{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:18:11Z","timestamp":1791994691521,"version":"4.4.0"},"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ege University Scientific Research Projects Coordination","award":["TS-GAP-2024-31975"],"award-info":[{"award-number":["TS-GAP-2024-31975"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Supernumerary teeth are a common developmental anomaly in pediatric patients, potentially leading to complications such as impaction, crowding, and delayed eruption. Accurate and early detection is critical to prevent these sequelae and guide appropriate intervention strategies. This study aims to evaluate the diagnostic accuracy and clinical applicability of a convolutional neural networks-based deep learning model (YOLOv8) for the automated localization and binary classification of supernumerary teeth on pediatric panoramic radiographs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted on 2000 pediatric panoramic radiographs following ethical approval. Three calibrated pediatric dentists independently examined the dataset and annotated a representative subset of 140 radiographs (71 positive, 69 negative), achieving substantial inter-rater agreement (Cohen\u2019s \u03ba\u2009=\u20090.92). Performance was assessed in two stages: (1) segmentation of supernumerary teeth and (2) binary classification of radiographs. An independent validation set of 20 radiographs was used for secondary evaluation. Evaluation metrics included precision, recall, F1-score, and McNemar\u2019s test to compare model predictions with expert labelling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean age of the patients was 9.6\u2009\u00b1\u20092.3 years; 52% were male, 48% were female. The segmentation model yielded 100% precision, 38% recall, and an F1-score of 55%, indicating strong localization when detections were made but limited sensitivity. The classification model achieved 100% accuracy, precision, recall, and F1-score on both internal and external datasets. McNemar\u2019s test revealed no statistically significant discrepancy between the model and expert decisions (p\u2009&gt;\u20090.05). The segmentation model demonstrated high precision in localizing supernumerary teeth; however, recall performance was more modest, indicating occasional under-detection. Due to the limited validation sample size, these findings should be interpreted with caution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The YOLOv8-based pipeline demonstrated robust diagnostic accuracy in classifying panoramic radiographs for supernumerary teeth and promising but preliminary results in lesion-level segmentation. These findings highlight the potential utility of advanced deep learning systems in augmenting early diagnosis and streamlining pediatric dental radiology workflows.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0335845","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T18:32:23Z","timestamp":1762367543000},"page":"e0335845","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Deep learning-based automated detection of supernumerary teeth in pediatric panoramic 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