{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T18:49:08Z","timestamp":1763059748087,"version":"3.45.0"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Joint Funds for the innovation of science and Technology, Fujian province","award":["2021Y9190"],"award-info":[{"award-number":["2021Y9190"]}]},{"name":"Science and Technology Project of Fujian Province","award":["2021Y0052"],"award-info":[{"award-number":["2021Y0052"]}]},{"name":"Science and Technology Project of Fujian Province","award":["2022Y0056"],"award-info":[{"award-number":["2022Y0056"]}]},{"name":"Startup Fund for scientific research, Fujian Medical University","award":["2024QH1173"],"award-info":[{"award-number":["2024QH1173"]}]},{"name":"Fujian Provincial Clinical Research Center for Cancer Radiotherapy and Immunotherapy","award":["2020Y2012"],"award-info":[{"award-number":["2020Y2012"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"\n Objective<\/jats:title>\n To compare dosimetric differences among graphical-based manual planning (MA), simulated annealing inverse optimization (IPSA), and hybrid inverse optimization (HIPO) for cervical cancer in both intra-cavitary brachytherapy (ICBT) and interstitial brachytherapy combined with ICBT (IC\/ISBT) settings, providing evidence for clinical optimization method selection.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This study consisted of 60 cervical cancer patients undergoing CT-guided three-dimensional brachytherapy, including 30 ICBT patients and 30 IC\/ISBT patients. Plans were generated using MA, IPSA, and HIPO. The dosimetric parameters for the high-risk clinical target volume (HRCTV) including D\n 100%<\/jats:sub>\n , V\n 150%<\/jats:sub>\n , V\n 200%<\/jats:sub>\n , conformity index (CI), homogeneity index (HI) were compared. Meanwhile, the dosimetric parameters D\n 1cc<\/jats:sub>\n , D\n 2cc<\/jats:sub>\n for the bladder, rectum, sigmoid, and total treatment time were evaluated.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Compared with MA, both IPSA and HIPO delivered lower doses to organs at risk (OARs). The total treatment time was significantly shorter for HIPO compared to IPSA and MA (P\u2009<\u20090.05). In ICBT patients, the D\n 1cc<\/jats:sub>\n and D\n 2cc<\/jats:sub>\n of OARs were lower for IPSA compared to HIPO (P\u2009>\u20090.05), while the CI was significantly better for HIPO (P\u2009<\u20090.05). Nevertheless, in IC\/ISBT patients, D\n 2cc<\/jats:sub>\n of rectum for HIPO was significantly lower compared to IPSA (P\u2009<\u20090.05), with better CI.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Inverse optimization effectively reduces doses to OARs while maintaining target coverage. HIPO appears to be the preferred choice for IC\/ISBT, due to shortened treatment time, superior CI and rectal protection compared with IPSA.<\/jats:p>\n <\/jats:sec>","DOI":"10.1371\/journal.pone.0335405","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T18:42:21Z","timestamp":1763059341000},"page":"e0335405","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dosimetric divergence in ICBT vs. IC\/ISBT configurations: Comparative analysis of three optimization algorithms for cervical cancer brachytherapy"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4496-507X","authenticated-orcid":true,"given":"Jihong","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiabiao","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiqiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuchun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guohua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Penggang","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"issue":"15","key":"pone.0335405.ref001","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1002\/cncr.35334","article-title":"Top advances of the year: Cervical cancer","volume":"130","author":"LR Duska","year":"2024","journal-title":"Cancer"},{"key":"pone.0335405.ref002","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.canrad.2021.11.009","article-title":"Radiotherapy of cervical cancer","volume":"26","author":"C Chargari","year":"2022","journal-title":"Cancer Radiother"},{"issue":"3","key":"pone.0335405.ref003","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1136\/ijgc-2021-003056","article-title":"Image-guided brachytherapy in cervical cancer including fractionation","volume":"32","author":"AE Sturdza","year":"2022","journal-title":"Int J Gynecol Cancer"},{"issue":"3","key":"pone.0335405.ref004","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.radonc.2018.03.003","article-title":"The European Society of Gynaecological Oncology\/European Society for Radiotherapy and Oncology\/European Society of Pathology guidelines for the management of patients with cervical cancer","volume":"127","author":"D Cibula","year":"2018","journal-title":"Radiother Oncol"},{"key":"pone.0335405.ref005","doi-asserted-by":"crossref","unstructured":"Akbarov K, Guliyev E, Aliyeva N, Huseynov RRJB. 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