{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:38:49Z","timestamp":1788863929138,"version":"build-2803163510"},"reference-count":66,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007861","name":"University of Gondar","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007861","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>Peptic ulcer disease affects 10% of the global population, and current treatments have limitations. Vicia faba seeds are traditionally used in Ethiopia for gastric ulcers and gastritis, but scientific evidence is lacking. Seeds were extracted with 80% hydro-methanol to evaluate its antiulcer effect, and part of the extract was fractionated into n-hexane, ethyl acetate, and aqueous solvents. The antiulcer activity of the crude extract and solvent fractions was tested using pylorus ligation and ethanol-induced ulcer models. Repeated dose studies were also performed on both models. In a pylorus ligation-induced ulcer model, single-dose studies showed that 200\u2009mg\/kg significantly reduced ulcer number, score (P\u2009&lt;\u20090.05), and index (P\u2009&lt;\u20090.01), providing 39.83% protection. The 400\u2009mg\/kg, significantly reduced ulcer number, and score (P\u2009&lt;\u20090.01), providing 55.80% protection. In a repeated-dose study, 100\u2009mg\/kg significantly reduced ulcer number and score (P\u2009&lt;\u20090.05). The 200\u2009mg\/kg dose showed stronger effects (P\u2009&lt;\u20090.01, for the above parameters, respectively). The highest dose (400\u2009mg\/kg) significantly reduced ulcer parameters (P\u2009&lt;\u20090.001) and also lowered gastric juice volume (P\u2009&lt;\u20090.01), acidity (P\u2009&lt;\u20090.05), and raised pH (P\u2009&lt;\u20090.01), providing 59.17% protection. In the ethanol-induced ulcer model, single-dose crude extract provided an ulcer index protection of 23.39%, 34.90%, and 54.04% at 100, 200, and 400\u2009mg\/kg, respectively. Repeated administration of the crude extract increased ulcer protection to 34.94%, 50.91%, and 65.72% at the same respective doses. All doses of the aqueous and the ethyl acetate fractions also showed antiulcer activity. This study confirmed that <jats:italic>Vicia faba<\/jats:italic> seeds crude extract and solvent fractions have significant antiulcer activity, providing scientific evidence supporting the traditional use of <jats:italic>V. faba<\/jats:italic> seeds as a remedy for gastric ulcers in Ethiopia.<\/jats:p>","DOI":"10.1371\/journal.pone.0334119","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:42:02Z","timestamp":1760031722000},"page":"e0334119","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of anti-ulcer activity of hydromethanol crude extract and solvent fractions of Vicia faba (Fabaceae) seeds in mice"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3247-080X","authenticated-orcid":true,"given":"Demis","family":"Getachew","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9867-5443","authenticated-orcid":true,"given":"Alemante Tafese","family":"Beyna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammedbrhan","family":"Abdelwuhab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assefa Belay","family":"Asrie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"issue":"2","key":"pone.0334119.ref001","first-page":"218","article-title":"Ijsrset151332","volume":"1","author":"K Suganya","year":"2015","journal-title":"IJSRSET"},{"issue":"1","key":"pone.0334119.ref002","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12876-022-02130-2","article-title":"The global, regional and national burden of peptic ulcer disease from 1990 to 2019: a population-based study","volume":"22","author":"X Xie","year":"2022","journal-title":"BMC Gastroenterol"},{"issue":"2","key":"pone.0334119.ref003","doi-asserted-by":"crossref","first-page":"124","DOI":"10.47583\/ijpsrr.2021.v68i02.019","article-title":"Herbal potentials for treatment of peptic ulcers: a review","volume":"68","author":"SB Wakodkar","year":"2021","journal-title":"Int J Pharm Sci Rev Res"},{"issue":"05","key":"pone.0334119.ref004","first-page":"7807","article-title":"A review on herbal potential for treatment of peptic ulcer","volume":"7807","author":"BS Shubham","year":"2023","journal-title":"Int Res J Modern Engineering Technologies"},{"issue":"2","key":"pone.0334119.ref005","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3390\/biom10020265","article-title":"Systematic Analysis of Monoterpenes: Advances and Challenges in the Treatment of Peptic Ulcer Diseases","volume":"10","author":"LL P\u00e9rico","year":"2020","journal-title":"Biomolecules"},{"issue":"1","key":"pone.0334119.ref006","first-page":"1","article-title":"Protective effect of snail secretion filtrate against ethanol-induced gastric ulcer in mice","volume":"11","author":"E Gugliandolo","year":"2021","journal-title":"Sci Rep [Internet"},{"issue":"4","key":"pone.0334119.ref007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.38164\/AJPER\/10.4.2021.1-17","article-title":"Peptic ulcer: a review on etiology, pathogenesis and treatment","volume":"10","author":"F Jaiswal","year":"2021","journal-title":"Asian J Pharmaceutical Education and Research"},{"issue":"12","key":"pone.0334119.ref008","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1038\/s41588-023-01569-7","article-title":"East Asian-specific and cross-ancestry genome-wide meta-analyses provide mechanistic insights into peptic ulcer disease","volume":"55","author":"Y He","year":"2023","journal-title":"Nat Genet"},{"key":"pone.0334119.ref009","unstructured":"Gupta H, Bhandari U. 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