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A new nodal resistance <jats:italic><jats:italic>R<\/jats:italic><\/jats:italic><jats:sub><jats:italic>ne<\/jats:italic><\/jats:sub> between the axonal membrane and extracellular fluid was introduced into the century old cable theory. Later, a direct and careful measurement of ulnar NCV across a 10\u2009cm segment around the elbow by another publication appeared to support the suggestion of increased NCV with stretch. However, in order to eliminate the possibility of slacks of ulnar nerve in the upper arm affecting the measurements, the present work was taken up on a shorter 5\u2009cm segment which again supported the suggestion, increasing confidence in the <jats:italic><jats:italic>R<\/jats:italic><\/jats:italic><jats:sub><jats:italic>ne<\/jats:italic><\/jats:sub> hypothesis. Furthermore, wrist flexion or extension was also observed to affect the ulnar NCV at the elbow to some extent, revealing a new phenomenon. While attempting to formulate an analytical treatment of <jats:italic><jats:italic>R<\/jats:italic><\/jats:italic><jats:sub><jats:italic>ne<\/jats:italic><\/jats:sub>, the earlier work found it very challenging as the physical structure was extremely complex. Proposing an alternative physical model to simulate the variation in <jats:italic><jats:italic>R<\/jats:italic><\/jats:italic><jats:sub><jats:italic>ne<\/jats:italic><\/jats:sub> suggested earlier, the current study presents an analytical treatment that relates <jats:italic><jats:italic>R<\/jats:italic><\/jats:italic><jats:sub><jats:italic>ne<\/jats:italic><\/jats:sub> and a corresponding effective resistivity value to increases in stretch, and relates these quantitatively to stretch values based on the measured values of NCV. This then provided the basis of a quantitative analysis which could be useful for future research. While appreciating that other microstructures in the node at or near the axonal membrane may also contribute to the observed anomaly, but lack of direct experimental evidence related to nerve stretch tends to weigh more on the <jats:italic><jats:italic>R<\/jats:italic><\/jats:italic><jats:sub><jats:italic>ne<\/jats:italic><\/jats:sub> hypothesis in explaining the anomaly.<\/jats:p>","DOI":"10.1371\/journal.pone.0333925","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T17:31:43Z","timestamp":1760117503000},"page":"e0333925","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of stretch on conduction in myelinated nerve due to wrist movement: An experimental and analytical study"],"prefix":"10.1371","volume":"20","author":[{"given":"Sabrina","family":"Sharmin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5288-2357","authenticated-orcid":true,"given":"Mohammad Abu Sayem","family":"Karal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaid Bin","family":"Mahbub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1373-7920","authenticated-orcid":true,"given":"Khondkar Siddique-e","family":"Rabbani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"key":"pone.0333925.ref001","unstructured":"Rahman MM. 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