{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:43:23Z","timestamp":1792806203092,"version":"4.5.0"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009331","name":"Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support","doi-asserted-by":"crossref","award":["ZLRK202510"],"award-info":[{"award-number":["ZLRK202510"]}],"id":[{"id":"10.13039\/501100009331","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Beijing Hospitals Authority Youth Program","award":["QML20230510"],"award-info":[{"award-number":["QML20230510"]}]},{"name":"the Capital Development Research Fund Project","award":["2024-2-2047"],"award-info":[{"award-number":["2024-2-2047"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"\n Objective<\/jats:title>\n Postoperative delirium is a common complication after neurosurgery. The association between intraoperative hypotension and postoperative delirium in the neurosurgical population is unknown.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n This is a secondary analysis of a randomized controlled study<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Adults scheduled for elective craniotomy under general anesthesia were included in 1 study center.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n Of 260 patients, a total of 240 participants are included for final analysis after excluding patients without intraoperative blood pressure data.<\/jats:p>\n <\/jats:sec>\n \n The primary outcome measures<\/jats:title>\n The primary outcome was the occurrence of delirium within the first 5 postoperative days, assessed with the Confusion Assessment Method or a 3-minute Diagnostic interview for the Confusion Assessment Method.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n A total of 240 patients were included (median age, 45 years), and 83(35%) patients experienced postoperative delirium. Curves of lowest mean arterial pressure versus stroke incidence suggested a threshold at 65 mmHg. There was no association between duration below 65\u2009mm Hg and postoperative delirium (odds ratio, 1.01; 95% confidence interval, 0.96, 1.06). The odds ratio for duration below 65\u2009mm Hg for 10 minutes was 1.03 (95% confidence interval, 0.97, 1.09) adjusted by history of hypertension, age\u2009>\u200945 yr, tumor volume, tumor type of glioma, preoperative Mini-Mental State Examination (MMSE) >26, and dexmedetomidine infusion which were all indicated the independent risk factors for delirium.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The current results could not indicate intraoperative hypotension of mean arterial pressure lower than 65 mmHg associated with delirium after frontotemporal brain tumor resection.<\/jats:p>\n <\/jats:sec>\n \n Trial registration<\/jats:title>\n ClinicalTrials.gov NCT04674241<\/jats:p>\n 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