{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T18:02:14Z","timestamp":1773424934578,"version":"3.50.1"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["89490323"],"award-info":[{"award-number":["89490323"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["89490323"],"award-info":[{"award-number":["89490323"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000061","name":"Fogarty International Center","doi-asserted-by":"publisher","award":["D43TW010526"],"award-info":[{"award-number":["D43TW010526"]}],"id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Respiratory syncytial virus is an important cause of acute respiratory illness in older adults, yet data from sub-Saharan Africa remain scarce. Better understanding of its prevalence, coinfections, seasonal patterns, and risk factors in older populations is essential for strengthening surveillance systems and informing prevention strategies in low-resource settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cross-sectional study using Uganda\u2019s national influenza-like illness and severe acute respiratory infection sentinel surveillance data from December 2010 to January 2025. Adults aged \u226565 years with real-time-PCR results for respiratory syncytial virus, influenza A and B, and SARS-CoV-2 were included. Descriptive analyses summarized prevalence, clinical characteristics, and temporal trends. Poisson regression with robust variance estimated adjusted prevalence ratios for factors associated with infection and hospitalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 545 illness episodes (mean age 73.2 years; 54.1% female), the period prevalence of respiratory syncytial virus across 2010\u20132025 was 4.8% (95% CI 3.3\u20136.9), comparable to influenza A (4.2%) and lower than SARS-CoV-2 (6.4%). Most RSV cases were mono-infections (92.3%), with rare respiratory syncytial virus\u2013influenza coinfections (0.4%) and no respiratory syncytial virus\u2013SARS-CoV-2 coinfections. Asthma and pneumonia were independent predictors of infection. Hospitalization was strongly associated with asthma, pneumonia, and heart disease. Activity showed seasonal peaks in March and June, with a marked decline during 2020\u20132021 and resurgence thereafter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RSV is a consistent contributor to medically attended respiratory illness among older Ugandan adults, with prevalence similar to influenza A. Although strong associations with asthma and pneumonia were observed, asthma-related findings are based on few cases and should be considered hypothesis-generating. Seasonal clustering and post-pandemic resurgence support integrating respiratory syncytial virus into routine respiratory surveillance and inform the targeted introduction of preventive interventions, including vaccination, in low- and middle-income settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0333329","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:23:51Z","timestamp":1773422631000},"page":"e0333329","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Respiratory syncytial virus burden among Ugandan adults aged \u226565 years: A 15-year sentinel surveillance study of prevalence, coinfections, and comorbidities (2010\u20132025)"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3964-2169","authenticated-orcid":true,"given":"Haruna","family":"Muwonge","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9427-9334","authenticated-orcid":true,"given":"Joyce","family":"Namulondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levicatus","family":"Mugenyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joweria","family":"Nakaseegu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bridget","family":"Nakamoga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Amwine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roselyne","family":"Akugizibwe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9844-4245","authenticated-orcid":true,"given":"Abdul","family":"Ssekandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Ssaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Kasujja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6963-7892","authenticated-orcid":true,"given":"Godfrey 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