{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:12:32Z","timestamp":1791317552261,"version":"4.3.1"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"\n Purpose<\/jats:title>\n \n To analyze phytochemical composition, antioxidant potential, antimicrobial activity and \u03b1-glucosidase, cholinesterase and Monoamine oxidase inhibitory potential of\n Oxalis corniculata<\/jats:italic>\n extract.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Phytochemicals of the 70% ethanolic extract of\n O. corniculata<\/jats:italic>\n were quantitatively determined by standard spectrophotometric method. The anti-oxidative and antibacterial potential were investigated by DPPH scavenging test and by well-diffusion method respectively. The p-NPG technique was applied to evaluate \u03b1-glucosidase inhibition potential. Moreover, cholinesterase and Monoamine oxidase -A & -B activities were examined by Elman\u2019s method and fluorometric kynuramine deamination test respectively.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Phytochemical study revealed the presence of tannin quantity in range 586\u2009\u00b1\u20090.05 \u00b5g\/mg followed by flavonoid; 154.83\u2009\u00b1\u20090.04 \u00b5g\/mg and phenolic contents; 135.29\u2009\u00b1\u20090.01 \u00b5g\/mg. DPPH radical scavenging of the extract indicates good IC\n 50<\/jats:sub>\n value 40.74 \u00b5g\/ml according to the standard ascorbic acid; 25.79 \u00b5g\/ml. The bacterial inhibition revealed that the extract were high inhibitory against\n E. coli, H. influenza<\/jats:italic>\n and\n k. pneumonia<\/jats:italic>\n while showing no inhibition against\n Acetobactor aceti<\/jats:italic>\n . Similarly, Acetylcholinesterase and Butyrylcholinesterase inhibition result revealed that\n O. corniculata<\/jats:italic>\n have effective anti-cholinesterase potential with the IC\n 50<\/jats:sub>\n value of Acetylcholinesterase; 34.54 \u00b5g\/ml and Butyrylcholinesterase; 8.91 \u00b5g\/ml. Moreover,\n O. corniculata<\/jats:italic>\n has good potential against MAO-B inhibition with an IC\n 50<\/jats:sub>\n value; 60.68 \u00b5g\/ml, while showing IC\n 50<\/jats:sub>\n value; 274.23 \u00b5g\/ml against MAO-A. Furthermore, the inhibitory potential against \u03b1- glucosidase of the extract shows significant IC\n 50<\/jats:sub>\n value (40.59 \u00b5g\/ml).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n O. corniculata<\/jats:italic>\n exhibits potential as a valuable reservoir of natural bioactive compounds endowed with a wide array of health-promoting properties.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1371\/journal.pone.0335026","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T17:25:17Z","timestamp":1778779517000},"page":"e0335026","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["In-vitro studies of phytochemical, Antioxidant, Antibacterial and Enzymatic inhibition of Oxalis corniculata whole plant from South Waziristan Tribal District Pakistan"],"prefix":"10.1371","volume":"21","author":[{"given":"Inayat","family":"Ullah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor","family":"Shad Bibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul","family":"Sadiq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3540-9053","authenticated-orcid":true,"given":"Bakhtyar","family":"Niazy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atiq Mohammad","family":"Hesam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"issue":"5","key":"pone.0335026.ref001","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1007\/s11101-019-09629-9","article-title":"Importance of ethnopharmacological studies in drug discovery: role of medicinal plants","volume":"19","author":"I S\u00fcntar","year":"2019","journal-title":"Phytochem Rev"},{"issue":"5","key":"pone.0335026.ref002","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/ptr.6024","article-title":"Antiviral potential of medicinal plants against HIV, HSV, influenza, hepatitis, and coxsackievirus: a systematic review","volume":"32","author":"M Akram","year":"2018","journal-title":"Phytother Res"},{"key":"pone.0335026.ref003","first-page":"789","article-title":"Ayurveda and natural products drug discovery","author":"B Patwardhan","year":"2004","journal-title":"Current Science"},{"issue":"1","key":"pone.0335026.ref004","first-page":"136","article-title":"Sacred plants from ancient to modern era: traditional worshipping towards plants conservation","volume":"3","author":"D Pandey","year":"2016","journal-title":"Tropical Plant Research"},{"issue":"3","key":"pone.0335026.ref005","first-page":"375","article-title":"Phytochemical screening and in vitro antimicrobial activity of Bougainvillea spectabilis flower extracts","volume":"4","author":"K Sudipta","year":"2012","journal-title":"International Journal of Phytomedicine"},{"issue":"4","key":"pone.0335026.ref006","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3390\/molecules21040369","article-title":"Plectranthus amboinicus (Lour.) 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