{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:27:19Z","timestamp":1777390039985,"version":"3.51.4"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Natural Science Funds for Distinguished Young Scholars of Anhui Province","award":["82371080"],"award-info":[{"award-number":["82371080"]}]},{"name":"Natural Science Funds for Distinguished Young Scholar of Anhui Province","award":["2308085J29"],"award-info":[{"award-number":["2308085J29"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inflammation significantly contributes to cataract formation; Pan-immune inflammation value (PIV) is an emerging marker that may reflect systemic inflammation. This study aimed to explore the connection between PIV and cataract formation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 8,235 participants from the National Health and Nutrition Examination Survey (NHANES) between 2005 and 2008. PIV was log-transformed, and weighted logistic regression, restricted cubic splines (RCS), subgroup, and sensitivity analyses were performed to evaluate associations. The receiver operating characteristic (ROC) curves were used to assess predictive performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cataract prevalence was 6.6%. Higher ln-PIV was positively associated with cataract prevalence [OR=1.35, 95%CI: 1.08\u20131.69, P\u2009=\u20090.015]. The association was linear, consistent across subgroups, and robust in sensitivity analyses. The ROC analysis indicated that PIV had better predictive ability for cataract than other inflammatory indices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found that higher PIV levels were positively associated with cataract prevalence, which highlights the value of inflammatory markers in assessing cataract development and provides new ideas for the clinical detection of cataracts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0335713","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T17:37:06Z","timestamp":1761932226000},"page":"e0335713","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pan-immune inflammation value: A novel biomarker for 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