key":"pone.0333244.ref056","doi-asserted-by":"crossref","first-page":"5432","DOI":"10.1128\/MCB.00742-10","article-title":"Structural evidence for loose linkage between ligand binding and kinase activation in the epidermal growth factor receptor","volume":"30","author":"C Lu","year":"2010","journal-title":"Mol Cell Biol"},{"issue":"2","key":"pone.0333244.ref057","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s13353-022-00690-3","article-title":"TGF\u03b1-EGFR pathway in breast carcinogenesis, association with WWOX expression and estrogen activation","volume":"63","author":"K Pospiech","year":"2022","journal-title":"J Appl Genet"},{"issue":"6","key":"pone.0333244.ref058","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0092-8674(02)00940-6","article-title":"Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha","volume":"110","author":"TPJ Garrett","year":"2002","journal-title":"Cell"},{"issue":"1","key":"pone.0333244.ref059","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.gendis.2019.11.003","article-title":"The Hippo Tumor Suppressor Pathway (YAP\/TAZ\/TEAD\/MST\/LATS) and EGFR-RAS-RAF-MEK in Cancer Metastasis","volume":"8","author":"MR Zinatizadeh","year":"2019","journal-title":"Genes Dis"},{"issue":"12","key":"pone.0333244.ref060","doi-asserted-by":"crossref","first-page":"4850","DOI":"10.3390\/molecules28124850","article-title":"Identification of Potent Inhibitors Targeting EGFR and HER3 for Effective Treatment of Chemoresistance in Non-Small Cell Lung Cancer","volume":"28","author":"Areeba","year":"2023","journal-title":"Molecules"},{"issue":"1","key":"pone.0333244.ref061","doi-asserted-by":"crossref","first-page":"8675","DOI":"10.1038\/s41598-021-88134-6","article-title":"EGFR-dependent tyrosine phosphorylation of integrin \u03b24 is not required for downstream signaling events in cancer cell 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