{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T18:12:55Z","timestamp":1760465575134,"version":"build-2065373602"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["23HC2001"],"award-info":[{"award-number":["23HC2001"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Japan Agency for Medical Research","award":["JP24fk0210123"],"award-info":[{"award-number":["JP24fk0210123"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"\nBackground and aim<\/jats:title>\nThe incidence of hepatocellular carcinoma (HCC) is positively correlated with age, and the population of patients with HCC was also older at the time of clinical diagnosis. In the SURF trial, elderly people aged \u226580 years were excluded. We aimed to study the efficacy and safety of radiofrequency ablation (RFA) for patients aged over 80 years.<\/jats:p>\n<\/jats:sec>\n\nMethods<\/jats:title>\nPatients who underwent RFA at our institution for the initial treatment of HCC tumors with largest diameters of \u22643\u2009cm, and \u22643 HCC nodules from January 2011 to December 2023. Treatment outcomes and prognoses were examined in the elderly group (\u226580 years) and in the nonelderly group (<80 years). The Cox proportional hazards model was used to determine the factors associated with treatment outcomes and prognoses.<\/jats:p>\n<\/jats:sec>\n\nResults<\/jats:title>\nOf the 518 eligible patients, 136 patients were aged \u226580 years. The median overall survival (OS) values were 80 (95%CI; 60\u201396) and 123 (95%CI; 101\u2013nucleotide analogs (NA)) months (p\u2009=\u20090.021) in the elderly and nonelderly groups, respectively. For liver disease-related deaths, the median OS values were 97 (95% CI; 80\u2013NA) and NR (95% CI; NA\u2013NA) months (p\u2009=\u20090.62) in the elderly and nonelderly groups, respectively. In the multivariate analysis, factors associated with OS were ALBI grade 2 or 3 (HR, 1.67, 95%CI; 1.07\u20132.60), DCP\u2009\u2265\u200940 mAU\/ml (HR, 2.08, 95%CI; 1.42\u20133.04), persistent hepatitis C virus (HCV) infection (HR, 5.46, 95%CI; 3.08\u20139.69), and nonviral liver disease (HR, 4.19, 95%CI; 2.32\u20137.57).<\/jats:p>\nThe median recurrence-free survival values were 16 (95%CI; 14\u201322) and 26 (95%CI; 19\u201330) months, respectively (p\u2009=\u20090.023). HCC recurrence was significantly associated with the male sex (HR, 1.50, 95%CI; 1.17\u20131.93), elderly group (HR, 1.37, 95%CI; 1.10\u20131.95), ALBI grade 2 or 3 (HR, 1.39, 95%CI; 1.07\u20131.80), DCP\u2009\u2265\u200940 mAU\/ml (HR, 1.41, 95%CI; 1.10\u20131.81), and persistent HCV infection (HR, 1.67, 95%CI; 1.30\u20132.15). The factors associated with liver disease-related death were ALBI grade 2 or 3 (HR, 2.17, 95% CI; 1.26\u20133.75), DCP\u2009\u2265\u200940 mAU\/ml (HR, 2.33, 95% CI; 1.47\u20133.69), and persistent HCV infection (HR, 2.22, 95% CI; 1.39\u20133.56).<\/jats:p>\n<\/jats:sec>\n\nConclusions<\/jats:title>\nIn RFA for tumors with diameters of \u22643\u2009cm and \u22643 HCC nodules, age over \u226580 years was not a significant factor associated with OS or liver disease-related death. The results support that RFA would be a promising treatment option for patients with HCC patients aged \u226580 years.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0334712","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T17:34:34Z","timestamp":1760463274000},"page":"e0334712","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical outcome of radiofrequency ablation in patients with hepatocellular carcinoma aged 80 years and 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