{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:19:54Z","timestamp":1791656394024,"version":"4.3.4"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K27703"],"award-info":[{"award-number":["23K27703"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K16632"],"award-info":[{"award-number":["22K16632"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K23382"],"award-info":[{"award-number":["20K23382"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K02506"],"award-info":[{"award-number":["24K02506"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007263","name":"Astellas Foundation for Research on Metabolic Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007263","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>\n                    Post-cardiac arrest brain injury (PCABI) is the leading cause of death and disability following cardiac arrest (CA). Nicotinamide adenine dinucleotide (NAD\n                    <jats:sup>+<\/jats:sup>\n                    ) depletion after CA contributes to neuronal injury, while nicotinamide mononucleotide (NMN) replenishes NAD\n                    <jats:sup>+<\/jats:sup>\n                    and may provide neuroprotection via sirtuin activation. This study aimed to investigate the effects of systemic NMN administration on neurological function, survival, and sirtuin-3 (SIRT3) levels in the brain post-CA. In adult male mice (C57BL\/6NCrSlc, 10\u201315 weeks old), 10-min CA was induced by intravenous potassium chloride injection followed by cardiopulmonary resuscitation. NMN (60\u2009mg\/kg body weight) or normal saline (control) was randomly administered by intraperitoneal injection immediately after the return of spontaneous circulation (ROSC) and 24 and 48\u2009h post-CA. Brain NAD\n                    <jats:sup>+<\/jats:sup>\n                    and adenosine triphosphate (ATP) levels, neurological function score (NFS), survival, histological neuronal injury, and brain gene expression and protein levels were measured. Brain NAD\n                    <jats:sup>+<\/jats:sup>\n                    levels decreased at 2\u2009h post-ROSC and NMN significantly increased brain NAD\n                    <jats:sup>+<\/jats:sup>\n                    and ATP levels. At 48\u2009h post-CA, surviving mice in the NMN group exhibited significantly higher NFS (control: 8 [IQR: 4\u201312] vs. NMN: 12 [IQR: 9\u201312], p\u2009=\u20090.03) and less severe hippocampal neuronal injury compared with controls. Moreover, the NMN group showed significantly higher 7-day survival rate (control: 22.2% [4\/18] vs. NMN: 61.1% [11\/18], p\u2009=\u20090.03) and brain SIRT3 levels (control: 17.7\u2009\u00b1\u20093.6 vs. NMN: 34.5\u2009\u00b1\u20094.4 pg\/mg protein, p\u2009=\u20090.01). In conclusion, systemic NMN administration after ROSC attenuates PCABI. The increased brain ATP levels and SIRT3 upregulation may suggest the usefulness of NMN for improving mitochondrial function and contributing to neuroprotection. NAD\n                    <jats:sup>+<\/jats:sup>\n                    supplementation with NMN is a promising therapeutic approach against PCABI.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0334608","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T17:21:56Z","timestamp":1761067316000},"page":"e0334608","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Systemic nicotinamide mononucleotide administration to mitigate post-cardiac arrest brain injury in 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