{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T03:18:59Z","timestamp":1779160739159,"version":"3.51.4"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scientific Research Project from the Health Commission of Nantong","award":["MSZ2024060"],"award-info":[{"award-number":["MSZ2024060"]}]},{"DOI":"10.13039\/501100006258","name":"Comisi\u00c3\u00b3n de Investigaciones Cient\u00c3ficas","doi-asserted-by":"publisher","award":["MSZ2023047"],"award-info":[{"award-number":["MSZ2023047"]}],"id":[{"id":"10.13039\/501100006258","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Beijing Liver and Gallbladder Mutual-Aid Foundation Research Project","award":["RGG102"],"award-info":[{"award-number":["RGG102"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Non-pulmonary sepsis often induces Acute Respiratory Distress Syndrome (ARDS). Dysregulated inflammation and coagulation disorders play important roles in the development of non-pulmonary sepsis-associated ARDS (NPS-ARDS). Heparin, with its potential anticoagulant and anti-inflammatory properties, may be used in the treatment of NPS-ARDS.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>This is a retrospective observational study that uses Structured Query Language (SQL) to extract clinical data of NPS-ARDS patients from the Medical Information Mart for Intensive Care (MIMIC)-IV database. Based on the dosage of heparin, patients were divided into three groups: low-dose heparin treatment group (0-5000u\/d), medium-dose heparin treatment group (5000u-10000u\/d), and high-dose heparin treatment group (greater than 10000u\/d). Propensity score matching (1:1) was used to match similar patients from the NPS-ARDS patients who did not use heparin to each heparin treatment group. The study compares the effects of heparin at different dosages on short-term mortality (7-day, 28-day, and 60-day mortality) and one-year cumulative survival rate in NPS-ARDS patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>PSM reduced the impact of confounding factors on the results to some extent. Low and medium doses of heparin did not improve patient mortality. However, high-dose heparin improved the short-term mortality of NPS-ARDS patients (7-day mortality: 4.1% vs. 14.3%, P\u2009&lt;\u20090.001; 28-day mortality: 9.4% vs. 22.6%, P\u2009&lt;\u20090.001; 60-day mortality: 13.2% vs. 24.8%, P\u2009=\u20090.001) and one-year cumulative survival rate (Log Rank\u2009=\u20098.349, P\u2009=\u20090.004), but it also prolonged ICU stay (6.7\u2009\u00b1\u20096.2 days vs. 5.7\u2009\u00b1\u20094.8 days, P\u2009=\u20090.041) and invasive mechanical ventilation (11.7\u2009\u00b1\u20096.9 hours\/day vs. 5.7\u2009\u00b1\u20094.8 hours\/day, P\u2009&lt;\u20090.001).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>In patients with NPS-ARDS, high-dose heparin was associated with significantly improved short- and long-term survival, albeit at the cost of prolonged ICU stay and mechanical ventilation.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0333795","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T17:34:46Z","timestamp":1760117686000},"page":"e0333795","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Heparin improves the mortality of patients with non-pulmonary sepsis-associated ARDS: A MIMIC-IV database analysis based on propensity score 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