{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:49:59Z","timestamp":1792457399177,"version":"4.5.0"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Eosinophilic esophagitis (EoE) has known associations with allergic conditions. Previous studies have reported an increased frequency of EoE in patients with IgE-mediated food allergies (FA), however, statistical validation in large inpatient cohorts remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods and Findings<\/jats:title>\n                    <jats:p>A retrospective analysis was performed using the National Inpatient Sample (NIS) database from 2016 to 2022. International Classification of Diseases, 10th Revision (ICD-10) codes were used to identify patients with a primary or secondary diagnosis of EoE and FA. Multivariable logistic regression was performed to assess the relationship between EoE and FA. Multivariable regression analysis showed a strong association between EoE and milk (aOR: 7.52, p\u2009&lt;\u20090.001), egg (aOR: 4.77, p\u2009&lt;\u20090.001), peanut (aOR: 3.94, p\u2009&lt;\u20090.001), and seafood allergy (aOR: 2.57, p\u2009&lt;\u20090.001). Among patients with a FA studied, Black (aOR: 0.47, p\u2009=\u20090.001) and Hispanic (aOR: 0.45, p\u2009=\u20090.001) patients had lower odds of EoE compared to White patients. Patients aged 45\u201364 (aOR: 0.18, p\u2009=\u20090.001) and over 65 (aOR: 0.06, p\u2009=\u20090.001) years with FA had decreased odds of EoE compared to patients under 18. Patients in the highest household zip code income quartile (\u2265 $86,000) had the greatest odds of EoE (aOR: 1.79, p\u2009=\u20090.001) when compared to the lowest quartile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study supports a strong association between EoE and milk, egg, peanut, and seafood allergies, and the findings across demographics show notable disparities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0335078","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T17:26:09Z","timestamp":1761240369000},"page":"e0335078","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Eosinophilic esophagitis and its association with food allergies: A United States national analysis 2016 to 2022"],"prefix":"10.1371","volume":"20","author":[{"given":"Misha","family":"Shah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4146-7016","authenticated-orcid":true,"given":"Abhin","family":"Sapkota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishaan","family":"Aravindaksha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gedion Yilma","family":"Amdetsion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kriti","family":"Katwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anas","family":"Almoghrabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"pone.0335078.ref001","doi-asserted-by":"crossref","first-page":"679","DOI":"10.2147\/JAA.S238565","article-title":"The Role of Food Allergy in Eosinophilic Esophagitis","volume":"13","author":"JM Wilson","year":"2020","journal-title":"J Asthma Allergy"},{"issue":"9","key":"pone.0335078.ref002","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11894-015-0458-9","article-title":"Do We Know What Causes Eosinophilic Esophagitis? 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