{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:13:50Z","timestamp":1789017230101,"version":"build-2803163510"},"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Zhejiang Medical Association Clinical Research Fund","award":["2022ZYC-Z13"],"award-info":[{"award-number":["2022ZYC-Z13"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Chronic atrophic gastritis (CAG) is a prevalent condition that can undergo precancerous lesions of gastric cancer (PLGC) and thus progression to gastric cancer. Weifuchun (WFC), a traditional Chinese herbal compound, is employed in CAG treatment and microbial homeostasis modulation. We aimed to explore the role of WFC in CAG from the perspective of gastrointestinal microbiota.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PLGC rats were developed by N-methyl-N\u2019-nitro-N-nitrosoguanidine treatment. Then, various doses of WFC were administered to the rats and WFC compositions were analyzed. The pathological changes and inflammatory markers of the rats were assessed. Key proteins in the interleukin (IL)-6\/Janus Kinase 1\/Signal Transducer and Activator of Transcription 3 (JAK1\/STAT3) pathway were evaluated, alongside fecal microbial analysis through 16S ribosomal DNA sequencing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Most compounds identified from WFC were nucleosides, flavones, organic acids, phenylpropanoids and other components. WFC treatment alleviated intestinal metaplasia and dysplasia caused by atrophic gastritis in PLGC rats. WFC also reduced inflammatory marker levels, and inhibited the IL-6\/JAK1\/STAT3 pathway for PLGC rats. The higher the dose of WFC was administrated, the better the effects on the aforementioned results. Simultaneously, WFC improved the CAG gastrointestinal microbiota homeostasis. Interestingly, WFC increased\n                      <jats:italic>Coprocuccus<\/jats:italic>\n                      abundance, which was significantly correlated with proliferating cell nuclear antigen and IL-6 levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>WFC alleviated PLGC by regulating the balance of gastrointestinal microbiota and influencing the IL-6\/JAK1\/STAT3 pathway, revealing the potential connection between gastrointestinal microbiota and CAG progression. This study is the first to link gastrointestinal microbiota homeostasis and IL-6\/JAK1\/STAT3 pathway, providing novel insights into WFC\u2019s multi-targeted therapeutic mechanism on CAG.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0333375","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T18:21:31Z","timestamp":1764008491000},"page":"e0333375","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Weifuchun alleviates MNNG-induced chronic atrophic gastritis by improving the gastric and intestinal microbiota homeostasis"],"prefix":"10.1371","volume":"20","author":[{"given":"Yingying","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlan","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaojiao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4704-6642","authenticated-orcid":true,"given":"Shenbao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"issue":"3","key":"pone.0333375.ref001","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"F Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"pone.0333375.ref002","doi-asserted-by":"crossref","first-page":"9925561","DOI":"10.1155\/2021\/9925561","article-title":"Astragaloside IV Alleviates Cerebral Ischemia-Reperfusion Injury through NLRP3 Inflammasome-Mediated Pyroptosis Inhibition via Activating Nrf2","volume":"2021","author":"L Xiao","year":"2021","journal-title":"Oxid Med Cell Longev"},{"issue":"4","key":"pone.0333375.ref003","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1053\/j.gastro.2008.01.071","article-title":"Gastric cancer risk in patients with premalignant gastric lesions: a nationwide cohort study in the Netherlands","volume":"134","author":"AC de Vries","year":"2008","journal-title":"Gastroenterology"},{"issue":"8","key":"pone.0333375.ref004","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/ajg.2016.188","article-title":"Risks and Predictors of Gastric Adenocarcinoma in Patients with Gastric Intestinal Metaplasia and Dysplasia: A Population-Based Study","volume":"111","author":"D Li","year":"2016","journal-title":"Am J Gastroenterol"},{"issue":"12","key":"pone.0333375.ref005","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1016\/j.dld.2019.09.016","article-title":"Chronic atrophic gastritis: Natural history, diagnosis and therapeutic management. 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