{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:45:47Z","timestamp":1790999147903,"version":"4.1.0"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare long-term outcomes of XEN\u00ae45 (XEN) and PRESERFLO\u2122 MicroShunt (PRESERFLO) implants in the surgical management of glaucoma over a 3-year follow-up period, focusing on intraocular pressure (IOP) reduction, need of medication, surgical success, and postoperative complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective, matched case control study was conducted, including 42 eyes with preceded implantation of a XEN or PRESERFLO. Patients were statistically matched using SPSS algorithms for glaucoma diagnosis, previous surgery, and demographics. Standardized success criteria defined surgical outcomes: complete success (IOP\u2009\u2264\u200915 mmHg or \u2264 18 mmHg without medications) and qualified success (IOP\u2009\u2264\u200915 mmHg with &lt; 3 medications). Postoperative care and needling or revision interventions were recorded. Statistical analyzes included Wilcoxon, Mann-Whitney U, and t-tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both devices significantly reduced IOP and glaucoma medication over 3 years. XEN reduced IOP from 22.1\u2009\u00b1\u20098.6 mmHg to 13.5\u2009\u00b1\u20093.8 mmHg, while PRESERFLO reduced IOP from 22.1\u2009\u00b1\u20096.6 mmHg to 12.6\u2009\u00b1\u20094.0 mmHg (p\u2009&gt;\u20090.05 for between-groups, 3 years postoperative). Medication use decreased from 2.4\u2009\u00b1\u20091.0 to 0.9\u2009\u00b1\u20091.4 for XEN and 3.1\u2009\u00b1\u20091.1 to 1.1\u2009\u00b1\u20090.9 for PRESERFLO (p\u2009&gt;\u20090.05 for between-groups). Surgical success rates were similar after 3 years. PRESERFLO showed fewer postoperative revisions (28.6% vs. 42.9% for XEN; p\u2009&gt;\u20090.05). Early hypotony occurred more frequently with XEN (17 vs. 7 cases; p\u2009=\u20090.029).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both XEN and PRESERFLO effectively reduce IOP and the need for glaucoma medication, with comparable surgical success rates after 3 years. PRESERFLO demonstrated a lower revision rate and reduced frequency of early postoperative hypotony. These findings support both implants as viable options for minimally invasive glaucoma surgery, with low risk profiles.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0335080","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T17:31:54Z","timestamp":1761931914000},"page":"e0335080","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Matching of XEN\u00ae45 and PRESERFLO\u2122 MicroShunt cases: Outcomes of a 3-year follow-up"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4384-1066","authenticated-orcid":true,"given":"Cemre","family":"Altas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7732-9507","authenticated-orcid":true,"given":"Marcus","family":"Walckling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Brockmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Stelzle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anselm","family":"J\u00fcnemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Fuchsluger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"issue":"5","key":"pone.0335080.ref001","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1136\/bjophthalmol-2016-EGSguideline.002","article-title":"European Glaucoma Society Terminology and Guidelines for Glaucoma, 4th Edition - Chapter 2: Classification and terminologySupported by the EGS Foundation: Part 1: Foreword; 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