{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:57:02Z","timestamp":1760576222648,"version":"build-2065373602"},"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004515","name":"Universiti Kebangsaan Malaysia","doi-asserted-by":"publisher","award":["FF-2025-112"],"award-info":[{"award-number":["FF-2025-112"]}],"id":[{"id":"10.13039\/501100004515","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>Artificial intelligence (AI) is transforming healthcare through tools like large language model chatbots. AI chatbots can simulate human conversation, provide personalized information, and interact with patients in real time. Their ease of use and conversational interface make them attractive for healthcare education, especially in resource-limited settings. We propose a prospective, single-masked, randomized controlled trial to evaluate whether an AI-based chatbot (ChatGPT) is non-inferior to standard counseling in terms of patients\u2019 adherence to pre-colonoscopy bowel preparation instructions and thus enhance the Boston Bowel Preparation Score (BBPS). Patients undergoing colonoscopy (n<jats:sub>total<\/jats:sub>\u2009=\u200996) will be randomized to ChatGPT 4.0 Large Language Model (LLM)-aided Colonoscopy Counseling (N<jats:sub>ChatGPT<\/jats:sub>\u2009=\u200948) or standard counseling (n<jats:sub>sc\u2009<\/jats:sub>=\u200948) arms at a 1:1 ratio using a central block randomization scheme of varying block sizes. In the first group, participants will interact with ChatGPT 4.0 for bowel preparation counseling before colonoscopy, whilst the second group will receive standard counseling from trained clinicians. Only the outcome assessors will be masked to the intervention allotment. The primary endpoint is the BBPS, assessed for non-inferiority. Secondary endpoints are patient anxiety (DASS-21) and patient satisfaction assessed using DASS-21 and PSQ-18 questionnaires, respectively and the findings will be reported descriptively with two-sided 95% confidence interval and any p-values will be considered exploratory without multiplicity adjustment. The primary endpoint data will be analyzed using the intention-to-treat (ITT) analysis and non-inferiority framework based on the analysis of covariance (ANCOVA) to control the confounders (age, gender (male as the risk factor), prior colonoscopy experience, colonoscopy indication, and baseline constipation score). The results will be compared with the findings based on the per-protocol (PP) analysis as part of the sensitivity analysis. The protocol adheres to SPIRIT 2025 and the SPIRIT-AI extension guidelines to ensure comprehensive reporting of this AI-based intervention. This trial has received ethics approval and the trial protocol has been registered with the clinicaltrials.gov registry (NCT06905782).<\/jats:p>","DOI":"10.1371\/journal.pone.0334349","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:36:09Z","timestamp":1760549769000},"page":"e0334349","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["A prospective single-masked, non-inferiority, parallel-group randomized controlled trial of the efficacy of a ChatGPT-based AI chatbot to improve Boston bowel preparation scores for colonoscopy preparation: A trial protocol"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6129-3786","authenticated-orcid":true,"given":"Nabil","family":"Mohammad 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doctor-patient fit and patient satisfaction in cancer care","volume":"53","author":"CMH Chan","year":"2012","journal-title":"Singapore Med J"},{"issue":"8","key":"pone.0334349.ref045","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1093\/qjmed\/hcp052","article-title":"Medication errors: what they are, how they happen, and how to avoid them","volume":"102","author":"JK Aronson","year":"2009","journal-title":"QJM"},{"key":"pone.0334349.ref046","unstructured":"Code of Federal Regulation, Title 21, Section 312.32 (21CFR312.32). (2020). https:\/\/www.accessdata.fda.gov\/scripts\/cdrh\/cfdocs\/cfcfr\/cfrsearch.cfm?fr=312.32. 27 May 2025."},{"issue":"3","key":"pone.0334349.ref047","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.gie.2009.10.027","article-title":"A lexicon for endoscopic adverse events: report of an ASGE workshop","volume":"71","author":"PB Cotton","year":"2010","journal-title":"Gastrointest Endosc"},{"issue":"4","key":"pone.0334349.ref048","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.gie.2011.07.025","article-title":"Complications of colonoscopy","volume":"74","author":"Committee ASGE Standards of Practice","year":"2011","journal-title":"Gastrointest Endosc"},{"key":"pone.0334349.ref049","author":"U.S. Department of Health and Human Services, National Institutes of Health, National Cancer Institute","year":"2017"},{"issue":"1","key":"pone.0334349.ref050","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41746-023-00786-y","article-title":"Improving bowel preparation for colonoscopy with a smartphone application driven by artificial intelligence","volume":"6","author":"Y Zhu","year":"2023","journal-title":"NPJ Digit Med"},{"issue":"24","key":"pone.0334349.ref051","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1001\/jama.2012.87802","article-title":"Reporting of noninferiority and equivalence randomized trials: extension of the CONSORT 2010 statement","volume":"308","author":"CONSORT Group","year":"2012","journal-title":"JAMA"},{"key":"pone.0334349.ref052","author":"International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use","year":"1998"},{"key":"pone.0334349.ref053","author":"U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Center for Biologics Evaluation and Research","year":"2017"},{"issue":"2","key":"pone.0334349.ref054","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10691898.2011.11889611","article-title":"Measuring skewness: a forgotten statistic?","volume":"19","author":"DP Doane","year":"2011","journal-title":"J Stat Educ"},{"issue":"3","key":"pone.0334349.ref055","article-title":"mice: Multivariate Imputation by Chained Equations inR","volume":"45","author":"van Buuren S","year":"2011","journal-title":"J Stat Soft"},{"issue":"1","key":"pone.0334349.ref056","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s12874-017-0442-1","article-title":"When and how should multiple imputation be used for handling missing data in randomised clinical trials - a practical guide with flowcharts","volume":"17","author":"JC Jakobsen","year":"2017","journal-title":"BMC Med Res Methodol"},{"key":"pone.0334349.ref057","volume-title":"Statistical analysis with missing data","author":"RJ Little","year":"2019","edition":"3"},{"issue":"4","key":"pone.0334349.ref058","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/sim.4067","article-title":"Multiple imputation using chained equations: Issues and guidance for practice","volume":"30","author":"IR White","year":"2011","journal-title":"Stat Med"},{"key":"pone.0334349.ref059","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1471-230X-11-86","article-title":"Appointment waiting times and education level influence the quality of bowel preparation in adult patients undergoing colonoscopy","volume":"11","author":"W-K Chan","year":"2011","journal-title":"BMC Gastroenterol"},{"issue":"12","key":"pone.0334349.ref060","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/S0895-4356(96)00236-3","article-title":"A simulation study of the number of events per variable in logistic regression analysis","volume":"49","author":"P Peduzzi","year":"1996","journal-title":"J Clin Epidemiol"},{"issue":"3","key":"pone.0334349.ref061","first-page":"411","article-title":"What you see may not be what you get: a brief, nontechnical introduction to overfitting in regression-type models","volume":"66","author":"MA Babyak","year":"2004","journal-title":"Psychosom Med"},{"issue":"22","key":"pone.0334349.ref062","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1056\/NEJMra1709701","article-title":"Multiplicity Considerations in Clinical Trials","volume":"378","author":"A Dmitrienko","year":"2018","journal-title":"N Engl J Med"},{"issue":"7321","key":"pone.0334349.ref063","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1136\/bmj.323.7321.1123","article-title":"Statistics notes: Analysing controlled trials with baseline and follow up measurements","volume":"323","author":"AJ Vickers","year":"2001","journal-title":"BMJ"},{"issue":"3","key":"pone.0334349.ref064","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jclinepi.2003.08.009","article-title":"Subgroup analyses in randomized trials: risks of subgroup-specific analyses; 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