{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:05Z","timestamp":1789776005570,"version":"4.0.1"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Zhejiang Medical and Health Science and Technology Project","award":["2024KY1459"],"award-info":[{"award-number":["2024KY1459"]}]},{"name":"Zhejiang TCM Science and Technology Project","award":["2023ZR128"],"award-info":[{"award-number":["2023ZR128"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:p>The current study investigated the therapeutic potential of Ph-triazole in silico and in vitro against pancreatic cancer. Common targets between Ph-triazole and pancreatic cancer, notably P53 protein, were identified using the venny 2.1.0 tool and imported into the String database to construct the protein-protein network. Box plot revealed that the most prominent hub gene TP53 is strongly up-regulated in pancreatic tumor tissues (N\u2009=\u2009179) compared to normal tissue samples (N\u2009=\u2009171), and stage plots confirmed that its upregulation is found during all four stages of the disease. Survival analysis of the pancreatic cancer patients revealed a strong correlation between TP53 gene overexpression and low overall survival and disease-free survival. Molecular docking showed that Ph-triazole exhibits a strong binding affinity for P53 protein. In vitro data also confirmed the anti-proliferative effect of Ph-triazole in pancreatic cancer cell models. Therefore, Ph-triazole can act as an anti-proliferative agent for pancreatic cancer and needs to be investigated further by in vivo studies.<\/jats:p>","DOI":"10.1371\/journal.pone.0334618","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T18:35:11Z","timestamp":1765305311000},"page":"e0334618","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["RETRACTED: Ph-triazole as a therapeutic agent for pancreatic cancer: Synthesis, in silico, and in vitro 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