{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:48:04Z","timestamp":1790747284900,"version":"4.1.0"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS One"],"abstract":"\n Background<\/jats:title>\n Central sensitization is an important factor associated with impaired health-related quality of life in patients with musculoskeletal disorders and community-dwelling older adults. However, health-related quality-of-life domains strongly associated with central sensitization in the general population remain unclear. This study aimed to examine the association between the Central Sensitization Inventory Part A scores and health-related quality of life using community health checkup data.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A total of 419 middle-aged and older adults (mean age, 64.4\u2009\u00b1\u200911.2 years; 59.4% female) were included. Participants completed a questionnaire survey on pain, including visual analogue scales (VASs) for lower-back and knee pain, and the Central Sensitization Inventory Part A. Additionally, participants completed the Short-Form 36-Item Health Survey, and three component-summary scores and eight subscales were calculated. Additionally, participants completed the 5-level EuroQol 5 dimensions, and health-state utility values were calculated. The correlation between the Central Sensitization Inventory Part A scores and these health-related quality-of-life measures was investigated.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Central Sensitization Inventory Part A score \u226540 was observed in 2.6% participants. Significant moderate negative correlations were observed between the Central Sensitization Inventory Part A scores and EuroQol 5 dimensions health-state utility values (\n \n r<\/jats:italic>\n \u2009\n <\/jats:italic>\n = \u22120.631,\n \n P<\/jats:italic>\n \u2009\n <\/jats:italic>\n <\u20090.001), Short-Form 36 mental-component summary (\n \n r<\/jats:italic>\n \u2009\n <\/jats:italic>\n = \u22120.550,\n \n P<\/jats:italic>\n \u2009\n <\/jats:italic>\n <\u20090.001), body pain (\n \n r<\/jats:italic>\n \u2009\n <\/jats:italic>\n = \u22120.556,\n \n P<\/jats:italic>\n \u2009\n <\/jats:italic>\n <\u20090.001), general health (\n \n r<\/jats:italic>\n \u2009\n <\/jats:italic>\n = \u22120.556,\n \n P<\/jats:italic>\n \u2009\n <\/jats:italic>\n <\u20090.001), vitality (\n \n r<\/jats:italic>\n \u2009\n <\/jats:italic>\n = \u22120.610,\n \n P<\/jats:italic>\n \u2009\n <\/jats:italic>\n <\u20090.001), and mental health (\n \n r<\/jats:italic>\n \u2009\n <\/jats:italic>\n = \u22120.556,\n \n P<\/jats:italic>\n \u2009\n <\/jats:italic>\n <\u20090.001). Similar results were obtained for participants with Central Sensitization Inventory Part A scores <30.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n In community-dwelling middle-aged and older adults, Central Sensitization Inventory Part A scores were negatively correlated with health-related quality-of-life scores, even in participants with Central Sensitization Inventory Part A scores <30.<\/jats:p>\n <\/jats:sec>","DOI":"10.1371\/journal.pone.0335923","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:37:01Z","timestamp":1761845821000},"page":"e0335923","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between the central sensitization inventory score and health-related quality of life in community-dwelling middle-aged and older adults"],"prefix":"10.1371","volume":"20","author":[{"given":"Naoki","family":"Segi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0039-9678","authenticated-orcid":true,"given":"Hiroaki","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryotaro","family":"Oishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadayuki","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ouchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ippei","family":"Yamauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Nagatani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisuke","family":"Seki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Takegami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Ishizuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiharu","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Imagama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"key":"pone.0335923.ref001","doi-asserted-by":"crossref","DOI":"10.1016\/j.pain.2010.09.030","article-title":"Central 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