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Emerging evidence suggest it may play a role in the association between social isolation \u2013 loneliness and health outcomes. People living with HIV (PLWH) exhibit chronic inflammation even with viral suppression, likely due to ongoing immune activation. However, few studies have explored inflammatory biomarker in PLWH experiencing loneliness or social isolation. This study aimed to assess this association in PLWH aged 50 or older.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0335949","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T18:35:59Z","timestamp":1765996559000},"page":"e0335949","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lack of association between loneliness, social isolation and inflammation in people living with HIV aged \u226550 years: Results from the sub-study \u201cNo One Alone-Gesida 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