{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T18:44:16Z","timestamp":1762541056225,"version":"build-2065373602"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006044","name":"Astellas Pharma Europe Ltd.","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006044","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Survival rates in the European population with gastric and gastroesophageal junction (G\/GEJ) adenocarcinoma remain low. Epidemiologic research is warranted to understand the population size, unmet need, and current treatment patterns of G\/GEJ adenocarcinoma. The objective of this research was to develop an algorithm to link patients across the FRench EsoGAstric Tumours (FREGAT) and Syst\u00e8me National des Donn\u00e9es de Sant\u00e9 (SNDS) databases to develop a real-world dataset for G\/GEJ adenocarcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A step-by-step, indirect, deterministic record linkage algorithm was developed to match patient records from the FREGAT and SNDS databases. Corresponding variables in each data source were matched at an individual level. Each step in the linkage process used a given scoring criterion; the linkage process proceeded until a unique pair of patient records had equal observations across the databases, at which time patient data were considered linked. Due to the large number of potential matches, the linkage process was performed in two parts: first, matching on the stratified population using individual corresponding variables, and second, by linking without any stratification. Descriptive and inferential statistics were used to assess validity of the linkage process. This study was approved by the National Expertise Committee (Ethical and Scientific Committee for Research, Studies and Evaluations in the Field of Health; 5758940) and the French Personal Data Protection Agency (CNIL; 92 1441\/DR 2022 088).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 1617 patients included in the FREGAT database, 1385 (85.7%) were successfully linked to the SNDS database. A majority of the linked patients (1159 [83.7%] of 1385) were matched in the first part of the linkage process.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We established an algorithm that enabled linkage of the FREGAT and SNDS databases that may be applied to capture additional data related to G\/GEJ adenocarcinoma in France.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0333667","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T18:40:48Z","timestamp":1762540848000},"page":"e0333667","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Methodological approach to optimize a step-by-step deterministic linkage of SNDS data with a clinical database (FREGAT) of gastric\/gastroesophageal junction adenocarcinoma in France: Pitfalls and learnings"],"prefix":"10.1371","volume":"20","author":[{"given":"Magali","family":"Laborey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8712-8813","authenticated-orcid":true,"given":"Audrey","family":"Lajoinie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonatan","family":"Freilich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuelle","family":"Samalin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8284-3743","authenticated-orcid":true,"given":"Olivier","family":"Bouch\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Piessen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Stoelzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Chilelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,11,7]]},"reference":[{"issue":"15","key":"pone.0333667.ref001","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1016\/j.ejca.2015.08.001","article-title":"The 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